Squamous Cell Carcinoma of the Lower Lip Arising in Discoid Lupus Lesion - A Case Report

Abstract

IntroductionRare examples from the literature report a possible degeneration of mucosal lesions of L.E.C. We report a case of squamous cell carcinoma grafted on a lesion of the lower lip in a patient followed for L.E.C. at the ENT and Maxillo-facial department of Mohamed VI University Hospital of Oujda. Case reportA 47-year-old man, with a notion of photosensitivity, presents an atrophic erythematous-violet plaques in the photo-exposed zones evolving for 20 years, evoking chronic discoid lupus cutaneous without any clinical, biological or radiological sign of systematization. The patient had a painful lower ulcer-budding process that had been evolving for 2 years, with suspected bilateral cervical lymphadenopathy. The biopsy revealed a well-differentiated infiltrating squamous cell carcinoma. A surgical excision oncology is then performed with a labial plasty and an obviously bilateral lymph node. ConclusionThe risk of degeneration of skin lesions of lupus discoid is minimal and rare, although monitoring of lupus scars remains essential, especially in the context where exposure to ultraviolet radiation is added as a predisposing factor for possible malignant transformation, surgical treatment is required at the appearance of suspicious lesions confirmed histologically.

Squamous Cell Carcinoma Complicating Plaque of Lupus Erythematosus - A Case Series

“…Long term follow up for such patients is warranted as there are high chances of recurrences [9]. The interval between development of DLE and SCC has varied from 4 to 20 years [10].…”

The Spectrum of Cutaneous Manifestations in Lupus Erythematosus: A Comprehensive Review

“…They are usually symptomless but seldom may cause mild hypersensitivity and dryness of the oral cavity [18,126]. Furthermore, the available literature includes numerous case reports of squamous cell carcinoma development within mucosal lupus lesions, especially in the red zone of the lips [127][128][129][130][131][132][133][134].…”

“…numerous case reports of squamous cell carcinoma development within mucos lesions, especially in the red zone of the lips [127][128][129][130][131][132][133][134]. For instance, mucous membranes may be affected in DLE, and in cases of th mucosa involvement, it may resemble lichen planus (LP) and oral leukoplakia main distinguishing features are the radial arrangement and brush-like distribut central erythema [84].…”