Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis

Guillou, Louis; Sahli, Roland; Chaubert, Pascal; Monnier, Philippe; Cuttat, J. F.; Costa, José

doi:10.1097/00000478-199109000-00010

Cited by 70 publications

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“…Polymerase chain reaction (PCR) typing performed at postmortem examination showed the presence of HPV 11 DNA in both the papillomas and squamous cell carcinoma. This is the fifth report of an association between HPV 11 and malignant transformation of pulmonary papillomas (3,4,6,7). Together, these five cases suggest a stereotypical clinical setting for the emergence of invasive carcinoma from RRP.…”

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confidence: 59%

“…Most patients require numerous excisions, frequently require tracheostomy, and ultimately die as a result of respiratory insufficiency or infections (2). Malignant transformation of laryngeal or pulmonary lesions is a very rare event in the absence of prior irradiation; fewer than 20 cases are reported in the English literature (3)(4)(5)(6). It remains unclear whether the risk of malignant transformation is dependent on the HPV serotype involved.…”

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confidence: 99%

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Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

et al. 2000

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Squamous papillomas of the lung are an uncommon feature of recurrent respiratory papillomatosis, occurring in fewer than 1% of cases. We describe a 23-year-old patient with pulmonary papillomas who developed a fatal squamous cell carcinoma of the lung. PCR-based human papillomavirus (HPV) typing showed the presence of HPV 11 DNA in both benign papillomas and invasive carcinoma. A review of the literature reveals four reports of malignant transformation of juvenile-onset recurrent respiratory papillomatosis in which HPV typing was performed. Similar clinical features are noted in all of the reports; specifically, each case has arisen in a young adult man with a history of papillomatosis since childhood. In each of the cases, HPV 11 was identified in association with the squamous cell carcinoma. Although HPV 11 is uncommonly associated with the development of invasive carcinoma at other sites, these findings suggest that it is correlated with malignant transformation in the setting of juvenile-onset recurrent respiratory papillomatosis. KEY WORDS: Human papillomavirus 11, Recurrent respiratory papillomatosis, Squamous cell carcinoma. Mod Pathol 2000;13(8):914-918Juvenile-onset recurrent respiratory papillomatosis (RRP) is characterized by numerous squamous papillomas of the respiratory tract secondary to infection with human papillomavirus (HPV) types 6 and 11 (1, 2). HPV is thought to be acquired at the time of vaginal delivery in the presence of genital lesions, and patients typically present with symptoms of hoarseness or respiratory obstruction in childhood or adolescence. In the majority of cases, the papillomas are confined to the larynx; only 5% of patients exhibit more distal involvement of the trachea, and involvement of lung parenchyma occurs in fewer than 1% of cases (1, 2). Pulmonary involvement by RRP is twice as frequent in males than in females and is associated with an aggressive clinical course. Most patients require numerous excisions, frequently require tracheostomy, and ultimately die as a result of respiratory insufficiency or infections (2). Malignant transformation of laryngeal or pulmonary lesions is a very rare event in the absence of prior irradiation; fewer than 20 cases are reported in the English literature (3-6). It remains unclear whether the risk of malignant transformation is dependent on the HPV serotype involved.We describe a patient with pulmonary involvement by RRP who developed a squamous cell carcinoma of the lung. Polymerase chain reaction (PCR) typing performed at postmortem examination showed the presence of HPV 11 DNA in both the papillomas and squamous cell carcinoma. This is the fifth report of an association between HPV 11 and malignant transformation of pulmonary papillomas (3, 4, 6, 7). Together, these five cases suggest a stereotypical clinical setting for the emergence of invasive carcinoma from RRP. CASE REPORTThe patient was a 23-year-old white man with a history of RRP, initially diagnosed at age 5. By age 10, he had developed laryngeal, tracheal, and pulmonary ...

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Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

et al. 2000

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“…Syrj/inen (1980) suggested a role for HPVs in the development of squamous cell carcinomas of the lung, based on histological data. Subsequently, HPV DNA was detected in several isolated cases of lung squamous cell carcinomas (Stremlau et aL, 1985;Byrne et al, 1987;Helmuth & Strate, 1987;Ostrow et al, 1987;Syrj~inen & Syrj/inen, 1987;Guillon et al, 1991;DiLorenzo et al, 1992;Popper et al, 1992;Yousem et al, 1992), although large numbers of biopsies have been screened (Stremlau et al, 1985;Ostrow et al, 1987;E.-M. de Villiers, unpublished results).…”

Section: Introductionmentioning

confidence: 99%

Development of a Broad Spectrum PCR Assay for Papillomaviruses and its Application in Screening Lung Cancer Biopsies

