Squamous Cell Carcinoma in a Renal Transplant Recipient with Linear Porokeratosis

Anzai, Saburo; Takeo, Naoko; Yamaguchi, Tomiko; Sato, Toshihiro; Takasaki, Syuji; Terashi, Hiroto; Takayasu, Susumu; Takahashi, Shinichi

doi:10.1111/j.1346-8138.1999.tb03465.x

Cited by 28 publications

(20 citation statements)

References 11 publications

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“…These results provided a framework for the ultimate identiWcation of a new gene for DSAP. Except for sun exposure, several risk factors, including radioactivity, virus infection (Mizukawa and Shiohara 1999), renal transplantation (Anzai et al 1999), and bone marrow transplantation (Rio et al 1997), had been associated with the development of DSAP. However, none of the above risk factors was reported in the Chinese family under this study.…”

Section: Discussionmentioning

confidence: 99%

Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3–p31.1

et al. 2008

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Disseminated superficial actinic porokeratosis (DSAP) is a chronic autosomal dominant cutaneous disorder with high genetic heterogeneity. Two genetic loci for DSAP were identified, but no specific genes were reported to date. The pathogenic mechanism of this disorder remains to be elucidated. In this study, a large, five-generation Chinese family with DSAP was genetically characterized. Two known DSAP loci, DSAP1 and DSAP2, two DSAP candidate genes (SART3 and SSH1), one DSP-linked locus and one PPPD-linked locus were first excluded in the family. The family was then characterized by genome-wide linkage analysis and a new DSAP locus was identified on chromosome 1p31.3-p31.1 with a maximum two-point LOD score of 5.09 with marker D1S2897 (theta = 0). Fine mapping showed that the disease gene was located within an 8.2 cM or 11.9 Mb region between markers D1S438 and D1S464. This is the third locus identified for DSAP (DSAP3). Eight candidate genes including GNG12, IL12RB2, ITGB3BP, DNAJ6, PIN1L, GADD45A, RPE65 and NEGR1 were sequenced, but found to be negative for functional sequence variants. Further mutational analysis of the candidate genes in the region will identify the specific gene for DSAP, which will provide insights into the pathogenesis of DSAP.

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Section: Discussionmentioning

confidence: 99%

Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3–p31.1

et al. 2008

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“…In approximately 7∼11.6% of patients, however, porokeratosis is associated with malignancies such as squamous cell carcinoma, basal cell carcinoma, and Bowen's disease. In particular, linear porokeratosis and porokeratosis of Mibelli are highly associated with these malignancies 11 . Therefore, in immunocompromised patients who develop porokeratosis, the possibility of malignant transformation must be considered, and such cases must be followed by close observation.…”

Section: Discussionmentioning

confidence: 99%

Atypical Porokeratosis Developing Following Bone Marrow Transplantation in a Patient with Myelodysplastic Syndrome

et al. 2010

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“…21 For this reason, porokeratosis should be considered a potentially premalignant lesion, prompting early treatment and /or close clinical surveillance for malignant change. 21 For this reason, porokeratosis should be considered a potentially premalignant lesion, prompting early treatment and /or close clinical surveillance for malignant change.…”

Section: Discussionmentioning

confidence: 99%

Porokeratosis of Mibelli following bone marrow transplantation

Alexis¹,

Busam²,

Myskowski³

2004

Int J Dermatol

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Background Porokeratosis is a rare disorder of keratinization with both autosomal dominant and acquired forms. Immunosuppression has been associated with the development of porokeratosis in numerous case reports and series. To our knowledge, however, only five cases of porokeratosis have been reported following bone marrow transplantation. Results We report five cases of porokeratosis of Mibelli following bone marrow transplantation. The diagnosis of porokeratosis was made between 1 and 13 years post‐transplantation. The underlying malignancy in four of the five cases was leukemia, while the fifth patient had non‐Hodgkin's lymphoma. Porokeratosis developed during remission in the four leukemia patients, whereas, in the fifth patient, it occurred during a relapse of lymphoma. Conclusions Porokeratosis may develop following bone marrow transplantation. Our five cases double the number reported in the medical literature, and the incidence of porokeratosis following bone marrow transplantation may be significantly higher than previously recognized. As cutaneous carcinomas have been reported in association with porokeratosis, careful surveillance for porokeratosis in bone marrow transplant recipients is warranted.

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Squamous Cell Carcinoma in a Renal Transplant Recipient with Linear Porokeratosis

Cited by 28 publications

References 11 publications

Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3–p31.1

Identification of a genetic locus for autosomal dominant disseminated superficial actinic porokeratosis on chromosome 1p31.3–p31.1

Atypical Porokeratosis Developing Following Bone Marrow Transplantation in a Patient with Myelodysplastic Syndrome

Porokeratosis of Mibelli following bone marrow transplantation

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