Squamous cell carcinoma of the penis

Micali, Giuseppe; Innocenzi, D.; Nasca, Maria Rita; Musumeci, Maria Letizia; Ferraú, Francesco; Greco, Manfredi

doi:10.1016/s0190-9622(96)90611-8

Cited by 68 publications

(86 citation statements)

References 156 publications

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“…In some developing countries, penile SCC is more common and affects a somewhat wider age range (5)(6)(7)(8)(9). The etiology of penile SCC remains incompletely understood (7,10).…”

Section: Introductionmentioning

confidence: 99%

“…In some developing countries, penile SCC is more common and affects a somewhat wider age range (5)(6)(7)(8)(9). The etiology of penile SCC remains incompletely understood (7,10). Studies have consistently reported neonatal or childhood circumcision to be associated with reduced risk (1,4,6,(10)(11)(12), which corresponds geographically with reduced rates of penile SCC in populations practicing neonatal circumcision (13).…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors for Squamous Cell Carcinoma of the Penis—Population-Based Case-Control Study in Denmark

Madsen

Brule²,

Jensen

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

112

103

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Few etiologic studies of squamous cell carcinoma (SCC) of the penis have been carried out in populations where childhood circumcision is rare. A total of 71 patients with invasive (n = 53) or in situ (n = 18) penile SCC, 86 prostate cancer controls, and 103 population controls were interviewed in a population-based casecontrol study in Denmark. For 37 penile SCC patients, tissue samples were PCR examined for human papillomavirus (HPV) DNA. Overall, 65% of PCR-examined penile SCCs were high-risk HPV-positive, most of which (22 of 24; 92%) were due to HPV16. Penile SCC risk was positively associated with measures of early and high sexual activity, including lifetime number of female sex partners, number of female sex partners before age 20, age at first intercourse, penile-oral sex, a history of anogenital warts, and never having used condoms. Histories of phimosis and priapism at least 5 years before diagnosis were also significant risk factors, whereas alcohol abstinence was associated with reduced risk. Our study confirms sexually transmitted HPV16 infection and phimosis as major risk factors for penile SCC and suggests that penileoral sex may be an important means of viral transmission. The association with priapism was unexpected and needs replication. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2683 -91)

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“…In some developing countries, penile SCC is more common and affects a somewhat wider age range (5)(6)(7)(8)(9). The etiology of penile SCC remains incompletely understood (7,10).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk Factors for Squamous Cell Carcinoma of the Penis—Population-Based Case-Control Study in Denmark

Madsen

Brule²,

Jensen

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

112

103

View full text Add to dashboard Cite

show abstract

“…The differentiation between EQ and BD has been a continuing source of confusion; it is now accepted that EQ is BD localized to the glans penis or foreskin [3]. Untreated BD may develop approximately in 5% of cases into invasive squamous cell carcinoma, the malignant progression of EQ is reported to be more common with an incidence varying from 10 to 33% [16]. In contrast, BP has a completely benign course with no present evidence suggesting a potential for malignant degeneration in young persons [6].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, BP has a completely benign course with no present evidence suggesting a potential for malignant degeneration in young persons [6]. In older patients with BP, there is no tendency to spontaneous regression, in some cases the coexistence of BP and invasive cancer has been reported [16]. …”

Section: Discussionmentioning

confidence: 99%

“…In several publications the treatment of choice for EQ is Mohs’ micrographic surgery, some authors even prefer more aggressive therapy like partial or total penectomy [6, 16, 17]. Treatment options with photodynamic therapy have failed to achieve a long-term response; in 1 case a squamous cell carcinoma developed after topical 5-aminolaevulinic acid photodynamic therapy [19, 20].…”

Section: Discussionmentioning

confidence: 99%

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