Spread of Community‐Acquired Methicillin‐Resistant <i>Staphylococcus aureus</i> (MRSA) in Hospitals in Taipei, Taiwan in 2005, and Comparison of Its Drug Resistance with Previous Hospital‐Acquired MRSA

Takano, Tomomi; Saito, Kohei; Teng, Lee‐Jene; Yamamoto, Tatsuo

doi:10.1111/j.1348-0421.2007.tb03949.x

Cited by 23 publications

(17 citation statements)

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“…Further, MRSA isolates of the group 1b complexes CCs121 and 59 have been recovered from cases of disease in east Asia. For example, ST59 is common amongst PVL positive CA-MRSA isolates in Taiwan, and is thought to have clonally spread in this country [38], [39], where it is particularly associated with pediatric infection [40]. Despite these caveats, our analysis indicates that a full understanding of virulence potential in human pathogens requires both phylogenetic and biogeographic contexts.…”

Section: Discussionmentioning

confidence: 89%

Biogeography and Virulence of Staphylococcus aureus

et al. 2009

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Background Staphylococcus aureus is commonly carried asymptomatically in the human anterior nares and occasionally enters the bloodstream to cause invasive disease. Much of the global diversity of S. aureus remains uncharacterised, and is not clear how disease propensity varies between strains, and between host populations.MethodologyWe compared 147 isolates recovered from five kindergartens in Chengdu, China, with 51 isolates contemporaneously recovered from cases of pediatric infection from the main hospital serving this community. The samples were characterised by MLST, the presence/absence of PVL, and antibiotic resistance profiling.Principal FindingsGenotype frequencies within individual kindergartens differ, but the sample recovered from cases of disease shows a general enrichment of certain MLST genotypes and PVL positive isolates. Genotypes under-represented in the disease sample tend to correspond to a single sequence cluster, and this cluster is more common in China than in other parts of the world.Conclusions/SignificanceVirulence propensity likely reflects a synergy between variation in the core genome (MLST) and accessory genome (PVL). By combining evidence form biogeography and virulence we demonstrate the existence of a “native” clade in West China which has lowered virulence, possibility due to acquired host immunity.

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Section: Discussionmentioning

confidence: 89%

Biogeography and Virulence of Staphylococcus aureus

et al. 2009

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“…Additional novel SCC mec elements have been described [6]; [14]–[17] which indicate an ongoing evolution of antibiotic resistance in S. aureus . As β-lactam antibiotics are the first-line compounds for treatment of staphylococcal infections, this development may significantly limit therapeutic options.…”

Section: Introductionmentioning

confidence: 99%

A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus

Coombs²,

et al. 2011

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In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly global challenge. In addition to the long-known healthcare-associated clones, novel strains have also emerged outside of the hospital settings, in the community as well as in livestock. The emergence and spread of virulent clones expressing Panton-Valentine leukocidin (PVL) is an additional cause for concern. In order to provide an overview of pandemic, epidemic and sporadic strains, more than 3,000 clinical and veterinary isolates of MRSA mainly from Germany, the United Kingdom, Ireland, France, Malta, Abu Dhabi, Hong Kong, Australia, Trinidad & Tobago as well as some reference strains from the United States have been genotyped by DNA microarray analysis. This technique allowed the assignment of the MRSA isolates to 34 distinct lineages which can be clearly defined based on non-mobile genes. The results were in accordance with data from multilocus sequence typing. More than 100 different strains were distinguished based on affiliation to these lineages, SCCmec type and the presence or absence of PVL. These strains are described here mainly with regard to clinically relevant antimicrobial resistance- and virulence-associated markers, but also in relation to epidemiology and geographic distribution. The findings of the study show a high level of biodiversity among MRSA, especially among strains harbouring SCCmec IV and V elements. The data also indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements.

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“…1 But cases of CA-MRSA spreading in hospitals have been reported in some countries. 2,3 This fact points to the possibility of increased morbidity and mortality caused by MRSA infections in hospitalized patients and the necessity for enhancing surveillance for MRSA carriers. Although the CDC has been recommending the performance of active surveillance culture (ASC) for the prevention of MRSA infection and for infection control since their guideline was issued in 2006, many variant types of MRSA with various characteristics have been found since then.…”

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confidence: 98%

Comparative evaluation of a rapid MRSA detection assay based on multiplex real-time PCR versus MRSA screening cultures containing egg yolk

Sumitani

Kobayashi

2009

Journal of Infection and Chemotherapy

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Spread of Community‐Acquired Methicillin‐Resistant Staphylococcus aureus (MRSA) in Hospitals in Taipei, Taiwan in 2005, and Comparison of Its Drug Resistance with Previous Hospital‐Acquired MRSA

Abstract: Panton-Valentine leucocidin (PVL)-positive methicillin-resistant Staphylococcus aureus (PVL

Cited by 23 publications

References 33 publications

Biogeography and Virulence of Staphylococcus aureus

Biogeography and Virulence of Staphylococcus aureus

A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus

Comparative evaluation of a rapid MRSA detection assay based on multiplex real-time PCR versus MRSA screening cultures containing egg yolk

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