Shamanin

Delius

Villiers

1994

Journal of General Virology

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A PCR assay was developed to detect known and as yet unidentified papillomaviruses (PVs). For this purpose we analysed the conserved amino acid sequences in the L1 and E1 open reading frames of 45 human and nine animal PVs. Candidate regions for the design of a primer were identified as those having the least number of amino acid and nucleotide sequence variants among the different PVs. These regions in the L10RF have been described previously. We modified the sequences of the backward and the forward primers, as well as the sequence of the oligonucleotide used as the degenerate probe, in order to cover a broader spectrum of PVs. The sensitivity of the assay for the human and animal PVs tested after hybridization with a 32P-labelled degenerate oligonucleotide probe was one genome copy per cell for integrated PV DNA and 10 genome copies per cell for plasmid PV DNA. The only exceptions were human papillomavirus (HPV) type 4, HPV60 and HPV65, for which a lower sensitivity was obtained. This group could be detected only by using additional primers. The assay was used to analyse 85 lung cancer biopsies representing different histological types. Using this system no PV DNA sequences were detected in the biopsies when compared with human placental DNA (a negative control) and PV DNA-positive standards.

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“…HPV11 is present in 0.5% of samples from HPV-positive women with a normal cytology worldwide and causes 2.3% of cervical low-grade squamous cell intraepithelial lesions (12,13). However, rare case reports of HPV11-positive cases of cervical and anal squamous cell carcinomas, malignantly transformed laryngeal papillomas, and sinonasal inverted papillomas associated with squamous cell carcinoma can be found in the literature (14)(15)(16)(17)(18)(19)(20)(21). Due to its clinical significance, HPV11 has been included in the current quadrivalent and nonavalent prophylactic HPV vaccines (22,23).…”

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Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

Jelen

Chen

Kocjan

et al. 2016

J Virol

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Human papillomavirus 11 (HPV11) is an etiological agent of anogenital warts and laryngeal papillomas and is included in the 4-valent and 9-valent prophylactic HPV vaccines. We established the largest collection of globally circulating HPV11 isolates to date and examined the genomic diversity of 433 isolates and 78 complete genomes (CGs) from six continents. The genomic variation within the 2,800-bp E5a-E5b-L1-upstream regulatory region was initially studied in 181/207 (87.4%) HPV11 isolates collected for this study. Of these, the CGs of 30 HPV11 variants containing unique single nucleotide polymorphisms (SNPs), indels (insertions or deletions), or amino acid changes were fully sequenced. A maximum likelihood tree based on the global alignment of 78 HPV11 CGs (30 CGs from our study and 48 CGs from GenBank) revealed two HPV11 lineages (lineages A and B) and four sublineages (sublineages A1, A2, A3, and A4). HPV11 (sub)lineage-specific SNPs within the CG were identified, as well as the 208-bp representative region for CG-based phylogenetic clustering within the partial E2 open reading frame and noncoding region 2. Globally, sublineage A2 was the most prevalent, followed by sublineages A1, A3, and A4 and lineage B. IMPORTANCEThis collaborative international study defined the global heterogeneity of HPV11 and established the largest collection of globally circulating HPV11 genomic variants to date. Thirty novel complete HPV11 genomes were determined and submitted to the available sequence repositories. Global phylogenetic analysis revealed two HPV11 variant lineages and four sublineages. The HPV11 (sub)lineage-specific SNPs and the representative region identified within the partial genomic region E2/noncoding region 2 (NCR2) will enable the simpler identification and comparison of HPV11 variants worldwide. This study provides an important knowledge base for HPV11 for future studies in HPV epidemiology, evolution, pathogenicity, prevention, and molecular assay development. Human papillomavirus 11 (HPV11), which belongs to species 10 of the Alphapapillomavirus genus (Alpha-PV), is etiologically associated with approximately 20% of anogenital warts and 30 to 40% of laryngeal papillomas (1-11). HPV11 is generally considered a low-risk HPV type due to its rare presence in HPVrelated cancers in humans, especially cervical cancer (9). HPV11 is present in 0.5% of samples from HPV-positive women with a normal cytology worldwide and causes 2.3% of cervical low-grade squamous cell intraepithelial lesions (12, 13). However, rare case reports of HPV11-positive cases of cervical and anal squamous cell carcinomas, malignantly transformed laryngeal papillomas, and sinonasal inverted papillomas associated with squamous cell carcinoma can be found in the literature (14-21). Due to its clinical significance, HPV11 has been included in the current quadrivalent and nonavalent prophylactic HPV vaccines (22,23).The genetic diversity of HPV11 was studied for the first time in 1995, when Heinzel et al. sequenced the noncoding upstre...

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Squamous Cell Carcinoma of the Lung in a Nonsmoking, Nonirradiated Patient with Juvenile Laryngotracheal Papillomatosis

Cited by 70 publications

References 0 publications

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

Squamous Cell Carcinoma Arising in Recurrent Respiratory Papillomatosis with Pulmonary Involvement: Emerging Common Pattern of Clinical Features and Human Papillomavirus Serotype Association

Development of a Broad Spectrum PCR Assay for Papillomaviruses and its Application in Screening Lung Cancer Biopsies

Global Genomic Diversity of Human Papillomavirus 11 Based on 433 Isolates and 78 Complete Genome Sequences

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