Squamous cell carcinoma in mature cystic teratoma ovary: A rare case report

Abstract

Mature cystic teratoma is the most common benign ovarian tumour accounting for 20% cases among all ovarian neoplasm. It is a germ cell tumour. Malignant transformation of an epithelial component to squamous cell carcinoma is very rare phenomena accounting for only 2% of squamous cell carcinoma cases. In this case report, we are presenting two cases of squamous cell carcinoma arising in the mature cystic teratoma.Two women of age 62 and 47 years were presented to the gynaecology OPD with the complaints of distension and pain in the lower abdomen. On CECT abdomen of both the cases, there were solid cystic mass seen and the possibility of teratoma was suggested. On histopathologic examination, diagnosis of a mature cystic teratoma with a component of squamous cell carcinoma was offered.Mature cystic teratoma is frequently seen in young women. Malignant transformation in the setting of mature cystic teratoma is rare event and is more common among postmenopausal women. Malignant transformation in mature cystic teratoma carries a poor prognosis and need to be treated aggressively. Early diagnosis and adjuvant chemotherapy is the only way to increase the chances of survival of the patient. Mature cystic teratoma, especially if it is presenting in post-menopausal women is alarming and should be viewed with a high degree of suspicion as there are more chances of malignant transformation.