Squamous cell carcinoma arising from a seminal vesicular cyst: Possible relationship between chronic inflammation and tumor development

Yanagisawa, Nobuyuki; Saegusa, Makoto; Yoshida, Tsutomu; Okayasu, Isao

doi:10.1046/j.1440-1827.2002.01340.x

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…LPS-induced TLR4 signaling pathways showed that TLR4, CD14 and Myd88 complexes were the indispensable components to recognize LPS [9,10,11,12]. Additionally, it has demonstrated that LPS treatment not only affected immune cells such as T cells and macrophage, but also had an impact on many types of epithelial cells through TLR4 signaling, which led to local infections or inflammatory processes [13]. Intestinal epithelial cells (IECs) play an active role in the mucosal immune response to pathogenic bacteria, which mediate the non-specific acute inflammatory response [14].…”

Section: Introductionmentioning

confidence: 99%

L-Arginine Inhibited Inflammatory Response and Oxidative Stress Induced by Lipopolysaccharide via Arginase-1 Signaling in IPEC-J2 Cells

Qiu

Yang

Wang

et al. 2019

IJMS

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This study aimed to explore the effect of L-arginine on lipopolysaccharide (LPS)-induced inflammatory response and oxidative stress in IPEC-2 cells. We found that the expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), cluster of differentiation 14 (CD14), nuclear factor-kappaBp65 (NF-κBp65), chemokine-8 (IL-8), tumor necrosis factor (TNF-α) and chemokine-6 (IL-6) mRNA were significantly increased by LPS. Exposure to LPS induced oxidative stress as reactive oxygen species (ROS) and malonaldehyde (MDA) production were increased while glutathione peroxidase (GSH-Px) were decreased in LPS-treated cells compared to those in the control. LPS administration also effectively induced cell growth inhibition through induction of G0/G1 cell cycle arrest. However, compared with the LPS group, cells co-treatment with L-arginine effectively increased cell viability and promoted the cell cycle into the S phase; L-arginine exhibited an anti-inflammatory effect in alleviating inflammation induced by LPS by reducing the abundance of TLR4, MyD88, CD14, NF-κBp65, and IL-8 transcripts. Cells treated with LPS+L-arginine significantly enhanced the content of GSH-Px, while they decreased the production of ROS and MDA compared with the LPS group. Furthermore, L-arginine increased the activity of arginase-1 (Arg-1), while Arg-1 inhibitor abolished the protection of arginine against LPS-induced inflammation and oxidative stress. Taken together, these results suggested that L-arginine exerted its anti-inflammatory and antioxidant effects to protect IPEC-J2 cells from inflammatory response and oxidative stress challenged by LPS at least partly via the Arg-1 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

L-Arginine Inhibited Inflammatory Response and Oxidative Stress Induced by Lipopolysaccharide via Arginase-1 Signaling in IPEC-J2 Cells

Qiu

Yang

Wang

et al. 2019

IJMS

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“…Prolonged chronic inflammation induced DNA damage and the induction of squamous metaplastic changes may play an important role during the pathogenesis of SCC. [3]…”

Section: Discussionmentioning

confidence: 99%

“…To date, no more than 5 cases of primary SCC arising from the seminal vesicle have been reported. [3–7] Through reviewing the literature, we summarized these cases between 2002 and 2016 (Table 1). Patient age at the time of diagnosis ranged from 26 to 69 years, with a mean age at 50 years.…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the seminal vesicle

et al. 2019

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Rationale: Primary squamous cell carcinoma (SCC) of the seminal vesicle is extremely rare, and the clinical characteristics of this kind of malignancy are still unclear. Patient concerns: A 62-year-old male patient presented with complaints of sensation of rectal tenesmus and dysuria. Diagnosis: Ultrasonography suggested a hypoechoic mass behind the bladder, meanwhile, computerized tomography (CT) and magnetic resonance imaging (MRI) revealed a 40 mm × 45 mm × 48 mm mixed solid/cystic tumorous lesion in the right seminal vesicle. Postoperative histology confirmed the diagnosis of primary SCC in the seminal vesicle. Intervention: The mass was surgically excised with a laparoscopic approach. Postoperatively, 6 cycles of chemotherapy and 50 Gy of external beam radiation were concurrently performed on this patient. Outcomes: No local recurrence or distant metastasis was detected within 2 years after the surgery. Lessons: Primary SCC of the seminal vesicle is a rare neoplasm with a poor prognosis. Clinically, it is crucial to establish early precise diagnosis and apply multimodality treatment.

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“…Histologically, the seminal vesicles are composed of an external fibrous connective tissue layer, a middle smooth muscle layer and an inner mucosal layer (6). The squamous cell tumor in the seminal vesicle may be due to chronic inflammatory stimulation-induced squamous metaplasia and subsequent malignant transformation (7). Primary SCC of the seminal vesicle is extremely rare, with only two cases reported in the English literature to date (1,2).…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the seminal vesicle: A case report

Tang

Sun

Tian

et al. 2015

Molecular and Clinical Oncology

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Primary squamous cell carcinoma (SCC) is extremely rare in the seminal vesicle. A 26-year-old male patient presented with complaints of difficulty in urination for 10 years and gross hematuria for 7 months. Ultrasonography and computed tomography imaging demonstrated a large mixed solid/cystic mass lesions in the rectovesical pouch. The mass was completely resected with the open approach and was verified as a primary SCC of the seminal vesicle by post-surgical histopathological examination. Pelvic metastases were detected 28 months after the surgery. This is the third reported case of primary SCC of the seminal vesicle, and the first one in a young patient. Early diagnosis and treatment are crucial for primary SCC of the seminal vesicle.

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Squamous cell carcinoma arising from a seminal vesicular cyst: Possible relationship between chronic inflammation and tumor development

Cited by 13 publications

References 24 publications

L-Arginine Inhibited Inflammatory Response and Oxidative Stress Induced by Lipopolysaccharide via Arginase-1 Signaling in IPEC-J2 Cells

L-Arginine Inhibited Inflammatory Response and Oxidative Stress Induced by Lipopolysaccharide via Arginase-1 Signaling in IPEC-J2 Cells

Primary squamous cell carcinoma of the seminal vesicle

Primary squamous cell carcinoma of the seminal vesicle: A case report

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