Sputum cytology in suspected cases of carcinoma of lung (Sputum cytology a poor man′s bronchoscopy!)

Ammanagi, A S; Dombale, Vijay; Miskin, AT; Dandagi, G L; Sangolli, S S

doi:10.4103/0970-2113.92356

Cited by 35 publications

(17 citation statements)

References 22 publications

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“…In some countries, sputum analysis is considered 'a poor men's bronchoscopy' [45], as it provides a more affordable but still reliable method for lung cancer diagnosis in low-income areas. If sputum EGFR mutation analysis alone is required, sputum analysis may be done in order to avoid in some patients a biopsy procedure.…”

Section: Discussionmentioning

confidence: 99%

EGFR mutation analysis in sputum of lung cancer patients: A multitechnique study

et al. 2013

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Section: Discussionmentioning

confidence: 99%

EGFR mutation analysis in sputum of lung cancer patients: A multitechnique study

et al. 2013

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“…Sputum cytology examination is useful for early detection in populations at high risk for lung cancer. 27 Ammanagi et al 28 included 36 patients with clinically suspected carcinoma of lung in their study. Twenty cases were confirmed as lung malignancy by histopathologic and/or radiographic and clinical evidences.…”

Section: Discussionmentioning

confidence: 99%

Exfoliative cytology analysis from different sites of the body

et al. 2017

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Background: Cytological study of body fluids a non-invasive, simple procedure, relatively inexpensive, and helps in faster reporting that has high population acceptance. The present study aims to determine the proportion of malignant and non malignant lesions. Methods: A total of 1129 specimens of exfoliative cytology were examined during the period over five years from year January 2011 to December 2016 at Department of Pathology at Chitwan Medical College Teaching Hospital, Nepal. The fluid received was centrifuged at 3000 revolutions per minute for five minutes. Smears were made from the sediment. Two to three slides were air dried and stained with Giemsa stain. One slide was immediately fixed in 95% alcohol and stained with Papanicolaou (Pap) stain for cytological evaluation. Results: Pleural fluid was most common specimen (49.3%) with peritoneal fluid (32%), pericardial fluid (1%), BAL (7.8%), CSF (4%), sputum (3.4%), synovial fluid (2%) and urine (0.5%) specimens. Male to female ratio was 1.33:1. Maximum cases belonged to age group of 50-69 years. Only (5.8%) 67 cases were neoplastic. The maximum cases of malignant neoplasm were detected in pericardial fluid and pleural fluid, each 21 (1.8%) cases, and 20 (1.7%) cases BAL. Malignant effusions were detected in 46 (4%) cases. Maximum malignant cases were adenocarcinoma (71.6%), followed by squamous cell carcinoma (20.8%). Conclusion: Exfoliative cytology should be suggested in all cases of effusion and suspected malignancies which helps in reaching at a particular diagnosis and aids in further management.

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“…In the clinical diagnostic setting, the sensitivity of sputum cytology is ∼60%, which also depends on the number of sputum samples examined (Risse et al , 1985). Although in developed countries the procurement of tumour biopsies/tumour cytology replaced the use of sputum cytology as standard for lung cancer diagnosis (Rivera and Mehta, 2007), in lower budget countries sputum cytology is an affordable diagnostic instrument and still clinically implemented (Ammanagi et al , 2012). …”

Section: Sputum Cytologymentioning

confidence: 99%

Molecular sputum analysis for the diagnosis of lung cancer

et al. 2013

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Lung cancer is the leading cause of cancer mortality rate worldwide, mainly because of the presence of metastatic disease at the time of diagnosis. Early detection of lung cancer improves prognosis, and towards this end, large screening trials in high-risk individuals have been conducted since the past century. Despite all efforts, the need for novel (complementary) lung cancer diagnostic and screening methods still exists. In this review, we focus on the assessment of lung cancer-related biomarkers in sputum in the past decennium. Besides cytology, mutation and microRNA analysis, special attention has been paid to DNA promoter hypermethylation, of which all available literature is summarised without time restriction. A model is proposed to aid in the distinction between diagnostic and risk markers. Research on the use of sputum for non-invasive detection of early-stage lung cancer has brought new insights and advanced molecular techniques. The sputum shows a promising potential for routine diagnostic and possibly screening purposes.

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Sputum cytology in suspected cases of carcinoma of lung (Sputum cytology a poor man′s bronchoscopy!)

Cited by 35 publications

References 22 publications

EGFR mutation analysis in sputum of lung cancer patients: A multitechnique study

EGFR mutation analysis in sputum of lung cancer patients: A multitechnique study

Exfoliative cytology analysis from different sites of the body

Molecular sputum analysis for the diagnosis of lung cancer

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