Squamous cell carcinoma of the head and neck outside the oropharynx is rarely human papillomavirus related

Upile, Navdeep; Shaw, Richard; Jones, Terry M.; Goodyear, P; Liloglou, Triantafillos; Risk, Janet M.; Boyd, Mark T.; Sheard, Jon; Sloan, P; Robinson, Max; Schache, Andrew

doi:10.1002/lary.24828

Cited by 55 publications

(41 citation statements)

References 17 publications

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“…8 studies investigated OSCC only and 10 investigated HNSCC. Despite the higher prevalence of HPV and p16 in OSCC [74], we included all HNSCC locations in this meta-analysis to increase the total number of patients and studies and to allow for a separate evaluation of the discrepant cases (HPV ? /p16 -and HPV -/p16 ?…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of survival in patients with HNSCC discriminates risk depending on combined HPV and p16 status

Coordes

Lenz

Qian

et al. 2015

Eur Arch Otorhinolaryngol

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Data indicate a better prognosis for human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC). HPV and p16 detection are established markers for HPV-related HNSCC. Both are accepted as survival-independent predictors. Previous studies investigating the survival in HNSCC patients depending on HPV(+/-) and p16(+/-) status consistently found discordant results with p16(-)/HPV(+) and p16(+)/HPV(-). However, no meta-analysis regarding the survival according to combined HPV/p16 status has been performed yet. The objective of this study was to discriminate the impact of combined HPV(+/-) and p16(+/-) status on survival. Data sources were identification and review of publications assessing survival of the distinct subgroups with both p16 and HPV investigated in HNSCC until February, 2015. A meta-analysis was performed to classify survival and clinical outcomes. 18 out of 397 articles (4424 patients) were eligible for the meta-analysis. The percent proportion of the subgroups was 25 % for HPV(+)/p16(+), 61.2 % for HPV(-)/p16(-), 7.1 % for HPV(-)/p16(+) and 6.8 % for HPV(+)/P16(-). The meta-analysis showed a significantly improved 5-year overall survival (OS), 5-year disease-free survival and their corresponding hazard ratio for HPV(+)/p16(+) HNSCC in comparison to HPV(-)/p16(-), HPV(+)/p16(-) and HPV(-)/p16(+). The 5-year OS of the HPV(-)/p16(+) subgroup was intermediate while HPV(+)/p16(-) and HPV(-)/p16(-) HNSCC had the shortest survival. With current therapeutic strategies, survival of patients with HNSCC is better if associated with HPV(+)/p16(+) or HPV(-)/p16(+). Clinical trials are needed to confirm the distinct survival pattern and to investigate possible differences in survival for HPV(+)/p16(-) and HPV(-)/p16(+) HNSCC. To further differentiate p16(+) HNSCC, HPV testing may be advisable.

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Section: Discussionmentioning

confidence: 99%

Meta-analysis of survival in patients with HNSCC discriminates risk depending on combined HPV and p16 status

Coordes

Lenz

Qian

et al. 2015

Eur Arch Otorhinolaryngol

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“…There is evidence that HPV also infects the gingival tissue with periodontal pocket; the only location that is exposed to the external environment [33][34][35]. Wide-ranging studies analyzing large number of patients and describing anatomic subsites, as well HPV DNA frequency per site, indicate that HPV can be found in any of the subsites [8,10,22,[36][37][38][39][40]. Subsite frequencies are varying between studies, but floor of mouth (9-42 %) and the tongue (8-25 %) seem to be predominantly infected by HPV.…”

Section: Discussionmentioning

confidence: 99%

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

Singh

Kushwaha

Anand

et al. 2016

Indian J Surg Oncol

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Human papilloma virus (HPV)-associated head and neck cancer (HNC) has generated significant amount of research interest in recent times with focus shifted to oral cavity squamous cell cancer (OCSCC) after oropharyngeal cancer. Due to high incidence of OCSCC and anecdotal reports on association of HPV infection from northern region of India, this study was conceived to investigate HPV infection and establish its association with lifestyle habits such as tobacco, alcohol consumption, oro-genital sex, number of sexual contacts, and change in quality of life posttreatment. A total of 43 primary OCSCC biopsy specimens were collected. These samples were analyzed for HPV DNA genotyping which was done by using 13 high-risk HPV real-time PCR kits. Quality of life was assessed using University of Washington questionnaire for HNC patients, which was administered pretreatment and 3-months posttreatment. HPV presence was confirmed in only three patients (7.0 %). HPV positivity did not find any statistical correlation with age, gender, residence, addiction habit, stage, tumor size, nodal status, tumor grade, and number of sexual contacts. There was no significant (p > 0.05) difference in the average percent change in QOL parameters from pretreatment to posttreatment when correlated with HPV status.

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“…Beside the general term 'oral cavity' used in several studies, it is difficult to estimate the specific prevalence of HPV DNA for the individual sub-sites. Comprehensive studies testing larger numbers of patients (>80 ) and describing anatomic subsites as well as HPV DNA frequency per site indicate that HPV can be found in any of the sub-sites, 19,24,31,50,[52][53][54][55] (Table 1). Frequencies are varying between studies, but floor of mouth (9-42%) and the tongue (8-25%) seem to be predominantly infected by HPV.…”

Section: Subclinical and Premalignant Oral Hpv Infectionmentioning

confidence: 99%

HPV and cancer of the oral cavity

2015

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Squamous cell carcinoma of the head and neck outside the oropharynx is rarely human papillomavirus related

Abstract: 4 Laryngoscope, 124:2739-2744, 2014.

Cited by 55 publications

References 17 publications

Meta-analysis of survival in patients with HNSCC discriminates risk depending on combined HPV and p16 status

Meta-analysis of survival in patients with HNSCC discriminates risk depending on combined HPV and p16 status

Human Papilloma Virus in Oral Cavity Cancer and Relation to Change in Quality of Life Following Treatment—a Pilot Study from Northern India

HPV and cancer of the oral cavity

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