Spreading Waves of a Reduced Diffusion Coefficient of Water in Normal and Ischemic Rat Brain

Hasegawa, Yasuhiro; Latour, Lawrence L.; Formato, James E.; Sotak, Christopher H.; Fisher, Marc

doi:10.1038/jcbfm.1995.23

Cited by 111 publications

(70 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6, was not determined in this study. They may have resulted from transient changes in CBF or by transient depolarizations caused by spreading depression (39,40). Spreading depression could effectively increase the CBF threshold for ADC reduction above that associated with energy failure.…”

Section: Discussionmentioning

confidence: 99%

“…CBF rates were estimated with a method that corrects for the "wash-out" volume of blood in the arterial and venous catheters (25). The percent of ischemic hemisphere with CBF rates less than 15,20,25,30,35,40, and 50 m1/100 g/min (CBF 15 , CBF 20 , CBF 25 , CBF 30 , CBF 35 , CBF 40 , and CBF 50 ) was determined for three sections from within the 2-mm thick slice of the MR images. Reported results are the mean of the three measurements.…”

Section: Cbf Measurementmentioning

confidence: 99%

See 1 more Smart Citation

Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats

Mancuso

Karibe

Rooney

et al. 1995

Magnetic Resonance in Med

View full text Add to dashboard Cite

To determine the relationship between reductions in the apparent diffusion coefficient of water (ADC) and in cerebral blood flow (CBF) during focal ischemia, we used diffusion-weighted magnetic resonance (D-MR) imaging and autoradiographic CBF analysis to examine rats subjected to 30 or 90 min of permanent middle cerebral artery (MCA) occlusion. In the 30-min occlusion group (n = l0), the area with substantially reduced ADC (15% or more below the contralateral level [ADCJ 15 ]) corresponded best to the area with CBF below 25 ml/lOO g/min and was significantly smaller than the area with CBF below 50 m1/100 g/min (CBF 50 ), a level associated with reduced protein synthesis and delayed necrosis (40 ± 13% versus 74 ± 8% of the ischemic hemisphere; P < 0.OOOl). In the 90-min occlusion group (n = 6), the ADC 15 area corresponded best to the CBF 30 to CBF 35 area and was again significantly smaller than the CBF 50 area (54 ± 13% versus 73 ± 20%, P < 0.05). Thus, the area of substantially reduced ADC at 30 and 90 min represents only 53% and 74%, respectively, of the tissue at risk for infarction. These findings indicate a potential limitation in using early D-MR imaging to predict stroke outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Cbf Measurementmentioning

confidence: 99%

Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats

Mancuso

Karibe

Rooney

et al. 1995

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…A first attempt to discover the phenomenon by repetitive imaging of the apparent diffusion coefficient failed (Back et al, 2000), presumably because the successful demonstration of propagating PIDs by repetitive magnetic resonance (MR) diffusion mapping in experimental stroke in rats (Gyngell et al, 1994;Hasegawa et al, 1995) could not be easily reproduced in humans. The time period covered by apparent diffusion coefficient imaging amounted for example to only 15 minutes per patient, providing little opportunity to capture a depolarization wave.…”

Section: Malignant Hemispheric Strokementioning

confidence: 99%

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

Lauritzen

Dreier

Fabricius

et al. 2010

J Cereb Blood Flow Metab

682

582

View full text Add to dashboard Cite

Cortical spreading depression (CSD) and depolarization waves are associated with dramatic failure of brain ion homeostasis, efflux of excitatory amino acids from nerve cells, increased energy metabolism and changes in cerebral blood flow (CBF). There is strong clinical and experimental evidence to suggest that CSD is involved in the mechanism of migraine, stroke, subarachnoid hemorrhage and traumatic brain injury. The implications of these findings are widespread and suggest that intrinsic brain mechanisms have the potential to worsen the outcome of cerebrovascular episodes or brain trauma. The consequences of these intrinsic mechanisms are intimately linked to the composition of the brain extracellular microenvironment and to the level of brain perfusion and in consequence brain energy supply. This paper summarizes the evidence provided by novel invasive techniques, which implicates CSD as a pathophysiological mechanism for this group of acute neurological disorders. The findings have implications for monitoring and treatment of patients with acute brain disorders in the intensive care unit. Drawing on the large body of experimental findings from animal studies of CSD obtained during decades we suggest treatment strategies, which may be used to prevent or attenuate secondary neuronal damage in acutely injured human brain cortex caused by depolarization waves.

