Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation

Lochovska, Katerina; Peterková, Renata; Pavlíková, Zuzana; Hovořáková, Mária

doi:10.1186/s12861-015-0070-0

Cited by 15 publications

(19 citation statements)

References 42 publications

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“…In the lower jaw, we observed a similar tendency, with R2 and M1 signaling centers occasionally coexisting only in DUHi, but never in FVB ( Supplementary Figures 6 and 7). In both strains, the lower R2 signaling center was ultimately part of the mature M1 signaling center known as the pEK (Supplementary Figure 2 R and P), as shown for other mouse strains (Lochovska et al, 2015).…”

Section: The Premolar Signaling Center Persists Longer In Duhi Than Isupporting

confidence: 53%

“…The primordium known as "R2" has been linked to the last premolar (Lesot et al, 1998;Peterkova et al, 1996;Peterková et al, 2002;Prochazka et al, 2010;Viriot et al, 2002). In the lower jaw, the R2 signaling center interacts in a complex manner with the signaling center of the first molar (Lochovska et al, 2015;Prochazka et al, 2010;Sadier et al, 2019). In CD1 mice, R2 and early M1 signaling center transiently co-exist before fusing to form the mature M1 signaling center known as the pEK (Lochovska et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…In the lower jaw, the R2 signaling center interacts in a complex manner with the signaling center of the first molar (Lochovska et al, 2015;Prochazka et al, 2010;Sadier et al, 2019). In CD1 mice, R2 and early M1 signaling center transiently co-exist before fusing to form the mature M1 signaling center known as the pEK (Lochovska et al, 2015). From an early cap stage, the R2 primordium becomes thus integrated into the lower first molar.…”

Section: Introductionmentioning

confidence: 99%

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Developmental variability drives mouse molar evolution along an evolutionary line of least resistance

Hayden

Lochovska

Sémon

et al. 2019

Preprint

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Developmental systems may preferentially produce certain types of variation and, thereby, bias phenotypic evolution. This is a central issue in evolutionary developmental biology, albeit somewhat understudied. Here we focus on the shape of the first upper molar which shows a clear, repeated tendency for anterior elongation at different scales from within mouse populations to between species of the Mus genus. In contrast, the lower molar displays more evolutionary stability. We compared upper and lower molar development of mouse strains representative of this fine variation (DUHi: elongated molars and FVB: short molars). Using a novel quantitative approach to examine small-scale developmental variation, we identified temporal, spatial and functional differences in tooth signaling centers between the two strains, likely due to different tuning of the activation-inhibition mechanisms ruling signaling center patterning. Based on the spatio-temporal dynamics of signaling centers and their lineage tracing, we show an intrinsic difference in the fate of signaling centers between lower and upper jaw of both strains. This can explain why variations in activation-inhibition parameters between strains are turned into anterior elongation in the upper molar only. Finally, although the "elongated" DUHi strain was inbred, first molar elongation was variable in adults, and we found high levels of intra-strain developmental variation in upper molar development. This is consistent with the inherent developmental instability of the upper molar system enabling the morphological variability of the tooth phenotype.In conclusion, we have uncovered developmental properties that underlie the molar's capacity for repeated phenotypic change, or said differently, that underlie a "line of least resistance".By focusing on the developmental basis of fine phenotypic variation, our study also challenges some common assumptions and practices in developmental and evolutionary developmental biology.

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Section: The Premolar Signaling Center Persists Longer In Duhi Than Isupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Developmental variability drives mouse molar evolution along an evolutionary line of least resistance

Hayden

Lochovska

Sémon

et al. 2019

Preprint

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“…It has been previously reported that two successive and transient bud‐like structures in the diastema may be the rudimentary precursors of the premolars present in ancestral species (Prochazka et al, ). These rudimentary buds can develop into a supernumerary tooth in several mutants (Klein et al, ; Lochovska et al, ). It will be interesting to further investigate if the expanded tooth germ upon increased Shh activity can contribute to supernumerary tooth formation.…”

Section: Molar Progenitor Cell Migrationmentioning

confidence: 99%

From snapshots to movies: Understanding early tooth development in four dimensions

Kim

Green

Klein

2017

Developmental Dynamics

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The developing tooth offers a model for the study of ectodermal appendage organogenesis. The signaling networks that regulate tooth development have been intensively investigated, but how cell biological responses to signaling pathways regulate dental morphogenesis remains an open question. The increasing use of ex vivo imaging techniques has enabled live tracking of cell behaviors over time in high resolution. While recent studies using these techniques have improved our understanding of tooth morphogenesis, important gaps remain that require additional investigation. In addition, some discrepancies have arisen between recent studies, and resolving these will advance our knowledge of tooth development.

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“…chr5: 141405828 is located in the γ-protocadherin (PCDHG@) gene cluster, which is believed to modulate regulatory pathways critical for development, such as Wnt signalling [Dallosso et al, 2009], which is also critical at all stages of tooth development. rs66756037 is located near the genes fibroblast growth factor 1 (FGF1) and sprouty RTK signalling antagonist 4 (SPRY4), both of which are involved in tooth development [Thesleff et al, 2001;Lochovska et al, 2015]. In regions 2q37 and 10q21.1, there were clusters of 16 and 19 suggestively significant SNPs, respectively.…”

Section: Gwas On Malesmentioning

confidence: 99%

Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort

et al. 2018

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Erosive tooth wear is defined as irreversible loss of dental tissues due to intrinsic or extrinsic acids, exacerbated by mechanical forces. Recent studies have suggested a higher prevalence of erosive tooth wear in males, as well as a genetic contribution to susceptibility to erosive tooth wear. Our aim was to examine erosive tooth wear by performing a genome-wide association study (GWAS) in a sample of the Northern Finland Birth Cohort 1966 (n = 1,962). Erosive tooth wear was assessed clinically using the basic erosive wear examination. A GWAS was performed for the whole sample as well as separately for males and females. We identified one genome-wide significant signal (rs11681214) in the GWAS of the whole sample near the genes PXDN and MYT1L. When the sample was stratified by sex, the strongest genome-wide significant signals were observed in or near the genes FGFR1, C8orf86, CDH4, SCD5, F2R, and ING1. Additionally, multiple suggestive association signals were detected in all GWASs performed. Many of the signals were in or near the genes putatively related to oral environment or tooth development, and some were near the regions considered to be associated with dental caries, such as 2p24, 4q21, and 13q33. Replications of these associations in other samples, as well as experimental studies to determine the biological functions of associated genetic variants, are needed.

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Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation

Cited by 15 publications

References 42 publications

Developmental variability drives mouse molar evolution along an evolutionary line of least resistance

Developmental variability drives mouse molar evolution along an evolutionary line of least resistance

From snapshots to movies: Understanding early tooth development in four dimensions

Genome-Wide Association Study of Erosive Tooth Wear in a Finnish Cohort

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