Squamotransitional Cell Carcinoma of the Vagina: Diagnosis and Clinical Management

Patrelli, Tito Silvio; Silini, Enrico Maria; Berretta, Roberto; Thai, Elena; Gizzo, Salvatore; Modena, Alberto Bacchi; Nardelli, Giovanni Battista

doi:10.1007/s12253-010-9280-8

Cited by 9 publications

(5 citation statements)

References 22 publications

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“…Our data support the statement by Patrelli TS et al [18] that leading factors for the diagnosis are the morphology and cytoarchitectural features of this type of tumor. The morphological findings are consistent with mitotically active tumors with solid and/or inverted papillary growth patterns, composed of polygonal cells demonstrating transitional cell features (with hyperchromatic, oval, grooved nuclei and a relatively small amount of cytoplasm) showing focal squamous differentiation.…”

Section: Site(s) Involved Positive Expression Negative Expressionsupporting

confidence: 92%

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Squamotransitional Cell Carcinoma of the Uterine Cervix with Ovarian Metastasis and Benign Brenner Tumor: A Case Report

Yordanov,

Karaivanov,

Ivanov

et al. 2023

Reports

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Introduction: Cervical cancer is the fourth most common malignancy in women and the fourth leading cause of death among women. The main histological types of cervical cancer are squamous cell carcinoma—75% of all cases; adenocarcinoma—10–25%; and all other rare variants including adenosquamous carcinoma and neuroendocrine carcinoma. Squamotransitional cervical cancer is an extremely rare and poorly studied subtype of squamous cell carcinoma. Case report: We present a case of a 64-year-old female patient with early-stage squamotransitional carcinoma. A metastasis was observed in the left ovary and the left fallopian tube and a benign Brenner tumor in the right ovary. Discussion: Although it is believed that this cervical cancer subtype shares the same risk factors and prognosis as squamous cell carcinoma, it is more likely to metastasize and recur. It is not unusual for spread to exist within nearby structures like the cervix and adnexa. It is impossible to tell which is the predominant focus from the immunoprofile of the lesions. Practically speaking, the best course of action in these situations is to rule out the presence of a primary tumor in the urinary tract before clarifying the condition of the cervix, uterus, and adnexal tissues. The presence of a Brenner tumor raises the possibility of a connection between the tumor’s differentiation from a cell population and potential urothelial differentiation. Conclusion: Squamotransitional cervical cancer is a rare tumor with a poorly studied clinical behavior. Despite a shortage of information in the literature, it should be regarded as a more aggressive variety of squamous cell carcinoma and, as such, should be treated and followed up more aggressively. This case is the first described with involvement of the cervix, endometrium, and adnexal structures and a concomitant Brenner tumor.

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Section: Site(s) Involved Positive Expression Negative Expressionsupporting

confidence: 92%

“…Patrelli TS et al [18] squamous urothelial carcinoma vagina one site was involved (no spread of the disease) CK 7, p16 ink4a, p63 CK 20…”

Section: Site(s) Involved Positive Expression Negative Expressionmentioning

confidence: 99%

Squamotransitional Cell Carcinoma of the Uterine Cervix with Ovarian Metastasis and Benign Brenner Tumor: A Case Report

Yordanov,

Karaivanov,

Ivanov

et al. 2023

Reports

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“…Other histological types, such as neuroendocrine carcinomas [9,10] and papillary squamo-transitional cell carcinomas [11], are exceptional.…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma of the vagina: natural history, treatment modalities and prognostic factors

Gadducci

Fabrini

Lanfredini

et al. 2015

Critical Reviews in Oncology/Hematology

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“…However, few cases of vaginal TCC that occur synchronously or metachronously with non-muscle invasive TCC of the urinary tract have been described (9,10). In addition, the extremely rare entity of primary vaginal TCC in the absence of a urinary tract tumor has also been reported (11)(12)(13). The pathogeneses of these variable clinical scenarios appear to be varied; however, the small number of cases in each group renders establishing the pathogenesis challenging.…”

Section: Discussionmentioning

confidence: 99%

Bladder and vaginal transitional cell carcinoma: A case report

et al. 2016

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Abstract. The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC cases. The pathogenesis of vaginal TCC is challenging to determine, although it is essential for the adequate management of the tumor and to determine the appropriate treatment. The present study reports a case of bladder TCC and metachronous vaginal TCC. The patient had a history of high risk non muscle invasive bladder cancer treated by BCG and presented with a recurrent carcinoma in situ. A novel cycle of BCG was initiated but the patient had a persistent disease and a palpable mass on bimanual examination. Radical anterior pelvectomy and bilateral pelvic and inguinal lymph node dissection was performed revealing the presence of TCC of the bladder neck and the invasion into the anterior vaginal wall. The differences between local vaginal invasion and the metastatic spread from a primary bladder TCC, the occurrence of a second primary vaginal tumor and the direct implantation of TCC via urine that contains transitional cancer cells were reviewed and analyzed. Finally, a management plan was determined.

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Squamotransitional Cell Carcinoma of the Vagina: Diagnosis and Clinical Management

Cited by 9 publications

References 22 publications

Squamotransitional Cell Carcinoma of the Uterine Cervix with Ovarian Metastasis and Benign Brenner Tumor: A Case Report

Squamotransitional Cell Carcinoma of the Uterine Cervix with Ovarian Metastasis and Benign Brenner Tumor: A Case Report

Squamous cell carcinoma of the vagina: natural history, treatment modalities and prognostic factors

Bladder and vaginal transitional cell carcinoma: A case report

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