Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state

Valiatti, Tiago Barcelos; Carvalho, Tatiane Silva de; Santos, Fernanda dos; Nodari, Carolina Silva; Cayô, Rodrigo; Silva, Juliana Thalita Paulino da; Silva, Cicileia Correia da; Ferreira, Jacqueline Andrade; Moura, Lorena Brandhuber de; Santos, Levy Assis dos; Gales, Ana Cristina

doi:10.1007/s42770-022-00706-4

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Although the increase in resistance in A. baumannii was not as high as that in E. coli and K. pneumoniae , this bacterium already has intrinsic resistance to ertapenem and a high rate of resistance to meropenem and imipenem, as demonstrated by studies in Rondônia where the resistance to carbapenem was 76.2% 11 , 4.91% higher than what we found in our study; IC1 was the most frequent clonal group, followed by IC5 and IC4 12 . Furthermore, the greatest ARG plasticity was detected in A. baumannii , which presented with bla KPC -like or bla NDM -like together with bla OXA23 -like and bla OXA58 -like or even bla OXA23 -like together with bla OXA143 -like.…”

Section: Discussioncontrasting

confidence: 55%

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

dos Santos,

Cayô,

Valiatti

et al. 2024

Sci Rep

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Brazil is recognized for its biodiversity and the genetic variability of its organisms. This genetic variability becomes even more valuable when it is properly documented and accessible. Understanding bacterial diversity through molecular characterization is necessary as it can improve patient treatment, reduce the length of hospital stays and the selection of resistant bacteria, and generate data for health and epidemiological surveillance. In this sense, in this study, we aimed to understand the biodiversity and molecular epidemiology of carbapenem-resistant bacteria in clinical samples recovered in the state of Rondônia, located in the Southwest Amazon region. Retrospective data from the Central Public Health Laboratories (LACEN/RO) between 2018 and 2021 were analysed using the Laboratory Environment Manager Platform (GAL). Seventy-two species with carbapenem resistance profiles were identified, of which 25 species carried at least one gene encoding carbapenemases of classes A (blaKPC-like), B (blaNDM-like, blaSPM-like or blaVIM-like) and D (blaOXA-23-like, blaOXA-24-like, blaOXA-48-like, blaOXA-58-like or blaOXA-143-like), among which we will highlight Klebsiella pneumoniae, Pseudomonas aeruginosa, Acinetobacter baumannii, Serratia marcescens, and Providencia spp. With these results, we hope to contribute to the field by providing epidemiological molecular data for state surveillance on bacterial resistance and assisting in public policy decision-making.

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Section: Discussioncontrasting

confidence: 55%

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

dos Santos,

Cayô,

Valiatti

et al. 2024

Sci Rep

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“…So far, several ICs have been more frequently reported, and among them, the IC2 (represented by the ST2 determined by the MLST Pasteur scheme) is the most globally disseminated and prevalent carbapenem-resistant A. baumannii (CRAB) lineage that has been involved with difficult-to-treat outbreaks around the world [5][6][7][8]. In Brazil, A. baumannii of IC1, IC4, IC5 and to a lesser extent, IC7, have been the most prevalent international clones circulating all over the country [9][10][11][12][13][14]. Moreover, the IC6 international clone (ST78 PAS /ST944 OXF ) was recently described in the Brazilian Amazon region [15].…”

Section: Introductionmentioning

confidence: 99%

Outbreak of a carbapenem-resistant XDRAcinetobacter baumanniibelonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022

da Fonseca,

Morgado,

Santos Freitas

et al. 2023

Preprint

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Carbapenem-resistant Acinetobacter baumannii (CRAB) is a leading cause of nosocomial infections worldwide, and the occurrence of extensively drug-resistant (XDR) lineages among them is increasing. Most of A. baumannii pandemic lineages, known as International clones, are represented by MDR/XDR CRAB strains. The IC2 is considered one of the most successful and widespread pandemic clones, however, it is rare in South America, where IC1, IC4 and IC5 are prevalent. In Brazil, besides sporadic reports, an IC2 outbreak was reported only once in Sao Paulo city during the COVID-19 pandemics. This study characterized an outbreak caused by IC2 strains (n=16) in a hospital in Rio de Janeiro in 2022. MLST (MLST Pasteur scheme) analysis revealed that all strains recovered from nosocomial infections belonged to ST2 and corresponded to CRAB presenting the XDR phenotype. In general, this broad resistance spectrum was explained by the presence of several antibiotic resistance genes (ARGs) (armA, blaTEM, blaOXA-23, blaOXA-66, and aacA4-catB8-aadA1-qacEdelta1/sul1 carried in class 1 integron). Interestingly, the strains characterized here presented a broader resistance spectrum compared to those of the unique other and contemporary IC2 outbreak in Brazil, although they shared most of the ARGs. This study stressed the possibility of the successful establishment of IC2 in Brazilian clinical settings during and after the COVID-19 pandemics in response to a series of events, such as the overuse of antibiotics, during that period.

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Persistence of a carbapenem-resistant Acinetobacter baumannii (CRAB) International Clone II (ST2/IC2) sub-lineage involved with outbreaks in two Brazilian clinical settings

Fonseca,

Morgado,

Freitas

et al. 2023

Journal of Infection and Public Health

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Spread of multidrug-resistant Acinetobacter baumannii isolates belonging to IC1 and IC5 major clones in Rondônia state

Cited by 3 publications

References 27 publications

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

Biodiversity of carbapenem-resistant bacteria in clinical samples from the Southwest Amazon region (Rondônia/Brazil)

Outbreak of a carbapenem-resistant XDRAcinetobacter baumanniibelonging to the International Clone II (IC2) in a clinical setting in Brazil, 2022

Persistence of a carbapenem-resistant Acinetobacter baumannii (CRAB) International Clone II (ST2/IC2) sub-lineage involved with outbreaks in two Brazilian clinical settings

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