SPRi analysis of molecular interactions of mApoE-functionalized liposomes as drug delivery systems for brain diseases

Picciolini, Silvia; Rodà, Francesca; Gualerzi, Alice; Mangolini, Valentina; Forleo, Luana; Mangolini, Aurora; Sesana, Silvia; Antoniou, Antonia; Re, Francesca; Seneci, Pierfausto; Bedoni, Marzia

doi:10.1039/d3an01507f

Analyst

2023

DOI: 10.1039/d3an01507f

|View full text |Cite

SPRi analysis of molecular interactions of mApoE-functionalized liposomes as drug delivery systems for brain diseases

Silvia Picciolini,

Francesca Rodà,

Alice Gualerzi

et al.

Abstract: The SPRi analysis was optimized to study the interactions between mApoE-functionalized liposomes and receptors present in the brain and on monocytes and lymphocytes, demonstrating to be an excellent technique for characterization of liposomes.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Evaluation of Nanomaterials as Effective Carriers Targeted to Traverse Blood–Brain Barrier for Theragnostics of Neurodegenerative Diseases: An Overview

Vengadesan,

Arumugam,

Manikandan

et al. 2024

BioNanoSci.

View full text Add to dashboard Cite

Evaluation of Nanomaterials as Effective Carriers Targeted to Traverse Blood–Brain Barrier for Theragnostics of Neurodegenerative Diseases: An Overview

Vengadesan,

Arumugam,

Manikandan

et al. 2024

BioNanoSci.

View full text Add to dashboard Cite

Current Non-Metal Nanoparticle-Based Therapeutic Approaches for Glioblastoma Treatment

Gawel,

Betkowska,

Gajda

et al. 2024

Biomedicines

View full text Add to dashboard Cite

The increase in the variety of nano-based tools offers new possibilities to approach the therapy of poorly treatable tumors, which includes glioblastoma multiforme (GBM; a primary brain tumor). The available nanocomplexes exhibit great potential as vehicles for the targeted delivery of anti-GBM compounds, including chemotherapeutics, nucleic acids, and inhibitors. The main advantages of nanoparticles (NPs) include improved drug stability, increased penetration of the blood–brain barrier, and better precision of tumor targeting. Importantly, alongside their drug-delivery ability, NPs may also present theranostic properties, including applications for targeted imaging or photothermal therapy of malignant brain cells. The available NPs can be classified into two categories according to their core, which can be metal or non-metal based. Among non-metal NPs, the most studied in regard to GBM treatment are exosomes, liposomes, cubosomes, polymeric NPs, micelles, dendrimers, nanogels, carbon nanotubes, and silica- and selenium-based NPs. They are characterized by satisfactory stability and biocompatibility, limited toxicity, and high accumulation in the targeted tumor tissue. Moreover, they can be easily functionalized for the improved delivery of their cargo to GBM cells. Therefore, the non-metal NPs discussed here, offer a promising approach to improving the treatment outcomes of aggressive GBM tumors.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

SPRi analysis of molecular interactions of mApoE-functionalized liposomes as drug delivery systems for brain diseases

Abstract: The SPRi analysis was optimized to study the interactions between mApoE-functionalized liposomes and receptors present in the brain and on monocytes and lymphocytes, demonstrating to be an excellent technique for characterization of liposomes.

Cited by 2 publications

References 38 publications

Evaluation of Nanomaterials as Effective Carriers Targeted to Traverse Blood–Brain Barrier for Theragnostics of Neurodegenerative Diseases: An Overview

Evaluation of Nanomaterials as Effective Carriers Targeted to Traverse Blood–Brain Barrier for Theragnostics of Neurodegenerative Diseases: An Overview

Current Non-Metal Nanoparticle-Based Therapeutic Approaches for Glioblastoma Treatment

Contact Info

Product

Resources

About