Spread of different rhinovirus B genotypes in hospitalized children in Spain

Cuevas, María Teresa; Molinero, Mar; Pozo, Francisco; Calvo, Cristina; García-García, Maria Luz; Reyes, Noelia; Ledesma, Juan; Casas, Inmaculada

doi:10.1111/irv.12061

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…This agrees with epidemiological data observing that RV circulates more efficiently in the rainy season of tropical countries in Latin America [56]. Contradicting these findings, Lopes et al, observed an increased RV circulation in the dry season in Brazil, with infections peaking in November and December [57]. A study in Cambodia also showed that RV was predominant in the winter months which correspond to the dry season in this country [54].…”

Section: Rhinovirus Seasonalitysupporting

confidence: 80%

Understanding Rhinovirus Circulation and Impact on Illness

Esneau

Duff

Bartlett

2022

Viruses

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Rhinoviruses (RVs) have been reported as one of the main viral causes for severe respiratory illnesses that may require hospitalization, competing with the burden of other respiratory viruses such as influenza and RSV in terms of severity, economic cost, and resource utilization. With three species and 169 subtypes, RV presents the greatest diversity within the Enterovirus genus, and despite the efforts of the research community to identify clinically relevant subtypes to target therapeutic strategies, the role of species and subtype in the clinical outcomes of RV infection remains unclear. This review aims to collect and organize data relevant to RV illness in order to find patterns and links with species and/or subtype, with a specific focus on species and subtype diversity in clinical studies typing of respiratory samples.

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Section: Rhinovirus Seasonalitysupporting

confidence: 80%

Understanding Rhinovirus Circulation and Impact on Illness

Esneau

Duff

Bartlett

2022

Viruses

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“…This result is consistent with other similar studies [4]. On the other hand, some previous studies also report the significant role of high humidity on increased RV circulation [43,44], contradicting studies that found increased RV circulation in periods with low humidity [18,45]. Understanding the effects of environmental factors on RV circulation is becoming even more important in the current era of climate change for the implementation of adequate public health measures to contain the burden of RV infections in the community.…”

Section: Discussionsupporting

confidence: 88%

Seasonality and Genotype Diversity of Human Rhinoviruses during an Eight-Year Period in Slovenia

Berginc,

Sočan,

Prosenc Trilar

et al. 2024

Microorganisms

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Due to the high socioeconomic burden of rhinoviruses, the development of prevention and treatment strategies is of high importance. Understanding the epidemiological and clinical features of rhinoviruses is essential in order to address these issues. Our study aimed to define the seasonality and molecular epidemiology of rhinoviruses in Slovenia. Over a period of eight years, a total of 20,425 patients from sentinel primary healthcare settings and sentinel hospitals were examined for a panel of respiratory viruses in the national programme for the surveillance of influenza-like illnesses and acute respiratory infections. The patients were from all age groups and had respiratory infections of various severity. Infection with a rhinovirus was confirmed using an RT-rPCR in 1834 patients, and 1480 rhinoviruses were genotyped. The molecular analysis was linked to demographical and meteorological data. We confirmed the year-round circulation of rhinoviruses with clear seasonal cycles, resulting in two seasonal waves with peaks in spring and autumn. High levels of genotype variability and co-circulation were confirmed between and within seasons and were analysed in terms of patient age, the patient source reflecting disease severity, and meteorological factors. Our study provides missing scientific information on the genotype diversity of rhinoviruses in Slovenia. As most previous investigations focused on exclusive segments of the population, such as children or hospitalised patients, and for shorter study periods, our study, with its design, size and length, contributes complementary aspects and new evidence-based knowledge to the regional and global understanding of rhinovirus seasonality and molecular epidemiology.

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“…Indeed, our previous report suggested that the genomes of HRV-C detected in Japanese subjects with various ARIs showed .30 % divergence based on sequences in the VP4/VP2 coding region, and these strains could be classified into many genotypes by phylogenetic analysis (Arakawa et al, 2012). Furthermore, studies of the VP4/VP2 coding region have allowed detailed phylogenetic analysis of the genotypes of HRV-A to -C (Arakawa et al, 2012;Cuevas et al, 2012;McIntyre et al, 2010;Simmonds et al, 2010). It appears, then, that this region could be useful for the detailed genetic analysis of HRV-C, although the evolution of the region is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of the VP4/VP2 coding region in human rhinovirus species C in patients with acute respiratory infection in Japan

Kiyota¹,

Kushibuchi

Kobayashi

et al. 2013

Journal of Medical Microbiology

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Detailed genetic analysis was carried out of the VP4/VP2 coding region in human rhinovirus species C (HRV-C) strains detected in patients with acute respiratory infection in Japan. Phylogenetic trees were constructed by the neighbour-joining (NJ) and maximum-likelihood (ML) methods. The NJ phylogenetic tree assigned 11 genotypes to the present strains, whilst the ML tree showed that the strains diversified sometime in the early 1870s. Moreover, the pairwise distance among the present strains was relatively long, and the rate of molecular evolution of the coding region was rapid (3.07¾10 "3 substitutions per site per year). The results suggest that the present HRV-C strains have a wide genetic divergence and a unique evolutionary timescale.

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Spread of different rhinovirus B genotypes in hospitalized children in Spain

Cited by 7 publications

References 18 publications

Understanding Rhinovirus Circulation and Impact on Illness

Understanding Rhinovirus Circulation and Impact on Illness

Seasonality and Genotype Diversity of Human Rhinoviruses during an Eight-Year Period in Slovenia

Genetic analysis of the VP4/VP2 coding region in human rhinovirus species C in patients with acute respiratory infection in Japan

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