Squamous cell carcinoma of the middle rectum: Report of a case and literature overview

Scaringi, Stefano; Bisogni, Damiano; Messerini, Luca; Bechi, Paolo

doi:10.1016/j.ijscr.2014.10.097

Cited by 8 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This theory is supported by the fact that squamous carcinoma is often found in the midst of poorly differentiated cells; 3. Michelassi et al (18) have suggested that epithelial damage causes proliferation of uncommitted basal cells into squa-mous cells which then undergo malignant transfor-mation; 4. Histological reviews of adeno-carcinomas have demonstrated areas of squamous differentiation, suggesting the possibility that these carcinomas may arise out of pre-existing adenomas or adenocarci-nomas (19).…”

Section: Discussionmentioning

confidence: 99%

Anal Carcinoma: A Series of Cases with a Literature Review

Stosic¹,

Stojanovic²,

Mihajlovic³

et al. 2016

Acta Facultatis Medicae Naissensis

View full text Add to dashboard Cite

The aim of this study was to analyze the cases of five patients with squamous cell carcinoma (SCC)and to draw attention to the dilemma in the treatment of incontinence on admission of these patients and to present, through a literature review, locations of the surgical treatment.The anal carcinoma is a rare disease which involves different histopathological (HP) types of cancer. They account for about 2.5% of all digestive cancers. The treatment of the disease is multimodal. There are dilemmas about screening of precancerous lesions and treatment of diagnosed incontinence. There is a high similarity between HPV infection and SCC. Our methods and results were compared with the data from the literature.In the period of three years (from 2013 to 2015), five cases of the anal carcinoma were diagnosed and treated in the regional hospital. In all of our cases, the disease was histopathologically confirmed as SCC of the anal and perianal areas. It excluded the cases of anal adenocarcinoma (AAC).Nearly half of the patients (40%) were incontinent and the rectum excision was one of the possible solutions. Distinction in histopathological structure created the confusion in the treatment of these patients. The dilemma we had was whether to do an amputation of the rectum in patients with incontinence before the standardized Chemoradiation therapy (CRT). The review of the literature sums up certain conclu-sions.The diagnosis of SCC includes the perianal "ulcer" that does not heal, as well as atypical anoperianal growths. Surgical treatment of SCC is indicated when the diameter of lesion is small (2 cm), or the disease is persistent or recurrent. In the case of anal incontinence because of the tumor changes, the abdominoperineal resection of the rectum (APR) is an alternative to performing bipolar colostomy and CRT. The review of the literature using MEDLINE/PubMed databases did not find the case with restoring anal continence after this treatment. Testing a larger number of patients with incontinence on admission would provide a more clear answer to the question of the treatment of these patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Anal Carcinoma: A Series of Cases with a Literature Review

Stosic¹,

Stojanovic²,

Mihajlovic³

et al. 2016

Acta Facultatis Medicae Naissensis

View full text Add to dashboard Cite

show abstract

“…Squamous cell carcinoma (SCC) of the gastrointestinal (GI) tract most commonly occurs in the esophagus or anal canal, and prior studies report a <1% incidence within the rectum . Due to its rarity, the etiology of SCC of the rectum remains unclear, although it has been linked to chronic inflammation and prior radiotherapy . A recent Surveillance, Epidemiology, and End Results (SEER) analysis showed those with SCC to have a favorable prognosis compared to adenocarcinoma of the rectum .…”

Section: Introductionmentioning

confidence: 99%

Squamous cell carcinoma of the rectum: Practice trends and patient survival

et al. 2018

View full text Add to dashboard Cite

PurposeLeverage the National Cancer Database (NCDB) to evaluate trends in management of nonmetastatic squamous cell cancer (SCC) of the rectum and their effect on survival for this uncommon tumor.Methods and MaterialsRetrospective data was obtained from the NCDB for patients diagnosed with SCC of the rectum between 2004 and 2014, including cT1‐4, cN0‐2, cM0 tumors (cohort A, n = 2296). A subgroup analysis was performed on locally advanced tumors (cT1‐T2, N+ or cT3, N any, subcohort B, n = 883), treated with chemoradiation (n = 706) or trimodality therapy (n = 177) including chemotherapy, radiation, and surgery. Pathological complete response rate following neoadjuvant therapy was obtained. Univariate and multivariate logistic regression analyses were performed to generate hazard ratios (HR) investigating factors associated with overall survival. Kaplan‐Meier (K‐M) method was used to estimate overall surviving proportion at 5 and 10 years.ResultsThe K‐M estimated 5 and 10 year overall survival for stage I disease was 71.3% and 57.8%, respectively; stage II disease was 57.0% and 38.9%, respectively; stage III disease was 57.8% and 41.5%, respectively. On multivariate analysis, higher cT category (P < 0.001) resulted in worse survival. For locally advanced tumors (subcohort B), there was no significant difference in survival between chemoradiation alone compared to trimodality therapy (P = 0.909 on multivariate analysis).ConclusionsMost providers manage locally advanced SCC of the rectum similar to anal cancer, which results in equivalent overall survival and spares patients from the additional morbidity associated with surgical resection.

show abstract

“…Most cases of rectal SCC are actually anal SCC with proximal extension into the rectum, which is different from primary SCC of the rectum. The estimated incidence of primary rectal SCC is approximately 0.01%–0.025% of all colorectal neoplasms [ 2 ]. William et al [ 3 ] established the following criteria to define SCC of rectal origin: (1) metastasis from other organs to the rectum must be ruled out; (2) there is an absence of anal involvement with SCC; and (3) an anal SCC-lined fistula with the rectum must be ruled out.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Immunohistochemical Staining in Differentiating a Squamous Cell Carcinoma in Poorly Differentiated Rectal Cancer: Two Case Reports

et al. 2016

View full text Add to dashboard Cite

A rectal carcinoma, including primary an adenosquamous and a squamous cell carcinoma (SCC), is a very rare disease, accounting for 0.025% to 0.20% of all large-bowel malignant tumors. Because SCCs have a higher mortality than adenosquamous carcinomas, determining whether the primary rectal cancer exhibits an adenomatous component or a squamous component is important. While differentiating between these 2 components, especially in poorly differentiated rectal cancer, is difficult, specific immunohistochemical stains enable accurate diagnoses. Here, we report the use of immunohistochemical stains to distinguish between the adenomatous and the squamous components in 2 patients with low rectal cancer, a 58-year-old man and a 73-year-old woman, who were initially diagnosed using the histopathologic results for a poorly differentiated carcinoma. These data suggest that using these immunohistochemical stains will help to accurately diagnose the type of rectal cancer, especially for poorly differentiated carcinomas, and will provide important information to determine the proper treatment for the patient.

show abstract

Squamous cell carcinoma of the middle rectum: Report of a case and literature overview

Cited by 8 publications

References 14 publications

Anal Carcinoma: A Series of Cases with a Literature Review

Anal Carcinoma: A Series of Cases with a Literature Review

Squamous cell carcinoma of the rectum: Practice trends and patient survival

Efficacy of Immunohistochemical Staining in Differentiating a Squamous Cell Carcinoma in Poorly Differentiated Rectal Cancer: Two Case Reports

Contact Info

Product

Resources

About