Squamous cell carcinoma of the larynx in a Pekingese dog

Nazifi, Saeed; Tamadon, Amin; Parizi, Abdol Hamid Meimandi; Mahjoor, A.A.; Bigham, A. S.

doi:10.1007/s00580-006-0625-3

Cited by 2 publications

(4 citation statements)

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“…In most cases it develops in tonsils, stomach, and urinary bladder (38). Cases of squamous cell carcinoma in the larynx were described in dogs, cats, horses, and the black bear (16,26,35). The syndrome of non-specific signs, such as coughing, aphonia, lack of appetite, or apathy, frequently bypassing the accessory studies during the diagnostic process, cause difficulties in establishing the correct diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Primary laryngeal tumours seldom develop in companion animals, and if they do, they usually affect older animals or animals of a moderate age (24,26). Most frequently they are observed in dogs and cats (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…In animals, the studies are continued on correlation between inhalation of tobacco smoke and development of tumours in respiratory pathways (7,24). The larynx may be affected by both benign and malignant tumours; in dogs development of squamous cell carcinoma is detected most frequently, while cats are mostly affected by lymphomas (5,24,26,32). Individual categories of laryngeal tumours developing in animals are listed in Table 1 (24).…”

Section: Introductionmentioning

confidence: 99%

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Expression of p16 (INK4a), cytokeratin 19, and Ki-67 in canine laryngeal squamous cell carcinoma

Kandefer-Gola

Ciaputa

Nowak

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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The study aimed at morphological and immunohistochemical characteristics of laryngeal squamous cell carcinomas and their metastases in canine lymph nodes and lungs. Tissue sections were stained using classical technique with haematoxylin and eosin. In addition, immunohistochemical studies were performed with p16, cytokeratin, and Ki-67 antibodies. An expression of all examined antigens was detected in laryngeal tumours, while in tumour metastases only expression of p16 protein and cytokeratin was demonstrated. The results pointed to higher proliferative potential of the primary tumour than of their metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of p16 (INK4a), cytokeratin 19, and Ki-67 in canine laryngeal squamous cell carcinoma

Kandefer-Gola

Ciaputa

Nowak

et al. 2013

Bulletin of the Veterinary Institute in Pulawy

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“…Laryngeal paralysis is a well described condition in dogs and represents the most common form of laryngeal disease (MacPhail 2017). Neoplasms involving the larynx in dogs have been described infrequently and include squamous cell carcinoma (Nazifi et al 2006), extramedullary plasmacytoma (Witham et al 2012), mast cell tumour (Beaumont et al 1979), rhabdomyosarcoma (Sanspoux 2016), chondrosarcoma (Shoieb 2014), melanoma and myxochondroma (Ramírez et al 2015). In contrast, non-neoplastic lesions are poorly characterised with inflammatory laryngeal diseases mentioned in a textbook (MacPhail 2017) and reports on granulomas (granulation tissue) associated with chronic intubation (Neilson & Pinelas 2016), brachycephalic obstructive airway syndrome (Sarran et al 2018) and secondary to Leishmania (Torrent et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Infiltrative laryngeal disease in dogs

Dixon

Tivers²,

Packham

et al. 2020

J of Small Animal Practice

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Objectives To describe the clinical features and outcome of neoplastic and inflammatory infiltrative laryngeal disease in dogs. Materials and Methods Medical records at a single referral centre were retrospectively reviewed for dogs diagnosed with infiltrative laryngeal disease by CT or laryngoscopy. Results Fifteen dogs were included, with a median age of 6 years (range 1‐14 years). Thirteen dogs were diagnosed with inflammatory disease including granulation tissue (n = 4) and neutrophilic (n = 2), septic neutrophilic (n = 2), eosinophilic (n = 1) lymphocytic/plasmacytic (n = 1) and mixed/unclassified (n = 3) inflammation. One dog was diagnosed with large cell lymphoma and one dog was diagnosed with mast cell tumour. Twelve dogs survived to discharge. Follow‐up was available for 10 dogs diagnosed with inflammatory disease. Four had fully recovered (7, 10, 23 and 32 months) and one dog developed acute leukaemia and was euthanased at 2 months. Five dogs had recurrence of clinical signs at 1, 1, 5, 17 and 26 months. The dog with lymphoma was euthanased at 8 months and the dog with mast cell tumour died at 5 months. Clinical Significance In this cohort, infiltrative inflammatory lesions of the larynx were more common than neoplastic infiltration. For dogs that survived to discharge, outcome was fair although relapse was common.

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Squamous cell carcinoma of the larynx in a Pekingese dog

Cited by 2 publications

References 4 publications

Expression of p16 (INK4a), cytokeratin 19, and Ki-67 in canine laryngeal squamous cell carcinoma

Expression of p16 (INK4a), cytokeratin 19, and Ki-67 in canine laryngeal squamous cell carcinoma

Infiltrative laryngeal disease in dogs

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