Squamous Cell Carcinoma of the Anal Sac in Five Dogs

Esplin, D. G.; Wilson, Stephanie R.; Hullinger, Gordon A.

doi:10.1354/vp.40-3-332

Cited by 32 publications

(24 citation statements)

References 2 publications

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“…The proliferating cells revealed moderate cellular pleomorphism, large vesicular nuclei, prominent nucleoli and variable mitotic activity. Similar microscopic observations have been reported [40-47]. …”

Section: Case Presentationsupporting

confidence: 92%

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

et al. 2014

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BackgroundSquamous cell carcinomas (SCCs) are uncommon, high-grade tumors, predominantly composed of round cells in the prepuce. The aim of this study is to better define the clinicopathologic features of this neoplasm.Case reportWe conducted cyto-histopathologic analysis on the manifestations of the prepuce SCC by H & E staining in a terrier mix dog. Grossly, tumor was large, multiple erythematous patch, and ulcerated masses frequently affecting the prepuce and deeply invading to distal prepuce out from the ventro-lateral of penis and the tumor covered by a necrotic discharge. Cytological evaluation of fine-needle aspirates from the cutaneous mass from the prepuce comprised of round nuclei, coarse chromatin pattern, distinct nucleoli and nuclear pleomorphism. Furthermore, the neoplastic cells were pleomorphic, round to caudate in shape, exhibiting prominent anisokaryosis and anisocytosis with rare mitotic features. Microscopically, the lesions were predominantly composed of atypical round cells disposed in interlacing fascicles. Frequent findings include keratin formation, horn pearls, mitoses and cellular atypia. The cells showed distinct borders, ranged from polygonal to round or elongate and had moderate amounts of eosinophilic cytoplasm.ConclusionThe histopathologic features coupled with the cytopathology findings led to a diagnosis of squamous cell carcinoma. To the authors’ knowledge, this is the first time that multiple erythematous plaques have undergone malignant transformation in a terrier mix dog.Virtual SlidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5748771971272873

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Section: Case Presentationsupporting

confidence: 92%

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

et al. 2014

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“…The eventual role of S‐100 protein‐positive cells in the tumorigenesis of the dog's paranal sinus also deserves an attention. It is known that adenocarcinomas are prevailing (Meuten et al., ), while cases of squamous cell carcinomas of the paranal sinus are reported in both castrated and intact subjects (Esplin et al., ). Gulubova et al.…”

Section: Discussionmentioning

confidence: 99%

S‐100 Protein‐Positive Mast Cells in Canine Paranal Sinus (Sinus paranalis)

Stefanov

Vodenicharov

2013

Anat Histol Embryol

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The aim of this study was to establish the immunocytochemical expression of S-100 protein in mast cells, localized in the wall of dog's paranal sinus. Control serial sections were used for immunocytochemical detection of tryptase-positive mast cells. It was observed that S-100-positive cells have the same morphology and localization as the tryptase-positive mast cells, which indicated that S-100-positive cells are most probably mast cells with abilities as dendritic cells. In conclusion, for the first time, the current study gave evidence that mast cells in this organ possess one more function, such as dendritic cells.

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“…One of the commonest causes for these conditions is the impaired mechanisms of voiding the sinus content during defecation. Among tumours, adenocarcinomas are prevailing (Meuten et al., 1982), while cases of squamous cell carcinomas of the paranal sinus are reported in both castrated and intact subjects (Esplin et al., 2003).…”

Section: Introductionmentioning

confidence: 99%

NADPH‐d‐Positive Mast Cells in the Canine Paranal Sinus

Stefanov¹,

Vodenicharov

2011

Anat Histol Embryol

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This study aimed to investigate the enzyme histochemical expression of NADPH-d in mast cells in the wall of the paranal sinus in male and female dogs. NADPH-d-positive cells with weak, medium and strong enzyme histochemical expression were observed in the stroma of the sinus near the blood vessels of the microcirculatory bed and around the apocrine and sebaceous glands. In the same areas, mast cells with similar dimensions and morphology were demonstrated by metachromasia on paraffin and cryostat cross-sections and stained with 0.1% toluidine blue in McIlvane's buffer (pH 3). These findings suggest that the mast cells that are located in the stroma near the blood vessels, the lining epithelium and the glands correspond with the cells with marked NADPH-d activity. The possibility of mast cells having nitric oxide activity could be used in the regulation of mast cells function when treating paranal sinus tumours and inflammations.

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Squamous Cell Carcinoma of the Anal Sac in Five Dogs

Cited by 32 publications

References 2 publications

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

RETRACTED ARTICLE: Cyto-histopathological and outcome features of the prepuce squamous cell carcinoma of a mixed breed dog

S‐100 Protein‐Positive Mast Cells in Canine Paranal Sinus (Sinus paranalis)

NADPH‐d‐Positive Mast Cells in the Canine Paranal Sinus

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