Squamous Cell Carcinoma of Rectum: How to Treat?

Sundriyal, Deepak; Shirsi, Nikhil; Kotwal, Sumedha; Dawar, Ramesh

doi:10.1007/s13193-015-0434-8

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…So far, while different theories have been proposed, the etiology of rectal SCC is still debated ( 1 , 2 ). It has been suggested that rectal SCC could originate from pluripotent stem cells that could differentiate into different lineages ( 6 ). Other groups suggested a potential malignant evolution from persistent ectopic embryonal nests of ectodermal cells ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson

Ciardiello,

Del Tufo,

Parente

et al. 2023

Front. Oncol.

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Synchronous tumors of the rectum and anus are sporadic. Most cases in the literature are rectal adenocarcinomas with concomitant anal squamous cell carcinoma. To date, only two cases of concomitant squamous cell carcinomas of the rectum and anus are reported, and both were treated with up-front surgery and received abdominoperineal resection with colostomy. Here, we report the first case in the literature of a patient with synchronous HPV-positive squamous cell carcinoma of the rectum and anus treated with definitive chemoradiotherapy with curative intent. The clinical-radiological evaluation demonstrated complete tumor regression. After 2 years of follow-up, no evidence of recurrence was observed.

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Section: Discussionmentioning

confidence: 99%

Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson

Ciardiello,

Del Tufo,

Parente

et al. 2023

Front. Oncol.

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“…However, several associations have been observed. Some cases reports have been found SCC in association with inflammatory bowel diseases involving colon and rectum, ulcerative colitis (8) , infections including Schisotomiasis and Entamoeba Histolitica (8) , previous radiation exposure to the pelvis (9) and immunosuppressive state (10) . Although a clear association betwen SCC of anal canal and Human Papilloma Virus (HPV) exists, similar relation with rectal SCC has not been etablished.…”

Section: Discussionmentioning

confidence: 99%

Primary Squamous Cell Carcinoma of the Rectum Case Report with Literature Review

Abbassi

Touil²,

Echchikhi³

et al. 2017

IAM

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Background: Squamous cell carcinoma of the rectum is a distinct entity. We report a rare case of squamous cell carcinoma of the middle and low rectum. Case presentation: The patient was a 60-year-old man who presented with a history of rectal Bleeding, constipation and pelvic painless. Rectoscopy and Colonoscopy revealed a polypoid tumour of the middle and low rectum. Biopsies of this mass revealed a poorly differentiated squamous cell carcinoma of the rectum. Pelvic Magnetic Resonance Imaging scan showed a polypoid, irregular and circumferential tumor in the middle and low rectum extending in length on 95mm. CT scan of the chest, abdomen and pelvis was negative for distal metastases. The patient received combined chemo-radiation. Overall treatment time was 45 days. After 6 weeks of the end of treatment, the revaluation clinical tests by pelvic magnetic resonnance imaging showed a poor response. After 3 months, Positron Emission Tomography with Fluorodeoxyglucose demonstrated a little hypermetabolic area with maximum standard up take value of 6,7 in the low rectum. Patient underwent a surgical resection. The postoperative histopathological findings were non specific and chronic inflammatory changes. At the time this report was written, the patient had 18 months of follow-up. No evidence of malignacy is found. Conclusion: Squamous cell carcinoma of the rectum is a distinct entity. Chemoradiation should be chosen as the first-line therapy for suqamous cell carcinoma of the rectum. However,a large study will be required to establish a safe and effective regimen.

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“…Radiotherapy should target the tumour, mesorectum, presacral nodes and internal iliac nodal basins. 39 Similar to aSCC treatment guidelines, most case reports and series of rSCC have used 5-FU associated with MMC or cisplatin 44 , 45 , 46 , 47 as the CRT regimen ( Table 3 ) with encouraging outcomes (most patients alive with no evidence of disease in a long follow-up).…”

Section: Treatment Optionsmentioning

confidence: 99%

Squamous rectal carcinoma: a rare malignancy, literature review and management recommendations

2021

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Squamous cell carcinoma of the rectum is a rare malignancy (0.3% of all rectal cancers), with no known risk factor. These tumours are assessed as rectal cancer using immunohistochemical and radiological tests, and certain criteria (localisation, relationship with neighbouring structures) have to be fulfilled to make the diagnosis. Some clinicians used to stage them with the anal cancer TNM (tumourenodeemetastasis), whereas others used the rectal cancer TNM. When localised, the tendency nowadays is to treat those tumours like squamous anal cancers with definitive chemoradiotherapy (5-fluorouracil and mitomycin) and to skip surgery. For metastatic disease there is no clearly validated regimen and treatment should be based on recommendations of squamous anal cancers because of their common histology. Concerning follow-up after a curative approach, techniques should follow those for anal cancer as well, evaluating a delayed response.

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Squamous Cell Carcinoma of Rectum: How to Treat?

Cited by 4 publications

References 12 publications

Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson

Case report of unusual synchronous anal and rectal squamous cell carcinoma: clinical and therapeutic lesson

Primary Squamous Cell Carcinoma of the Rectum Case Report with Literature Review

Squamous rectal carcinoma: a rare malignancy, literature review and management recommendations

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