Squamous cell carcinoma of the oral tongue in young patients: a matched-pair analysis

Lee, Ching‐Chih; Ho, Han‐Chen; Chen, Huang-Li; Hsiao, Shih-Hsuan; Hwang, Juen-Haur; Hung, Shih‐Kai

doi:10.1080/00016480701230910

Cited by 35 publications

(41 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Five of the 10 papers about the tumor-node-metastasis (TNM) Staging System indicated that a large amount of patients were diagnosed as T1 and/or T2 (8,(13)(14)(15)20) , being stages T3 and T4 (extensive tumors) predominant in other works (7,(10)(11)(12)18) .…”

Section: Resultsmentioning

confidence: 99%

“…As for sample size, the number of participants ranged from 10 to 2,223 young subjects, as described in Table 1. Age distribution of patients varied: individuals considered young were those aged 18-39 years (7,8,10,11) (23.5%), < 30 years (13,20) (3,6,8,9,(11)(12)(13)(14)(16)(17)(18)(19)(20)(21) ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…In six studies almost all the patients were treated with surgical resection only (8, 13-15, 20, 21) ; in the other four cases, surgery was chiefly combined with radiation therapy (7,(10)(11)(12) (Table 3). …”

Section: Resultsmentioning

confidence: 99%

“…Among the 16 studies that associated SCC to the oral cavity, seven used only lesions in the tongue (3,6,8,12,13,15,20) as inclusion criteria; nine included other locations, of which six identified the tongue as the site of highest incidence (7, 9-11, 14, 16) , and just two observed predominance on the floor of mouth (18,21) . Concerning the relationship with harmful habits, nine investigations demonstrated association between tobacco and/or alcohol use and OSCC, of which six presented positive association (7,10,11,16,18,19) .…”

Section: Resultsmentioning

confidence: 99%

“…The criterion N0 (absence of metastasis in regional lymph nodes) (7,8,(12)(13)(14)(18)(19)(20) prevailed in eight studies, and M0 (absence of distance metastasis) was described in all the 10 studies. On the subject of clinical stage, seven works reported that nearly all the patients were in stages III and IV (more advanced tumors) (3, 10-12, 16, 18, 20) , and two showed predominance of stages I and II (8,13) (Table 3).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Mesquita¹,

Cavalvanti

Nonaka

et al. 2014

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

The oral squamous cell carcinoma (OSCC) very often affects subjects above the sixth decade of life. However an increasing incidence has been observed in younger individuals, below 40 years. We conducted a systematized review of the current clinical, histopathological and therapeutic aspects of OSCC in young patients. Our work included studies that addressed OSCC involving young patients in the period 2007-2012, and which were indexed in PubMed. Initially, 499 articles were obtained; after refinement, 340 articles had their titles and abstracts evaluated, with 17 included in the sample. The majority of studies reported male predominance (87.5%), association with tobacco and/ or alcohol use (66.6%), advanced clinical stages at diagnosis (77.7%) and, at histopathology, moderately differentiated tumors (72.7%). Based on the results, we believe there are differences in the factors associated with pathogenesis, biological behavior and prognosis in young patients, since most studies show more rapid and aggressive tumor progression in this age group. We suggest the conduction of research focusing on the pathogenesis and carcinogenesis of OSCC in young patients, thereby searching for better scientific evidence.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Mesquita¹,

Cavalvanti

Nonaka

et al. 2014

J. Bras. Patol. Med. Lab.

View full text Add to dashboard Cite

show abstract

Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer

Tam

Araslanova

Low

et al. 2017

JAMA Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

et al. 2021

View full text Add to dashboard Cite

While evidence suggests an increasing incidence of tongue cancer in young adults, published findings regarding the prognostic role of age at diagnosis are inconsistent. We performed a meta‐analysis of the literature to highlight key points that might help in understanding the association between age of oral tongue cancer patients at diagnosis and their prognosis. According to age at diagnosis, a systematic literature review of all published cohort studies assessing the recurrence risks and mortality associated with tongue cancer was conducted. We compared the risk estimates between patients aged >45 years and those aged <45 years at diagnosis. Random‐effects models were used to calculate summary relative risk estimates (SRRs) according to different clinical outcomes and sources of between‐study heterogeneity (I2) and bias. We included 31 independent cohort studies published between 1989 and 2019; these studies included a total of 28,288 patients. When risk estimations were not adjusted for confounders, no significant association was found between age at diagnosis and overall survival (OS). Conversely, after adjustment for confounders, older age at diagnosis was associated with a significantly increased risk of mortality. The difference between SRRs for adjusted and unadjusted estimates was significant (p < 0.01). Younger patients had a significantly higher risk of local recurrence. Younger patients with oral tongue cancer have better OS but a greater risk of recurrence than older patients. These findings should be validated in a large prospective cohort study which considers all confounders and prognostic factors.

show abstract

Squamous cell carcinoma of the oral tongue in young patients: a matched-pair analysis

Abstract: Stage and treatment modality were similar in the two age groups. There were significant differences in overall survival (p=0.013) and disease-specific survival (p=0.046) favoring young patients. Rates of locoregional recurrence and distant metastasis were higher in the older patients.

Cited by 35 publications

References 23 publications

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Clinical and histopathological evidence of oral squamous cell carcinoma in young patients: systematized review

Estimating Survival After Salvage Surgery for Recurrent Oral Cavity Cancer

A systematic review and meta‐analysis of the prognostic role of age in oral tongue cancer

Contact Info

Product

Resources

About