Spread of the community-acquired methicillin-resistant Staphylococcus aureus USA300 clone among family members in Japan

Super-sticky familial infections caused by Panton–Valentine leukocidin-positive ST22 community-acquired methicillin-resistant Staphylococcus aureus in Japan

“…In our previous studies, colonization of Japanese households by USA300 (PVL-and ACME-positive ST8 CA-MRSA, which most probably originated from the United States) persisted for about a year, and caused severe invasive infection in a child [15,16]; however, after the patient's 2 and 3 in B) were used as reference strains treatment, such USA300 persistence spontaneously disappeared from the households [16]. No MRSA persistence among households occurred in a pediatric SSTI case caused by PVL-positive ST59 CA-MRSA (which might have originated from Taiwan) [30], in a fatal pediatric pneumonia case caused by PVL-positive ST30 CA-MRSA [18], or in an invasive infection of a high school student (an athlete) caused by PVL-positive ST30 CA-MRSA [31].…”

“…In a previous study, we demonstrated that PVL-and ACME-positive USA300, which most probably originated from the United States, persisted among related family members for a year in Japan, and caused severe invasive infection in a child [15,16]. In this study, we demonstrate that PVL-positive novel ST22 CA-MRSA, which most probably originated from India, persisted among related family members for more than 2 years (actually, for 3 years) with frequent deep abscesses and possessed extremely high ability for biofilm formation.…”

A New Local Variant (ST764) of the Globally Disseminated ST5 Lineage of Hospital-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) Carrying the Virulence Determinants of Community-Associated MRSA

“…The control strains used in this study include N315 (ST5 [31]), Mu50 (ST5 [31]), I6 (ST5 [32]), I8 (ST5 [32]), I10 (ST5 [this study]), BK2464 (ST5 [4]), USA300-0114 (ST8 [33]), NN36 (ST8 [34]), NN47 (ST8 [35]), 549 (ST8 [36]), PM1 (ST59 [37]), and COL (ST250 [5,6]). …”

The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics

“…McDougal and L.L. McDonald) and three Japanese isolates: NN36 from a 3-month-old Indian girl with abscesses [16]; NN47 from an 11-month-old Japanese girl with cellulitis and sepsis followed by osteomyelitis [17]; and 549 from an inpatient and medical staff with abscesses and cellulitis [18]. PVL-positive CA-MRSA included ST22 strain NN48 from familial infection cases [19], ST30 strains NN1 and NN12 from bullous impetigo and bloodstream infection [11], ST59 strains PM1 (from Taiwan [20]) and OS7 from cellulitis [21], and ST80 strains HT20030345 (from the Netherlands) and HT200 30442 (France) [22]; strains HT20030345 and HT200 30442 were kindly provided by Jerome Etienne.…”