Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes

Rosa, Thiago Santos; Neves, Rodrigo Vanerson Passos; Deus, Lysleine Alves; Sousa, Caio Victor; Aguiar, Samuel da Silva; Souza, Michel Kendy; Rosa, Érica Carine Campos Caldas; Andrade, Rosângela Vieira de; Korhonen, Mikko; Simões, Herbert Gustavo

doi:10.1016/j.niox.2020.05.004

Cited by 30 publications

(48 citation statements)

References 32 publications

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“…19 Master athletes have better redox balance and inflammatory status compared with middle age-matched controls. 23 Thus, physical activity may be a strategy to prevent clinical severity in elderly persons with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Physical Activity Decreases the Prevalence of COVID-19-associated Hospitalization: Brazil EXTRA Study

Souza

Motta‐Santos

Soares

et al. 2020

Preprint

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Objectives: We compared physical activity levels before the outbreak and quarantine measures with COVID-19-associated hospitalization prevalence in surviving patients infected with SARS-CoV-2. Additionally, we investigated the association of physical activity levels with symptoms of the disease, length of hospital stay, and mechanical ventilation. Methods: Between June 2020 and August 2020, we invited Brazilian survivors and fully recovered patients infected with SARS-CoV-2 to respond to an online questionnaire. We shared the electronic link to the questionnaire on the internet. In this cross-sectional study, we collected data about clinical outcomes (symptoms, medications, hospitalization, and length of hospital stay) and cofactors, such as age, sex, ethnicity, preexisting diseases, socioeconomic and educational, and physical activity levels using the International Physical Activity Questionnaire (IPAQ short version). Results: Out of 938 patients, 91 (9.7%) were hospitalized due to COVID-19. In a univariate analysis, sex, age, and BMI were all associated with hospitalizations due to COVID-19. Men had a higher prevalence of hospitalization (66.6%, P=0.013). Patients older than 65 years, obese, and with preexisting disease had a higher prevalence of COVID-19-related hospitalizations. In a multivariate regression model, performance of at least 150 min/wk (moderate) and/or 75 min/wk (vigorous) physical activity was associated with a lower prevalence of hospitalizations after adjustment for age, sex, BMI, and preexisting diseases (PR=0.657; P=0.046). Conclusions: Sufficient physical activity levels are associated with a lower prevalence of COVID-19-related hospitalizations. Performing at least 150 minutes a week of moderate-intensity, or 75 minutes a week of vigorous-intensity physical activity reduces this prevalence by 34.3%.

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Section: Discussionmentioning

confidence: 99%

Physical Activity Decreases the Prevalence of COVID-19-associated Hospitalization: Brazil EXTRA Study

Souza

Motta‐Santos

Soares

et al. 2020

Preprint

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“…However, increased RONS production in skeletal muscle is implicated in muscle damage and impaired muscle performance [23]. Regarding the training status, it has recently been shown [24] that sprinter and endurance master athletes have better redox balance and inflammatory status, compared to the age-matched control, but worse than the untrained adults. Regarding the exercise mode, sprinters presented a better antioxidant capacity than both the controls and endurance runners, whereas the nitric-oxide profile (as a marker of endothelial function) was better for endurance runners and lower for the controls.…”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 99%

Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

Higgins

Izadi

Kaviani

2020

IJERPH

126

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Antioxidant supplementation, including vitamin E and C supplementation, has recently received recognition among athletes as a possible method for enhancing athletic performance. Increased oxidative stress during exercise results in the production of free radicals, which leads to muscle damage, fatigue, and impaired performance. Despite their negative effects on performance, free radicals may act as signaling molecules enhancing protection against greater physical stress. Current evidence suggests that antioxidant supplementation may impair these adaptations. Apart from athletes training at altitude and those looking for an immediate, short-term performance enhancement, supplementation with vitamin E does not appear to be beneficial. Moreover, the effectiveness of vitamin E and C alone and/or combined on muscle mass and strength have been inconsistent. Given that antioxidant supplements (e.g., vitamin E and C) tend to block anabolic signaling pathways, and thus, impair adaptations to resistance training, special caution should be taken with these supplements. It is recommended that athletes consume a diet rich in fruits and vegetables, which provides vitamins, minerals phytochemicals, and other bioactive compounds to meet the recommended intakes of vitamin E and C.

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“…This report also illustrates that the search for biomarkers can open up new directions for understanding disease pathology and therapeutic development without being immediately translatable to the clinic. Interestingly, FGF23 has been identified as a biomarker of aging, frailty, and age-related diseases including neurodegeneration (dementia) and sarcopenia [45][46][47][48] . Our findings identify ALS as another neurodegenerative disease linked to FGF23, and it will be of great interest in future studies to determine its contribution to disease progression.…”

Section: Discussionmentioning

confidence: 99%

FGF23, A Novel Muscle Biomarker Detected in The Early Stages of ALS

Kazamel

Benatar

et al. 2021

Preprint

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive muscle weakness. Skeletal muscle is a prime source for biomarker discovery since it is one of the earliest sites to manifest disease pathology. From a prior RNA sequencing project, we identified FGF23 as a potential muscle biomarker in ALS. Here, we validate this finding with a large collection of ALS muscle samples and found a 13-fold increase over normal controls. FGF23 was also increased in the SOD1G93A mouse, beginning at a very early stage and well before the onset of clinical symptoms. FGF23 levels progressively increased through end-stage in the mouse. Immunohistochemistry of ALS muscle showed prominent FGF23 immunoreactivity in the endomysial connective tissue and along the muscle membrane. ELISA of plasma samples from the SOD1G93A mouse showed an increase in FGF23 at end-stage whereas no increase was detected in a large cohort of ALS patients. In conclusion, FGF23 is a novel muscle biomarker in ALS and joins a molecular signature that emerges in very early preclinical stages. The early appearance of FGF23 and its progressive increase with disease advancement offers a new direction for exploring the molecular basis or response to the underlying pathology of ALS.

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Sprint and endurance training in relation to redox balance, inflammatory status and biomarkers of aging in master athletes

Cited by 30 publications

References 32 publications

Physical Activity Decreases the Prevalence of COVID-19-associated Hospitalization: Brazil EXTRA Study

Physical Activity Decreases the Prevalence of COVID-19-associated Hospitalization: Brazil EXTRA Study

Antioxidants and Exercise Performance: With a Focus on Vitamin E and C Supplementation

FGF23, A Novel Muscle Biomarker Detected in The Early Stages of ALS

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