According to previous research, endoscopists often suffer from musculoskeletal injuries (MI). There is little evidence from many nations. Endoscopists often experience physical stress, which may cause musculoskeletal issues. Work-related musculoskeletal diseases have gained attention due to the growing complexity of interventional endoscopy and the lengthened examination times. Data on endoscopists' health stress at work, however, is hard to come by. Therefore, the aim of this research was to look at the effects and incidence of work-related musculoskeletal problems among endoscopists. The purpose of the research was to evaluate, in a nationally representative population, the incidence of self-reported endoscopy-related injuries, injury patterns, and endoscopist awareness of prevention interventions. A questionnaire on musculoskeletal illnesses related to endoscopy and standardised pain evaluation was created and data was collected from endoscopic staff of multispecialty hospital in national capital region. Relevant risk variables for musculoskeletal health problems have been identified as being age, professional experience, and work hours. The findings revealed that the participants had a mean professional experience of 21.0 years and had an average daily working time of 8.2 hours in the endoscopic facilities. The dominant hand utilised in endoscopic operations is the right hand (n = 134; 89.33%) rather than the left (n = 9; 6%). Due to certain working postures and repeated actions that have a significant negative influence on one's health, a big percentage of endoscopists suffer from musculoskeletal problems. To enhance the prevention of risk of the endoscopic activity, further interventional investigations are necessary.