Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment

Becker, Christoph; Kayser, Gian; Pfeiffer, Jens

doi:10.1002/hed.24391

Cited by 35 publications

(59 citation statements)

References 28 publications

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“…So far, only few data exist regarding the impact of HPV positivity in nasal SCCs. HPV positivity was reported in 10 up to 62% of carcinomas [3, 12] and former works demonstrated that HPV positivity was a favorable prognostic factor for nasal SCCs [12, 13]. Chowdhury et al showed that median overall survival was 54 months in HPV positive compared to 12 months in HPV negative sinonasal SCCs [12].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, due to unspecific and partially overlapping anatomic boundaries and definitions in nasal cavity, it is sometimes difficult to clearly allocate SCCs to distinct anatomic subsites. As already raised by Becker et al, unselected analysis of carcinomas of the nasal cavity, paranasal sinuses and nasal vestibule, without differentiation according to anatomic subsites, cause inhomogeneous results, which may lead to wrong conclusions [3]. Therefore, all patients with uncertain or incomplete data regarding tumor subsite were excluded from analysis a priori to obtain a homogenous patient cohort.…”

Section: Discussionmentioning

confidence: 99%

“…Due to aggressive local spread, rapid growth and tendency for local and regional recurrence, management of sinonasal SCCs is challenging [2, 3]. Radical tumor resection followed by either adjuvant radiotherapy or observation represents the mainstay of therapy [4].…”

Section: Introductionmentioning

confidence: 99%

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Impact of anatomic origin of primary squamous cell carcinomas of the nasal cavity and ethmoidal sinus on clinical outcome

Janik

Gramberger

Kadletz

et al. 2018

Eur Arch Otorhinolaryngol

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PurposeSince squamous cell carcinomas (SCCs) of the nasoethmoidal complex are rare and aggressive malignancies, the purpose of this study was to evaluate whether anatomic subsites of SCCs of the nasal cavity and ethmoid sinuses affect clinical outcome.MethodsWe retrospectively analyzed data from 47 patients with primary SCCs of the nasal cavity and ethmoid sinuses who were treated at the Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, between 1993 and 2018. The impact of anatomic subsites of nasoethmoidal SCCs was evaluated with respect to tumor and nodal classification, disease-free survival (DFS) and disease-specific survival (DSS).ResultsOf the 47 cases, 17 SCCs (36.2%) originated from lateral nasal wall followed by 13 (27.7%) tumors of the edge of naris to mucocutaneous junction, 11 (23.4%) SCCs of the nasal septum, 3 tumors of the nasal floor (6.4%) and 3 SCCs of the ethmoid sinuses (6.4%), respectively. SCCs of the nasal septum were associated with significantly higher rates of neck node metastasis (p = 0.007), which represented a significantly worse prognostic factor for DSS (HR 7.87; p < 0.001). Moreover, advanced tumor stage (HR 5.38; p = 0.014) and tumor origin of nasal septum (HR 4.05; p = 0.025) were also significantly worse prognostic factors for DSS. Fourteen patients (29.8%) developed recurrent disease, including eight local (17.0%), five regional (10.6%) and one distant (2.1%) recurrence. Elective neck dissection (ND) was associated with lower (0 vs. 20.0%) but not significantly different regional and distant DFS (p = 0.075).ConclusionAnatomic origin of nasal SCC has significant impact on clinical outcome. SCCs of the nasal septum were associated with higher rates of positive neck nodes and worse outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Impact of anatomic origin of primary squamous cell carcinomas of the nasal cavity and ethmoidal sinus on clinical outcome

Janik

Gramberger

Kadletz

et al. 2018

Eur Arch Otorhinolaryngol

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“…At last, maxillary osteolysis can be observed in malignant tumors like mucoepidermoid carninoma, squamous-cell carcinoma and lymphoma [19, 20]. Extranodal NK/T-cell lymphoma associated with Epstein-Barr virus infection has to be highlighted because of its severity and the difficulties to diagnose it.…”

