Sputum Cytologic Diagnosis of Hodgkin's Disease Involving the Lung

Giangreco, A.

doi:10.1001/archinte.1980.00040020910007

Cited by 6 publications

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An emphasis on complete remission, even in patients who relapse after treatment, has led to increased disease-free survival. 7 With improved recognition of cells that can be diagnostic of HD, cytodiagnosis is considered as an important adjunctive method in the evaluation of patients with known HD and new pulmonary lesions.…”

Section: Dear Dr Bedrossianmentioning

confidence: 99%

Reed-sternberg cells in bronchial brushings from a patient with Hodgkin's disease

2006

View full text Add to dashboard Cite

A 59-yr-old male with stage IV Hodgkin's lymphoma of nodular sclerosing type was admitted to our institution approximately 9 mo after initial diagnosis with complaints of fever, chills, and fatigue. The patient had recently completed a cycle of multidrug chemotherapy. Laboratory data upon admission demonstrated leukocytosis with neutrophilia and mild anemia, and a chest X-ray illustrated right upper lobe and left midlung opacities. A bronchoscopy with cytologic brushings was subsequently performed.Cytologic analysis demonstrated isolated large mononucleated variants of Reed-Sternberg cells, some of which were bilobed (Fig. 1). This unexpected finding prompted a follow-up CT-guided FNA of the left upper midlung lesion, which further supported the diagnosis of Hodgkin's disease (HD).Pulmonary involvement occurring in the course of HD is common. Clinical studies suggest that HD involves the lung in approximately 40% of patients and usually represents an extension of disease originating in the mediastinum, 1 although rare cases of primary pulmonary HD have been described. 2,3 It has been reported previously that, of the various subtypes of HD, the nodular sclerosing variety is most often associated with pulmonary parenchymal involvement as seen by radiography. 4 The development of lung lesions seen on X-ray in a patient with HD presents the clinician with a diagnostic problem, since radiologic features of pulmonary HD are variable and nonspecific and may resemble opportunistic pulmonary infections or lung abnormalities induced by chemotherapy or radiotherapy. In this situation, the prognostic and therapeutic implications of establishing a correct diagnosis are of great importance. Cytology of sputum or bronchial washings/brushings may reveal diagnostic Reed-Sternberg cells and establish the diagnosis of pulmonary HD, obviating the need for more aggressive surgical procedures.

show abstract

Section: Dear Dr Bedrossianmentioning

confidence: 99%

Reed-sternberg cells in bronchial brushings from a patient with Hodgkin's disease

2006

View full text Add to dashboard Cite

show abstract

“…Patients with HD and a positive bronchoscopy, had lymphoma which was confined to the thorax, whilst in NHL all but one patient had widely disseminated disease outside the chest. Although there are reports of the diagnosis of both HD and NHL on sputum cytology (Giangreco et al, 1980;Supron & Kross, 1964) these have all been in patients with advanced disease. By contrast in this group with newly diagnosed lymphoma the appearances at bronchoscopy, biopsy, and cytology all showed that the surface epithelium remained intact over the lymphomatous deposits.…”

Section: Discussionmentioning

confidence: 99%

Early involvement of the bronchi in patients with malignant lymphoma

Gallagher¹,

Knowles²,

Habeshaw³

et al. 1983

Br J Cancer

View full text Add to dashboard Cite

Fibreoptic bronchoscopy in previously untreated patients with malignant lymphoma provided diagnostic information in 8 of 25 cases with radiological evidence of intrathoracic involvement. There was a marked difference in the pattern of endobronchial involvement between Hodgkin's Disease (HD) and Non Hodgkin's Lymphoma (NHL) which specifically infiltrated the bronchus-associated lymphoid tissue. Bronchoalveolar lavage was abnormal in only one patient with Hodgkin's Disease in whom the presence of many Sternberg-Reed cells suggested occult dissemination of otherwise localised disease. Images Figure 1 Figure 2

show abstract