Squamous Cell Carcinoma in Chronic Ulcer in Lepromatous Leprosy

Yarak, Samira; Sérgio, Hirata; Michalany, Nílceo Schwery; Almeida, Fernando Augusto de; Jane, Tomimori Yamashita

doi:10.1111/j.1524-4725.2009.01328.x

Cited by 7 publications

(11 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was in keeping with our patients as all with welldifferentiated lesions presented with poor outcomes. However, some authors reported that treatment depended on the stage of the disease and the degree of cell differentiation [20]. Wide local excision in some selected cases with limited disease and amputation in the extremeties with locally advanced and infiltrating lesions extending to the bone as was our experience.…”

Section: Discussionsupporting

confidence: 50%

Marjolin’s Ulcer: Mismanaged Chronic Cutaneous Ulcers

Me¹

2014

J Clin Exp Dermatol Res

View full text Add to dashboard Cite

Background: In developing countries, chronic cutaneous ulcers, scars, and osteomyelitic sinuses are common lesions. Marjolin's ulcer is a malignant tumour that may arise from any of the above lesions. It may be misdiagnosed for infection and mismanaged as such. Method: We evaluated the clinical histories, treatment, and outcomes of patients who presented to the University of Calabar Teaching Hospital, Calabar with histologic diagnosis of Marjolin's ulcer from January 2010 to December 2012. Results: The seven patients were 4 males and 3 females whose ages ranged from 28-70 years (mean 45.7 years). Trauma was the leading cause of injury resulting in ulceration [road traffic injuries-4(57%), burns-2(29%)] while the other patient suffered diabetic foot ulcer. All the injuries involved the limbs [upper-1(14%), lower-6(86%)]. The histologic diagnosis in all the patients was squamous cell carcinoma with a mean latency period of 16.3 years. Late presentation with advanced loco-regional disease precluded curative surgery with poor outcomes. Conclusion: Marjolin's ulcer is preventable and areas of intervention have been highlighted. Educations concerning prevention, risk of chronic ulceration, early presentation, prompt and proper treatment is advocated for improved outcome.

show abstract

Section: Discussionsupporting

confidence: 50%

Marjolin’s Ulcer: Mismanaged Chronic Cutaneous Ulcers

Me¹

2014

J Clin Exp Dermatol Res

View full text Add to dashboard Cite

show abstract

“…In moderately or poorly differentiated lesions or well-differentiated large and invasive ulcers, broad surgical excision is recommended, and if it is localized on an extremity, amputation may be required. [10] Since SCC is the most common lesion to develop after Marjolin's ulcer, the lymph nodes and distant organs should be assessed for metastasis.…”

Section: Discussionmentioning

confidence: 99%

From Basic Chronic Wounds To Mortal Endings; Squamous Cell Carsinom Arising From Hidradenitis Suppurativa and Pilonidal Sinus Diseases

Öz¹

2018

South Clin Ist Euras

View full text Add to dashboard Cite

Marjolin's ulcer is an aggressive ulcerating malignancy that arises in a chronic wound and most often takes the form of squamous cell carcinoma (SCC). It often occurs in old burn scars, but it may also develop in post-traumatic lesions or chronic wounds. The prognosis is often poor as a result of delayed diagnosis. Presently described are cases in which chronic hidradenitis suppurativa and pilonidal sinus developed into SCC.

show abstract

“…Les facteurs favorisant la transformation maligne des ulcères trophiques au cours de la lèpre sont multiples et variés : longue durée de l'ulcère, irritation et traumatisme permanents, infection chronique avec ou sans ostéite, mauvaise hygiène, facteurs environnementaux et facteurs géné-tiques [3,8,9]. Le traitement des carcinomes sur MPP d'origine lépreuse n'est pas codifié, mais la plupart des auteurs s'accordent pour dire que le traitement de choix sur le plan carcinologique serait l'amputation du tiers moyen de la jambe associée à un curage ganglionnaire systématique [1,3,8].…”

Section: Discussionunclassified

“…Le traitement des carcinomes sur MPP d'origine lépreuse n'est pas codifié, mais la plupart des auteurs s'accordent pour dire que le traitement de choix sur le plan carcinologique serait l'amputation du tiers moyen de la jambe associée à un curage ganglionnaire systématique [1,3,8]. D'autres attitudes peuvent être proposées en fonction du type histologique, de l'atteinte osseuse et/ou musculaire sous-jacente et de la présence ou non d'adénopathies palpables cliniquement ; il s'agit d'amputations plus conservatrices de l'avant-pied, associées ou non à une radiothérapie sur les aires ganglionnaires [9]. La chimiothérapie est utilisée seulement au stade métastatique.…”

Section: Discussionunclassified

Dégénérescence carcinomateuse des maux perforants plantaires d’origine lépreuse: expérience du Centre national de léprologie de Casablanca

Hali

Latifi²,

Sbai³

2010

Bull. Soc. Pathol. Exot.

View full text Add to dashboard Cite

Malignant degeneration is a late complication of plantar ulcers in leprosy. The objective of this study is to describe and analyze the epidemiological, clinical, and therapeutic aspects of this complication in Morocco. A retrospective study was conducted from January 2000 to December 2009 at the National Center of Leprosy (CNL) in Casablanca. All our patients had a histological confirmation. Ten patients were included in this study. There were seven men and three women, with a mean age of 58.8 years. Six patients had a multibacillary form of leprosy and four had a paucibacillary form. The average duration of the plantar ulcers was 34.4 years. Clinical appearance at diagnosis was an ulcerative and vegetative tumor. Treatment was by radical amputation. Evolution was marked by metastatic spread in six patients. One patient died of disseminated disease. In Morocco, leprosy has been on the decline since 1990, but the occurrence of late complications in the leprosy patient as carcinoma of plantar ulcers persists. Prevention of these complications should be part of the national fight against leprosy.

show abstract

Squamous Cell Carcinoma in Chronic Ulcer in Lepromatous Leprosy

Cited by 7 publications

References 23 publications

Marjolin’s Ulcer: Mismanaged Chronic Cutaneous Ulcers

Marjolin’s Ulcer: Mismanaged Chronic Cutaneous Ulcers

From Basic Chronic Wounds To Mortal Endings; Squamous Cell Carsinom Arising From Hidradenitis Suppurativa and Pilonidal Sinus Diseases

Dégénérescence carcinomateuse des maux perforants plantaires d’origine lépreuse: expérience du Centre national de léprologie de Casablanca

Contact Info

Product

Resources

About