Squamous Cell Carcinoma of Skin Cancer Margin Classification From Digital Histopathology Images Using Deep Learning

Abstract

Objectives Now a days, squamous cell carcinoma (SCC) margin assessment is done by examining histopathology images and inspection of whole slide images (WSI) using a conventional microscope. This is time-consuming, tedious, and depends on experts’ experience which may lead to misdiagnosis and mistreatment plans. This study aims to develop a system for the automatic diagnosis of skin cancer margin for squamous cell carcinoma from histopathology microscopic images by applying deep learning techniques. Methods The system was trained, validated, and tested using histopathology images of SCC cancer locally acquired from Jimma Medical Center Pathology Department from seven different skin sites using an Olympus digital microscope. All images were preprocessed and trained with transfer learning pre-trained models by fine-tuning the hyper-parameter of the selected models. Results The overall best training accuracy of the models become 95.3%, 97.1%, 89.8%, and 89.9% on EffecientNetB0, MobileNetv2, ResNet50, VGG16 respectively. In addition to this, the best validation accuracy of the models was 94.7%, 91.8%, 87.8%, and 86.7% respectively. The best testing accuracy of the models at the same epoch was 95.2%, 91.5%, 87%, and 85.5% respectively. From these models, EfficientNetB0 showed the best average training and testing accuracy than the other models. Conclusions The system assists the pathologist during the margin assessment of SCC by decreasing the diagnosis time from an average of 25 minutes to less than a minute.

Investigation of the Ability of Crocin to Treat Skin Cancer Chemically Induced in Mice via the Inhibition of the Wnt/β-Catenin and Fibrotic Pathway

“…Skin cancer is defined as an irregular enlargement and proliferation of skin cells. It is caused by a cancerous overgrowth of abnormal cells in the basal layer of the epidermis [ 1 ]. Skin cancer is a major health problem with increased incidence in all age groups in recent years.…”