Modern engineering systems tend to be more complicated than ever before, facilitated by novel design concepts and advancements in new technologies such as sensors, materials, and structural (or functional) integrity. Reliability and safety investigations are to find the most feasible, economical, and easy-to-follow solutions for failure prevention and performance improvement with the assistance of operation state modeling and analysis, failure and reliability analysis with environmental issues, maintenance strategy planning, and so forth.The demand for state-of-the-art solutions in these areas is surging, providing feasible approaches to guide both performance and profitability enhancement. In response, this special issue showcases original research that addresses newly emerged reliability and safety challenges in modern engineering systems. It contributes innovative ideas to academia and presents the latest and most intriguing applications in engineering practice.This special issue publishes novel, and the most representative reliability and safety achievements presented at the 2023