Squamous cell carcinoma of the tongue: Experience with 86 consecutive cases

Abstract

Charts from 86 patients treated for carcinoma of the tongue were reviewed to identify strategies that might improve patient outcome. Seventy-one patients (83%) were black and 69 patients (80%) were male. Overall 2- and 5-year survival rates were 20% and 12%, with stage-specific 2-year survivals of 71% (I and II, n = 7), 33% (III, n = 15), and 11% (IV, n = 64) (P < 0.01). Patients with well-differentiated tumors (n = 27) had a higher 2-year survival than that of the others (n = 53, 30% vs. 11%, P = 0.05). Six were unclassified. Twenty-three (27%) patients underwent primary surgical resection and lymphadenectomy with or without adjuvant therapy. Two-year overall and disease-free survivals were 43% and 26%, respectively. Fifty (58%) patients received radiotherapy with or without chemotherapy, achieving 2-year overall and disease-free survivals of 12% and 6% (P < 0.01). The remaining 13 patients received chemotherapy alone or no treatment and survived an average of 6 months. Distant metastasis were diagnosed in 14 patients (16%). Tongue carcinoma in this socioeconomic setting was characterized by late diagnosis and poor prognosis. Degree of tumor differentiation, disease stage, and treatment modality seemed to correlate with prognosis. Surgery, when possible, achieved superior results for disease control and survival. While cancer prevention efforts are critical, steps to identify high-risk groups to implement early detection programs may help improve outcome for these patients.

Squamous cell carcinoma of the tongue in young adults: Increasing incidence and factors that predict treatment outcomes

“…That increased tumor size and nodal stage and the presence of distant metastases were all correlated with decreased survival came as no surprise and confirmed the results of previous series 11 , 12 . The same can be said for the findings that pathologic criteria such as close margins, perineural invasion, lymphatic invasion, and vascular invasion were correlated with decreased survival 9 …”

“…That increased tumor size and nodal stage and the presence of distant metastases were all correlated with decreased survival came as no surprise and confirmed the results of previous series. 11,12 The same can be said for the findings that pathologic criteria such as close margins, perineural invasion, lymphatic invasion, and vascular invasion were correlated with decreased survival. 9 Finally, the improved survival rate that was seen in patients whose primary treatment included neck dissection supports our institutional policy that all patients with SCCOT who are treated surgically should undergo neck dissection for prognostic and therapeutic purposes.…”

ATM in oral carcinogenesis: association with clinicopathological features

“…Despite the improvements in surgical techniques and chemotherapies or radiotherapies, OSCC still represents a clinical challenge due to their prognosis being poor (Reichard et al 1993). The lack of improvement on the survival rate for cases with OSCC emphasizes the search for novel molecular markers associated with the initiation and biological behavior of this tumor with the aim to beneWt the patients.…”

Lewisy Promotes Migration of Oral Cancer Cells by Glycosylation of Epidermal Growth Factor Receptor

“…Oral cancer may be curable with early diagnosis and treatment; however, the survival rate is decreased in the advanced-stages. [ 3 ] Depending on the originating tissues, there are several types of oral cancers. Oral squamous cell carcinoma (OSCC), which occurs in the lining mucosa of the mouth and lips, is the most common and has become an epidemiological issue around the world.…”