Squamous Cell Carcinoma Arising from Chronic Osteomyelitis Treated by Mohs Micrographic Surgery

Kirsner, Robert S.; Garland, Larry D.

doi:10.1111/j.1524-4725.1994.tb00127.x

Cited by 38 publications

(27 citation statements)

References 9 publications

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“…Although carcinomas are documented to arise at the site of chronic wounds, they are a relatively infrequent complication (59). Similar to chronic wounds, conditional knockout of TGFβRII in stratified epithelia led to infrequent and localized tumor development only in older animals (60).…”

Section: Discussionmentioning

confidence: 99%

Attenuation of the Transforming Growth Factor β-Signaling Pathway in Chronic Venous Ulcers

Pastar

Stojadinović

Krzyzanowska

et al. 2010

Mol Med

134

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Transforming growth factor β (TGFβ) is important in inflammation, angiogenesis, reepithelialization and connective tissue regeneration during wound healing. We analyzed components of TGFβ signaling pathway in biopsies from 10 patients with nonhealing venous ulcers (VUs). Using comparative genomics of transcriptional profiles of VUs and TGFβ-treated keratinocytes, we found deregulation of TGFβ target genes in VUs. Using quantitative polymerase chain reaction (qPCR) and immunohistochemical analysis, we found suppression of TGFβRI, TGFβRII and TGFβRIII, and complete absence of phosphorylated Smad2 (pSmad2) in VU epidermis. In contrast, pSmad2 was induced in the cells of the migrating epithelial tongue of acute wounds. TGFβ-inducible transcription factors (GADD45β, ATF3 and ZFP36L1) were suppressed in VUs. Likewise, genes suppressed by TGFβ (FABP5, CSTA and S100A8) were induced in nonhealing VUs. An inhibitor of Smad signaling, Smad7 was also downregulated in VUs. We conclude that TGFβ signaling is functionally blocked in VUs by downregulation of TGFβ receptors and attenuation of Smad signaling resulting in deregulation of TGFβ target genes and consequent hyperproliferation. These data suggest that application of exogenous TGFβ may not be a beneficial treatment for VUs.

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Section: Discussionmentioning

confidence: 99%

Attenuation of the Transforming Growth Factor β-Signaling Pathway in Chronic Venous Ulcers

Pastar

Stojadinović

Krzyzanowska

et al. 2010

Mol Med

134

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“…The tumors that develop on chronic osteomyelitis are generally squamous cell carcinomas [14,[141][142][143][144][145][146][147][148][149][150][151][152].…”

Section: Chronic Osteomyelitis and Cancer Developmentmentioning

confidence: 99%

Chronic bacterial and parasitic infections and cancer: a review

Samaras

Rafailidis

Mourtzoukou

et al. 2010

J Infect Dev Ctries

112

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Background: A relatively underestimated facet of infectious diseases is the association of chronic bacterial and parasitic infections with cancer development. Therefore, we sought to evaluate the evidence regarding the association of such infections with the development of malignancy, excluding the overwhelming evidence of the association of Helicobacter pylori and cancer. Methodology: We searched Pubmed, Cochrane, and Scopus without time limits for relevant articles. Results: There is evidence that some bacterial and parasitic infections are associated with cancer development. The level of evidence of this association varies from high to low; in any case, a long time interval is mandatory for the development of cancer. A high level of evidence exists for the association of Salmonella Typhi with gallbladder and hepatobiliary carcinoma; Opisthorchis viverrini and Clonorchis sinensis with cholangiocarcinoma; Schistosoma hematobium with bladder cancer; chronic osteomyelitis with squamous cell carcinoma of the skin; and hidradenitis suppurativa with squamous cell carcinoma of the skin. In contrast, the level of evidence regarding the association of Chlamydia spp. with cancer is low. Mycobacterium tuberculosis is associated with lung cancer, albeit probably not etiopathogenetically. Conclusions: A considerable number of bacterial infections and parasitic infections are associated with the development of cancer. Further research into recognizing additional associations of bacterial and parasitic infections with cancer is mandatory.

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“…A chronic wound which undergoes malignant transformation is referred to as Marjolin's ulcer [7]. Marjolin first described this phenomenon in 1827 [7].…”

Section: Discussionmentioning

confidence: 99%

Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer

Mesgarzadeh

Farahani

Treister

2008

Journal of Tissue Viability

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Squamous Cell Carcinoma Arising from Chronic Osteomyelitis Treated by Mohs Micrographic Surgery

Cited by 38 publications

References 9 publications

Attenuation of the Transforming Growth Factor β-Signaling Pathway in Chronic Venous Ulcers

Attenuation of the Transforming Growth Factor β-Signaling Pathway in Chronic Venous Ulcers

Chronic bacterial and parasitic infections and cancer: a review

Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer

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