1988
DOI: 10.1016/s0002-9610(88)80292-7
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Squamous carcinoma of the gums

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Cited by 115 publications
(77 citation statements)
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“…2 This is despite current evidence suggesting that bone invasion is not an independent prognostic factor when confounding variables such as tumor size and involved surgical margins are taken into consideration. [4][5][6]9 However, the studies to date are generally limited by small sample sizes and failure to distinguish between cortical and medullary invasion, making it difficult to derive any definitive conclusions. The present study reconciles the difference between prior studies and expert opinion by demonstrating that only medullary bone invasion is an adverse prognostic feature after adjusting for potential confounding variables in a study with sufficient power.…”
Section: Discussionmentioning
confidence: 99%
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“…2 This is despite current evidence suggesting that bone invasion is not an independent prognostic factor when confounding variables such as tumor size and involved surgical margins are taken into consideration. [4][5][6]9 However, the studies to date are generally limited by small sample sizes and failure to distinguish between cortical and medullary invasion, making it difficult to derive any definitive conclusions. The present study reconciles the difference between prior studies and expert opinion by demonstrating that only medullary bone invasion is an adverse prognostic feature after adjusting for potential confounding variables in a study with sufficient power.…”
Section: Discussionmentioning
confidence: 99%
“…This is in keeping with previous studies that classified bone invasion in this way and found no association with adverse outcomes. 4,6,8,9 The exception to this was a retrospective analysis by Jones et al of 82 patients with oral and oropharyngeal SCC undergoing mandibulectomy. 7 However, 31 (93.9%) of 33 patients with bone invasion had oral cancer in this study, compared with 17 (34.7%) of 49 patients without bone invasion, introducing primary site as a potential confounding factor.…”
Section: Discussionmentioning
confidence: 99%
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