Squamous Cell Carcinoma of the Upper Aerodigestive Tract

Landry, David; Glastonbury, Christine M.

doi:10.1016/j.rcl.2014.09.013

Cited by 29 publications

(24 citation statements)

References 34 publications

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“…Due to the rich lymphatics of the supraglottis, patients often present with advanced disease characterized by bilateral cervical lymphadenopathy at presentation. Attributable to minimal symptomatology in the early stages, supraglottic SCCa most often presents late . When more advanced, supraglottic tumors may present with a variety of symptoms related to their spread and advanced stage due to infiltration and metastasis to lymph nodes .…”

Section: Discussionmentioning

confidence: 99%

Supraglottic Squamous Cell Carcinoma: A Population‐Based Study of 22,675 Cases

Patel¹,

Echanique²,

Yip³

et al. 2018

The Laryngoscope

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Objectives/Hypothesis The authors used the Surveillance, Epidemiology, and End Results (SEER) database to analyze epidemiological features of patients presenting with supraglottic squamous cell carcinoma (SCCa) and to evaluate treatment trends and outcomes. Methods The SEER database was queried for patients with supraglottic SCCa from 1973 to 2013. Information on demographics; tumor size; histologic grade; American Joint Committee on Cancer (AJCC) stage; SEER local, regional, distant stage; and treatment modality were analyzed. Results There were 22,675 cases of primary supraglottic SCCa identified. The mean age at diagnosis was 62.3 years, with males accounting for 70.3% of all cases. A high percentage of patients presented with stage IV disease (44.9%). The most common treatment modality was radiotherapy (46.6%), followed by combination of surgery and radiotherapy (29.2%) and surgery alone (15.0%). Overall 5‐year disease‐specific survival (DSS) for all cases was 54.0%. When stratified by treatment modality, 5‐year DSS was best for patients receiving surgery alone (64.2%). However, for patients with AJCC stage IV disease, survival was significantly better with combined surgery and radiotherapy (52.5%). Conclusion In general, supraglottic SCCa is treated most commonly with radiotherapy, followed by surgery and radiotherapy. Patients managed surgically had better 5‐year DSS when compared to patients treated by other modalities. However, when stratified by stage, patients with AJCC stage IV disease had significantly better survival with combined surgery and radiotherapy. Of patients receiving surgery, supraglottic laryngectomy was found to have a significantly better 5‐year DSS when compared to both total laryngectomy and laryngectomy, not otherwise specified. Level of Evidence NA Laryngoscope, 129:1822–1827, 2019

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Section: Discussionmentioning

confidence: 99%

Supraglottic Squamous Cell Carcinoma: A Population‐Based Study of 22,675 Cases

Patel¹,

Echanique²,

Yip³

et al. 2018

The Laryngoscope

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“…The pre-epiglottic fat spaces are typically preserved, in contradistinction to laryngeal carcinoma, which tends to infiltrate the pre-epiglottic fat and can involve nearly any laryngeal structure including the epiglottis, aryepiglottic folds, and true and false vocal cords. 11,27,32 Also differentiating tuberculosis from carcinoma, the most common symptom of tuberculosis is hoarseness, with odynophagia present in 45%-90% of patients. Laryngeal carcinoma, on the other hand, more often presents with a foreign body sensation and referred otalgia.…”

Section: Discussionmentioning

confidence: 99%

“…Although benignappearing, the patient's tobacco history risk factor was sufficient to warrant a CT scan to exclude deeper involvement of possible malignancy, as up to 95% of patients with laryngeal cancer have a history of tobacco use. 11 CT did not show any malignant features, and the patient thereafter underwent excisional biopsy of the lesion at its base of attachment using a CO 2 laser, with pathologic examination revealing a benign squamous papilloma. At the time of surgery, the lesion appeared superficial without apparent involvement of the underlying cartilage ( Figure 1).…”

Section: Case Reportmentioning

confidence: 97%

Epiglottic masses identified on CT imaging: A case report and review of the broad differential diagnosis

et al. 2015

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Epiglottic masses may be cystic, granulomatous, infectious, benign or malignant neoplastic, or manifestations of a systemic disease. When large in size, the airway may become obstructed, and when accompanied by suspicious features such as cartilaginous invasion, extension to the pre-epiglottic or para-glottic spaces, or lymphadenopathy, the radiologist must consider malignancy as a primary differential diagnosis. However, when only benign features are identified, the differential diagnosis is broad. We present a 65-year-old female with an incidental 1 cm exophytic, pedunculated, papillomatous lesion on the laryngeal surface of the epiglottis discovered upon endoscopic evaluation for dyspepsia and heartburn. Because of her risk factors for malignancy, CT scan was requested and revealed only benign features. Subsequent excisional biopsy revealed a benign squamous papilloma; however, multiple additional differential considerations were entertained preoperatively.

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“…In der Onkologie des Kopf-Hals-Bereichs ist die Bildgebung ein wichtiger Bestandteil zur Diagnostik und Therapieplanung maligner Tumoren [1][2][3]. Allein die klinische Untersuchung erlaubt in vielen Fäl-len keine exakte Einschätzung der Ausdehnung eines Tumors, sondern spiegelt lediglich die Oberflächenmanifesta-tion des Malignoms wider.…”

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Bootz

Greschus

2017

HNO

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Alongside clinical investigation, imaging is an important diagnostic modality for guiding treatment decisions and particularly for surgical planning in head and neck cancer. The significance and type of imaging depends on localization of the primary tumor. Beside the primary tumor, each imaging procedure must also include the lymph nodes, in order to develop an overall concept of surgical treatment. In addition to the superficial growth of a tumor, it is of utmost importance that its infiltration also be detected by imaging, in order to define the extent of tumor resection and identify potentially necessary reconstructive procedures. The type of imaging needed to understand tumor localization and size, e.g., CT or MRI, depends on the region. In some cases the methods are complementary.

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Squamous Cell Carcinoma of the Upper Aerodigestive Tract

Cited by 29 publications

References 34 publications

Supraglottic Squamous Cell Carcinoma: A Population‐Based Study of 22,675 Cases

Supraglottic Squamous Cell Carcinoma: A Population‐Based Study of 22,675 Cases

Epiglottic masses identified on CT imaging: A case report and review of the broad differential diagnosis

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