Squamous Cell Carcinoma of Kidney and Its Prognosis: A Case Report and Review of the Literature

Abstract

Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.

Squamous cell carcinoma of the renal parenchyma presenting as hydronephrosis: a case report and review of the recent literature

“…One of the most consistent initial diagnoses is a neoplasm with unknown character. Primary SCC of the kidney should further rule out metastatic SCC with the combination of clinical history, imaging studies, and histopathology [7,10]. Nevertheless, it is difficult to make a definite diagnosis prior to surgery considering the nonspecific features of this case.…”

“…No less than 15 literature references have reported SCC of the renal pelvis in the recent 5 years, and a current review of the literature could identify only 5 literature references concerning SCC of the renal parenchyma [2][3][4][5][6][7] (Table 1). Until recently, SCC of the renal pelvis was regarded as urothelium metaplasia [7][8][9], however, the histological origin and mechanism of renal parenchyma SCC remains unknown. It probably originates from convoluted tubules or undifferentiated stem cells of the renal mesenchyme.…”

Primary Renal Squamous Cell Carcinoma: An Unusual Malignancy

“…Metastasis from other sites should be carefully ruled out before labeling it as primary renal SCC and despite rest of the findings there should be normal histopathology of the renal pelvis. 9 As compared to other malignancies of the upper urinary tract, SCC is more aggressive presenting as a high grade tumor with a poor prognosis. 10 Similar to other organs, conditions like inflammation, chronic irritation and infection are thought to develop squamous metaplasia in the urothelium present in the renal collecting system and this may further progress to dysplasia or even carcinoma in some patients.…”

Renal squamous cell carcinoma mimicking xanthogranulomatous pyelonephritis: Case report and review of literature

“…It is usually centered in the renal pelvis and secondarily invades the renal sinus fat and renal parenchyma [2] . Renal SCC is aggressive and high grade and usually advanced at the time of presentation, resulting in poor prognosis [5] .…”