Squamous cell carcinoma of lung with osteo-cartilaginous metaplasia &amp;#8211; a case report and review of the literature

Makhdoomi, Rumana; Baba, Khalil; Malik, R; Malik, Suhail; Rasool, Mohsin; Mubeen, Basharat

doi:10.5146/tjpath.2013.01177

Cited by 2 publications

(2 citation statements)

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“…Aberrant ossification has been reported in other lesions associated with physiological or nonphysiological keratins: seborrheic keratosis, [10] actinic keratosis, [11] keratoacanthoma, [12] acne vulgaris, [13] epidermal cyst, [14] trichilemmal cyst, [15] desmoplastic trichoepithelioma, [16] chondroid syringoma, [17] and tumors histopathologically exhibiting shadow cells such as craniopharyngioma [18] and calcifying odontogenic cyst. [19] This phenomenon has also been observed in keratinexpressing tumors, including thymoma, [20] sarcoma, [21] and carcinomas such as basal cell carcinoma, [22] squamous cell carcinoma, [23] papillary thyroid carcinoma, [24] and rectal carcinoma. [25] Some of these lesions involve foreign body reactions, while others have the potential for reactions, although not reported in the literature.…”

Section: Discussionmentioning

confidence: 92%

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

et al. 2022

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Rationale:Pilomatricoma is a benign skin appendageal tumor derived from hair follicle matrix cells that commonly affects the head, neck, and upper extremities of the pediatric population. Since the original tumor description, diverse variants have been reported in the literature. Pilomatricoma with florid osseous metaplasia is described as an ossifying pilomatricoma and is recognized as a distinct variant of this benign tumor. However, the pathogenesis of this variant remains unclear. In this study, we present an uncommon case of ossifying pilomatricoma and address the pathogenesis of metaplastic ossification through a comprehensive literature review.Patient concerns:A 14-year-old boy presented with an asymptomatic protuberant mass in the preauricular region.Diagnosis:Based on its clinicopathological features, we diagnosed the lesion as an ossifying pilomatricoma.Interventions and outcomes:The lesion was surgically removed under local anesthesia. The postoperative course was uneventful during the 6-month postoperative follow-up.Lessons:We suggest that metaplastic ossification in ossifying pilomatricoma represents another feature of foreign body reaction to keratinous materials containing shadow cells in old lesions and a walling-off phenomenon to prevent exposure of surrounding tissues to keratinous materials.

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Section: Discussionmentioning

confidence: 92%

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

et al. 2022

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“…The distribution of seed genes and crucial nodes in significant terms showed related biological processes such as regulation of fatty acid oxidation (GO: 0046320) and regulation of fatty acid biosynthetic process (GO: 0042304) (Supplementary file) accompanied by dominant GO terms such as response to hyperxia (GO: 0055093) and response to increased oxygen level (GO: 0036296) in adenocarcinoma. Accordingly with these results there are number of studies about association between lung cancer cells survival under different levels of oxygen and fatty acid oxidation (74) also fatty acid oxidation process as a promising therapeutic target in cancer (75). Consequently considering these term we can imply the important role of fatty acid metabolism in lung adenocarcinoma.…”

Section: Discussionmentioning

confidence: 99%

Identification of key regulators in non-small cell lung cancer based on network topology and modularity analysis

Izadi¹

2016

Arvand Journal of Health and Medical Sciences

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Lung cancer predominantly non-small cell lung cancer is a worldwide leading cause of tumor killer therefore exploring underlying biological networks and modularity analysis will be possibly lead to identifying putative key genes involved in this malignancy and its sub-types. In this study using GENIE3 one of the most prominent gene regulatory network inference algorithms we reconstructed independent gene regulatory networks from normal and lung cancer data following topology analysis. Afterward we attempted to highlight the crucial genes involved in adenocarcinoma and squamous sub-types of this cancer by networks modularity analysis. The results lead to detection of 19 critical genes as varied hub and bottleneck genes and further seed and crucial nodes by analysis of extracted sub-networks from first neighborhoods of hubs and bottlenecks. As a result we observed that the detected genes involved in several of biological process toward lung cancer progression. Analysis of non-small cell transcriptional networks showed a potential ability to provide useful information toward gaining more insights in this cancer also its sub-types.

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Squamous cell carcinoma of lung with osteo-cartilaginous metaplasia – a case report and review of the literature

Cited by 2 publications

References 6 publications

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

Ossifying pilomatricoma and a novel hypothesis for its pathogenesis

Identification of key regulators in non-small cell lung cancer based on network topology and modularity analysis

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