show abstract

“…[6,7] Son zamanlarda geçici DAG anormalliklerinin yayılan depresyon, eksitotoksik hasar ve hayvanlarda uzamış nöbetlerde de görülebildiği bildirilmektedir. [6,[8][9][10] Nöbet sırasında sitotoksik veya vazojenik ödemin ön planda olmasına bağlı olarak DAG ve ADC bulguları değişebilir. [11,12] Epilepsi hastalarında DAG değişli-likleri iskemik inme ile benzerdir.…”

Section: Olgu Sunumuunclassified

Acute Ischemic Cerebrovascular Disease Clinical and Imaging Findings in an Epileptic Case

Uslu¹,

Bebek²,

Çoban³

et al. 2014

Epilepsi

View full text Add to dashboard Cite

ÖzetDifüzyon ağırlıklı manyetik rezonans görüntülemede (DAG) hiperintensite ve 'apparent diffusion coefficient' (ADC) haritalamasında hipointensite sitotoksik ödemi gösteren bir bulgudur. Bu değişiklikler akut iskemik serebrovasküler olay için tipiktir. Epileptik nöbetlere eşlik eden beyin tomografisi (BT) ve manyetik rezonans görüntülemelerinde (MRG) geçici görüntüleme bulgularının varlığı bilinmektedir. Hayvanlarda parsiyel status epileptikus (PSE) esnasında yapılmış MRG çalışmalarında epileptik alanda sitotoksik ödemi düşündüren DAG ve ADC anormallikleri ve benzer bulguların insanlarda da oluştuğu gösterilmiştir. Epilepsi ile birlikteliği bilinen ve geçici MRG değişiklikleri yapan diğer durumlar migren ve geçici iskemik ataktır. Yeni başlangıçlı migrenöz baş ağrıları, tekrarlayan duysal yakınmalarının ardından gelişen güçsüzlük ve geçici MRG bulguları izlenen 44 yaşında bir hastanın ışığında geçici MRG bulguları saptanabilen nörolojik hastalıklar tartışılmıştır.Anahtar sözcükler: Diffuzyon ağırlıklı magnetik resonans görüntüleme; epilepsi; geçici MR bulguları; iskemik inme. SummaryHyperintensity at diffusion weighted magnetic resonance imaging (DWI) and hipointensity at 'apparent diffusion coefficient' (ADC) mapping are indicators of cytotoxic edema. These changes are typical for acute ischemic cerebrovascular accidents. During epileptic seizures, transient imaging findigs can be seen in the cranial computed tomography and magnetic resonance imaging. MRI studies during partial status epilepticus in animals show DWI and ADC anomalies which can be related to cytotoxic oedema. Same findings can also be seen in humans. Migraine and transient ischemic attacks can cause transient changes in the MRI which may also accompany epileptic seizures. We discuss here a 44 years old patient who had sensorial complaints and weakness after new onset migraine -like headache accompanied by transient MRI findings.

show abstract

Spreading Waves of a Reduced Diffusion Coefficient of Water in Normal and Ischemic Rat Brain

Cited by 111 publications

References 46 publications

Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats

Correlation of early reduction in the apparent diffusion coefficient of water with blood flow reduction during middle cerebral artery occlusion in rats

Clinical Relevance of Cortical Spreading Depression in Neurological Disorders: Migraine, Malignant Stroke, Subarachnoid and Intracranial Hemorrhage, and Traumatic Brain Injury

Acute Ischemic Cerebrovascular Disease Clinical and Imaging Findings in an Epileptic Case

Contact Info

Product

Resources

About