Spur cell anemia in end-stage liver disease: a zebra!

Shah, Rushikesh; Patel, Arpan; John, Savio

doi:10.1016/j.ajem.2014.01.027

Cited by 6 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vassiliadis et al reported a 25-day median survival rate in the 9 patients with SCA, and only one patient, who had undergone liver transplantation, had survived after 1 year [12]. To our knowledge, there have been 24 case reports on 26 patients with SCA since 1983 including our case (Table 3) [13,14,16,19,20,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. On reviewing these cases, the average age was 42.6 years old, and 14 (53.8%) of the 26 patients were men.…”

Section: Discussionmentioning

confidence: 66%

Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review

Miwa

Hatano

Kochi

et al. 2020

Clin J Gastroenterol

View full text Add to dashboard Cite

Spur cell anemia is an acquired hemolytic anemia associated with liver cirrhosis and is characterized by the presence of increased large red blood cells, which are covered with spike-like projections that vary in width, length, and distribution. A 26-year-old man was referred to our hospital presenting with jaundice, lower limb edema, and dyspnea. The patient was subsequently diagnosed with spur cell anemia related to alcoholic liver cirrhosis. Spur cell anemia is an independent predictor of mortality in liver cirrhosis and has been associated with extremely poor prognosis. The most effective treatment for spur cell anemia is liver transplantation. As seen in the literature, the treatment of spur cell anemia without liver transplantation is quite challenging. This report highlights the importance of management and treatment strategies, including control of fluid retention, blood transfusion, plasma diafiltration, and administration of diuretics. Our treatment strategies might be useful in patients who are not candidate of liver transplantation or patients waiting for liver transplantation.

show abstract

Section: Discussionmentioning

confidence: 66%

Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review

Miwa

Hatano

Kochi

et al. 2020

Clin J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Although anemia can be seen in up to two-thirds of cirrhotic patients 3 , hemolysis is relatively infrequent. Spur cell anemia (SCA) and Zieve’s syndrome (ZS) tend to be the most important considerations in the setting of chronic alcoholism, liver disease, and non-immune mediated hemolysis 4 . Due to drastically different treatment approaches, distinguishing the two is of utmost importance.…”

Section: Discussionmentioning

confidence: 99%

An Unusual Case of Hemolytic Anemia Reversed with Liver Transplantation

Katiyar¹,

Dadlani²,

Vohra³

et al. 2022

IJHOSCR

View full text Add to dashboard Cite

Spur cell anemia is acquired hemolytic anemia seen in patients with advanced liver disease, particularly in the setting of alcoholism, and warrants urgent liver transplant evaluation. We describe the case of a 58-year-old female with alcoholic cirrhosis who presented with worsening liver disease, profound anemia poorly responsive to blood transfusions, and multiple spur cells on the peripheral smear. She underwent a liver transplant, which led to the resolution of hematologic abnormalities and the need for transfusions. Our case highlights the significance of spur cell anemia as a harbinger of poor prognosis in patients with advanced liver disease and its reversibility with liver transplantation.

show abstract

“…In contrast, patients with spur cell anemia require urgent orthotopic liver transplantation for survival. [3,12] Thus, early diagnosis is crucial.…”

Section: Discussionmentioning

confidence: 99%

Rare cause of non-immune hemolytic anemia in end-stage liver disease

Sangha

Aggarwal

Sandhu

2020

CRIM

View full text Add to dashboard Cite

Spur cells are reportedly linked to advanced end-stage liver diseases and may lead to accelerated hemolysis. In this case report, we discuss one of these rare instances when a 45-year-old female with decompensated cirrhosis was admitted for severe anemia. Extensive workup revealed non-immune hemolysis secondary to spur cell formation. Orthotopic liver transplantation remains the only treatment of choice for reversal of spur cell anemia. Alternatively, multidrug therapy has also been explored, including usage of bile acid sequestrants; however, success is rare.

show abstract

Spur cell anemia in end-stage liver disease: a zebra!

Cited by 6 publications

References 4 publications

Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review

Spur cell anemia related to alcoholic liver cirrhosis managed without liver transplantation: a case report and literature review

An Unusual Case of Hemolytic Anemia Reversed with Liver Transplantation

Rare cause of non-immune hemolytic anemia in end-stage liver disease

Contact Info

Product

Resources

About