Spray Freeze Drying in a Fluidized Bed at Normal and Low Pressure

Leuenberger, Hans; Plitzko, Matthias; Puchkov, Maxim

doi:10.1080/07373930600684932

Cited by 60 publications

(21 citation statements)

References 9 publications

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“…In pharmaceutical industry, freeze-drying is widely used to preserve proteins and polypeptides, which are physically and/or chemically unstable in aqueous solutions (1). The improved stability of freeze-dried proteins provides many benefits such as storage stability at ambient temperature, extended shelf life, convenient handling…”

Section: Introductionmentioning

confidence: 99%

An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria

et al. 2007

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Section: Introductionmentioning

confidence: 99%

An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria

et al. 2007

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“…[131,132] When spray freeze drying was carried out at lower pressures, it result into shorter drying times and produced more uniform protein particles. [133] It was also found that the spray freeze drying had an excellent capability to produce dry and stable thermosensitive substances. [133] Rajkumar et al (2007) reported that the quality of tomato slices dried by vacuum-assisted solar drying was of superior quality in terms of color retention and rehydration ratio due to their more porous structure.…”

Section: Microwave-assisted Dryingmentioning

confidence: 98%

“…[133] It was also found that the spray freeze drying had an excellent capability to produce dry and stable thermosensitive substances. [133] Rajkumar et al (2007) reported that the quality of tomato slices dried by vacuum-assisted solar drying was of superior quality in terms of color retention and rehydration ratio due to their more porous structure. [134] Studies have shown that vacuum-assisted microwave drying combines the advantages of evaporation of moisture at relatively low temperature, faster removal of moisture at low absolute pressure (due to vacuum), and rapid volumetric heating capability of microwave and produces better-quality products.…”

Section: Microwave-assisted Dryingmentioning

confidence: 98%

Effect of Water on the Quality of Dehydrated Products: A Review of Novel Characterization Methods and Hybrid Drying Technologies

2014

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The effect of water on the quality of dried products is reviewed in light of recent applications of novel characterization methods (nuclear magnetic resonance (NMR), X-ray spectroscopy, and Raman spectroscopy) in quantifying the state and mobility of water in dried products. The mechanical configuration and ability of a number of hybrid drying technologies that use novel heating sources (microwave, infrared, radiofrequency) and/or sub-atmospheric pressure in producing better-quality products are reviewed in considerable detail. The drying kinetics models, especially those related to the quality loss, are also reviewed. It appears that more and more drying research is now focused on the development of novel hybrid technologies to produce better-quality products and for energy savings. The novel characterization technologies listed above are capable of quantifying the dynamic mobility and state of water in dried food products; this information can be used to design more efficient drying processes.

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“…They found that the drying time is reduced significantly compared to normal freeze-drying. More recently, Leuenberger et al [35] reported spray freeze-drying of pharmaceuticals using cooled and dehumidified air obtained by dry ice. Rogers et al [47] investigated milk powder characteristics in laboratory-scale spray freeze-dryer using liquid nitrogen as the cryogen.…”

Section: The Developments In Spray Drying Process Used In Dairy Industrymentioning

confidence: 99%

An overview of the recent advances in spray-drying

Mujumdar

Huang

Chen

2010

Dairy Sci. Technol.

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-A global overview is presented of recent developments in spray drying. Recent advances in computational fluid dynamics modeling have provided new insights into the flow processes occurring within the spray chamber. This is important since detailed experimental measurements within an operating spray dryer are almost impossible due to the hostile environment of hightemperature two-phase flow, which may be unsteady, and the high cost that would have to incur. Some recent predictive studies on predicted effects of innovative chamber geometry, reduced pressure operation, operation in low dew-point air and superheated steam are presented. Also, a comparison is made between steady and unsteady state computations to highlight the critical issues. Predicted results on a horizontal spray chamber configuration are also presented. Finally, a brief survey is made on the recent literature on spray freeze-drying as well as multi-stage drying processes.computational fluid dynamics / modeling / spray drying / CFDRésumé -Récentes avancées dans la conception et l'optimisation des installations de séchage par pulvérisation : une vue d'ensemble. Un inventaire des récents développements dans le domaine du séchage par pulvérisation est dressé. Les dernières avancées de la dynamique des fluides numérique ont permis d'obtenir de nouvelles représentations des processus d'écoulement ayant lieu à l'intérieur de la chambre de séchage. Ces modélisations sont très importantes car des mesures expérimentales détaillées à l'intérieur d'une installation de séchage en fonctionnement sont pratiquement impossibles à réaliser, en raison des conditions hostiles liées au flux à température élevée de deux phases, pouvant être irrégulier, et aux coûts qui seraient engendrés. Des études prédictives récentes sur les effets d'une géométrie innovante de la chambre, de conditions de pression réduite, d'air à bas point de rosée et de vapeur surchauffée, sont notamment présentées. Article published by EDP Sciences Une comparaison des calculs réalisés dans des conditions stables ou instables est également réalisée afin de mettre en lumière les points critiques. Les résultats de la prédiction pour une configuration de chambre horizontale sont présentés. Enfin, les dernières publications sur le couplage séchage par pulvérisation-lyophilisation et les procédés de séchage multi-étage sont présentées rapidement.dynamique des fluides / modélisation / séchage par pulvérisation / CFD

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Spray Freeze Drying in a Fluidized Bed at Normal and Low Pressure

Cited by 60 publications

References 9 publications

An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria

An Interactive Tool for the Optimization of Freeze-Drying Cycles Based on Quality Criteria

Effect of Water on the Quality of Dehydrated Products: A Review of Novel Characterization Methods and Hybrid Drying Technologies

An overview of the recent advances in spray-drying

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