Squamous cell carcinoma of the nasal cavity: A population‐based analysis

Abstract

4. Laryngoscope, 126:560-565, 2016.

Impact of anatomic origin of primary squamous cell carcinomas of the nasal cavity and ethmoidal sinus on clinical outcome

“…patients. This is in line to former studies demonstrating that nodal involvement represents a significantly worse prognostic factor that cut patients’ overall survival almost to a half compared to node-negative patients [10, 19]. …”

“…In the meta-analysis of Scurry et al, reviewing 23 studies, the risk for regional recurrence was 18.1%, and therefore, they favor elective regional treatment [11]. Conversely, other authors recommend elective treatment only for T4 tumors [10]. However, according to Ahn et al, elective nodal treatment could lead to a five- to sixfold decrease of nodal recurrence in sinonasal carcinomas [2].…”

Differentiation of olfactory neuroblastomas from nasal squamous cell carcinomas using MR diffusion kurtosis imaging and dynamic contrast‐enhanced MRI

“…Recent studies have shown that other common small round cell malignant tumors, such as lymphoma and rhabdomyosarcoma, can be differentiated from SCCs by measurements of ADC values, revealing that D values of DKI may also be useful in the discrimination of ONBs and SCCs. However, we found no significant differences between these two entities, perhaps because SCC is also a common type of sinonasal malignant tumor with densely packed tumor cells, which may restrict water diffusion . Furthermore, there existed a considerable overlap of D values between ONBs and SCCs, which may be another possible reason to interpret no significant difference of D values between the two entities and that need to be further verified with a larger sample size.…”

“…However, we found no significant differences between these two entities, perhaps because SCC is also a common type of sinonasal malignant tumor with densely packed tumor cells, which may restrict water diffusion. 27 Furthermore, there existed a considerable overlap of D values between ONBs and SCCs, which may be another possible reason to interpret no significant difference of D values between the two entities and that need to be further verified with a larger sample size. Notably, in this study the mean K value of ONBs was found to be significantly higher than that of SCCs, revealing that the internal microstructure of ONBs was more complex than that of SCCs.…”

Clinical effects of p53 overexpression in squamous cell carcinoma of the sinonasal tract

“…[8] Recently, accumulating evidence suggests that a number of genetic alterations may contribute to the initiation and progression of SNSCC. [9–12] The p53 gene is a tumor suppressor gene mapped to chromosome 17p13, encodes the p53 protein, which involves in the regulation of the cell cycle, the inhibition of DNA synthesis, the function of DNA repair and apoptosis.…”