Section: Discussionmentioning

confidence: 99%

Case of disseminated histoplasmosis in a HIV-infected patient revealed by nasal involvement with maxillary osteolysis

et al. 2017

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BackgroundDisseminated Histoplasmosis (DH) is a rare manifestation of Acquired Immune Deficiency Syndrome (AIDS) in European countries. Naso-maxillar osteolysis due to Histoplasma capsulatum var. capsulatum (Hcc) is unusual in endemic countries and has never been reported in European countries. Differential diagnoses such as malignant tumors, cocaine use, granulomatosis, vasculitis and infections are more frequently observed and could delay and/or bias the final diagnosis.Case presentationWe report the case of an immunocompromised patient infected by Human Immunodeficiency Virus (HIV) with naso-maxillar histoplasmosis in a non-endemic country. Our aim is to describe the clinical presentation, the diagnostic and therapeutic issues. A 53-year-old woman, originated from Haiti, was admitted in 2016 for nasal deformation with alteration of general condition evolving for at least 6 months. HIV infection was diagnosed in 2006 and classified at AIDS stage in 2008 due to cytomegalovirus infection associated with pulmonary histoplasmosis. At admission, CD4 cell count was 9/mm3. Surgical biopsies were performed and ruled out differential or associated diagnoses. Mycological cultures identified Hcc and Blood Polymerase Chain Reaction (PCR) for Hcc was positive. The patient was given daily Amphothericin B liposomal infusion during 1 month. Hcc PCR became negative in the blood under treatment, and then oral switch by itraconazole was introduced. Antiretroviral treatment was reintroduced after a 3-week histoplasmosis treatment. Normalization of naso-maxillar mucosa enabled a palatal prosthesis.ConclusionNaso-maxillar histoplasmosis is extremely rare; this is the first case ever reported in a non-endemic country. Differential diagnoses must be ruled out by conducting microbiologic tools and histological examinations on surgical biopsies. Early antifungal treatment should be initiated in order to prevent DH severe outcomes.

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“…1,2 Squamous cell carcinoma is the most common histology, followed by adenoid cystic and adenocarcinoma. 3,4 Another distinctive feature of septal cancer is the lack of consensus regarding its classification. 3,4 Another distinctive feature of septal cancer is the lack of consensus regarding its classification.…”

Section: Introductionmentioning

confidence: 99%

Microscopic tumor invasion of contralateral mucosa in cancer involving unilateral septum

et al. 2019

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Background Preservation of contralateral mucosa with microscopic tumor invasion in unilateral septal involvement increases the recurrence risk. The purpose of this study was to analyze the risk of invasion of contralateral mucosa in unilateral septal involvement of cancer and to risk stratify patients. Methods Retrospective chart review of patients with histologically proven malignancy with unilateral septal involvement and absence of gross septal tumor involvement on the contralateral side were included. Results Among 40 patients, majority (55%) belonged to sixth and seventh decade. The most common type was squamous cell carcinoma (63%). Approximately one‐fourth (23%) showed microscopic contralateral invasion. Females (OR 12; 95% CI 2.01‐71.35) and patients with septal bone invasion (OR 28.5; CI 3.35‐242.0) had a higher risk of developing contralateral mucosal invasion. Conclusion Complete resection of contralateral mucosa is preferred in areas along the bony septum. When complete resection is not performed, intraoperative frozen section is strongly recommended.

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Squamous cell cancer of the nasal cavity: New insights and implications for diagnosis and treatment

Cited by 35 publications

References 28 publications

Impact of anatomic origin of primary squamous cell carcinomas of the nasal cavity and ethmoidal sinus on clinical outcome

Impact of anatomic origin of primary squamous cell carcinomas of the nasal cavity and ethmoidal sinus on clinical outcome

Case of disseminated histoplasmosis in a HIV-infected patient revealed by nasal involvement with maxillary osteolysis

Microscopic tumor invasion of contralateral mucosa in cancer involving unilateral septum

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