Sputum‐to‐serum hydrogen sulphide ratio as a novel biomarker of predicting future risks of asthma exacerbation

Abstract

The H S ratio may provide useful information on predicting future risks of asthma exacerbation, as well as on obstructive neutrophilic airway inflammation as one of the non-Th2 biomarkers, in asthma.

Developments in the field of clinical allergy in 2018 through the eyes of Clinical and Experimental Allergy, Part II

“…In this study of asthmatics of varying severity, healthy subjects' serum and sputum H 2 S have been examined. 57 Serum levels were lower and sputum levels higher in those with frequent exacerbations compared to those with fewer and elevated sputum H 2 S predicted future exacerbations. Thus, a higher ratio of sputum to serum H 2 S seems to predict more exacerbations though it is entirely unclear why H 2 S should behave in this way.…”

“…H 2 S has recently been shown to be an important gaseous signalling molecule involved in modulating airway and vascular smooth muscle. In this study of asthmatics of varying severity, healthy subjects' serum and sputum H 2 S have been examined . Serum levels were lower and sputum levels higher in those with frequent exacerbations compared to those with fewer and elevated sputum H 2 S predicted future exacerbations.…”

Reactive sulfur species and their significance in health and disease

“…There can be some possible reasons for this discrepancy including different methods used for H 2 S assay and various factors which can influence the H 2 S level, such as exacerbation of disease and degree of inflammation. In parallel, the level of H 2 S in asthmatic patients measured in the sputum was clearly elevated compared with healthy donors: 26–27 μM vs.11.4 μM [ 138 , 140 ] and 31.9 μM vs 19.7 μM [ 141 , 142 ], ( Table 2 ). It seems that sputum H 2 S particularly correlates with the degree of airflow limitation and it has been suggested that H 2 S has potential as a novel biomarker for COPD and asthma [ 140 ].…”

Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease

“…Macrophages from sputum samples of asthma patients express reduced levels of Gal-1 and Gal-9 (82). Several human studies have shown a decrease in serum or exhaled-breath H 2 S levels in both adult and infants (220–222). Moreover, lower H 2 S levels are correlated with abnormal pulmonary lung function tests and severity of asthma (220, 221).…”