Squamous cell carcinoma of the buccal mucosa involving the masticator space: a case report

Kim, Il-hyung; Myoung, Hoon

doi:10.5125/jkaoms.2017.43.3.191

Cited by 17 publications

(10 citation statements)

References 25 publications

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“…Buccal tumours behaved more aggressively than other tumours, exhibiting higher risks of progressive disease and reduced survival. Probably, a consequence of initial loco‐regional recurrence, characterised by ready infiltration of subjacent buccinator muscle, buccal fat and extension to pterygoid musculature and upper and lower alveolus, such poor outcome may imply an inherent biological tendency to aggressive behaviour that warrants further investigation 18‐21 …”

Section: Discussionmentioning

confidence: 99%

Statistical profiling of oral cancer and the prediction of outcome

Wang

Adeoye

Thomson

et al. 2020

J Oral Pathology Medicine

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Background The global burden of oral squamous cell carcinoma (OSCC) remains formidable. Identifying factors predictive of aggressive tumour behaviour, disease progression and reduced survival time may assist in early identification of “high‐risk” patients and appropriately target combination cancer therapies. Methods A retrospective review of 467 OSCC patients treated over a 19‐year period facilitated detailed clinico‐pathological database analysis and determination of clinical outcome categories based upon time to progressive disease (loco‐regional tumour recurrence and/or distant metastasis), overall death and OSCC‐related death (death directly attributable to OSCC). Odds ratio (OR) and hazard ratio (HR) statistical measures were used to investigate relationships between patient demographics and clinico‐pathological tumour features with clinical outcome. Results Older age at presentation (P = .002) and a history of previous non–head and neck cancer (P = .010) increased the risk of overall death. OR for progressive disease development (P = .008) and OSCC‐related death (P = .019) was most significant for buccal tumours. HR confirmed advanced‐stage disease increased the risk of progressive disease (P < .001), overall death (P < .001) and OSCC‐related death (P < .001). Positive resection margins were associated with a higher risk of OSCC‐related death (P = .023). Significantly lower risks of progressive disease development (P = .002) and OSCC‐related death (P = .012) were seen in patients undergoing neck dissection, whilst combination chemoradiotherapy reduced HR for overall death (P < .001) and OSCC‐related death (P = .011). Conclusion Statistical profiling of OSCC clinico‐pathological data identifies significant influences on clinical outcome. This study adds evidence to the hypothesis that buccal SCC displays aggressive tumour behaviour and poor clinical outcome.

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Section: Discussionmentioning

confidence: 99%

Statistical profiling of oral cancer and the prediction of outcome

Wang

Adeoye

Thomson

et al. 2020

J Oral Pathology Medicine

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“…6,7 A single-institution study of 25 patients recently suggested a benefit of adjuvant chemoradiotherapy (CRT) to primary surgery and a disease-specific survival of 63.2% at 2 years. 9 With more advanced techniques being developed for surgical access to the masticator space, 10,11 it seems justified to reassess the very locally advanced classification of these lesions (unresectable in the prior editions). We utilized the National Cancer Database (NCDB), the largest cancer database in the United States, to analyze the patterns of treatment of patients with T4b OCSCC and associated outcomes.…”

mentioning

confidence: 99%

Primary Surgical Treatment in Very Advanced (T4b) Oral Cavity Squamous Cell Carcinomas

Patel¹,

Oliver²,

Vaezi³

et al. 2021

Otolaryngol.--head neck surg.

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Objectives To describe patterns of primary surgical treatments in patients with T4b oral cavity squamous cell carcinoma (OCSCC). Study Design Historical cohort study. Setting National Cancer Database. Methods Review of the National Cancer Database between 2004 and 2017 for all T4b OCSCCs. Only patients with curative treatment methods were included in the survival analysis. Surgical and nonsurgical outcomes were compared by multivariable and propensity score matching analysis. Results A total of 1515 cases of T4b OCSCC were identified. A minority of patients (n = 363, 24.0%) underwent curative treatment; among these, 206 (56.7%) underwent primary surgery. Median length of follow-up was 24 months. The 90-day mortality of patients who underwent surgical treatment was 1.0%. The 2-year survival was higher for patients who underwent surgery + chemoradiotherapy (CRT) as compared with CRT (64.6% vs 45.2%, P < .001). On multivariable analysis, surgery + CRT was associated with longer survival. In a propensity score–matched cohort of 312 patients, 2-year survival remained higher in the surgical group versus the nonsurgical group (59.4% vs 45.5%, P = .02). Among patients who underwent surgery + CRT, there was no difference in 2-year survival between clinical T4a and T4b (59% vs 64.6%, P = .20). Conclusions A minority of patients with T4b OCSCC undergo treatments with curative intent. A subset of patients underwent primary surgical treatment, which was associated with longer survival. The T4b classification might entail a heterogenous group, and further studies in revision of this classification might be justified.

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“…Particularly the floor of the mouth guarantees mobility of the tongue; thus, defects in this region significantly impair swallowing, mastication, and speaking. In contrast, reconstructed defects in the buccal mucosa are more associated with salivary retention and pain [21, 29]. The tongue is also essential for propulsion processes.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life: a retrospective study on local vs. microvascular reconstruction in patients with oral cancer

Meier¹,

Schuderer²,

Zeman³

et al. 2019

BMC Oral Health

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Background New medicinal and surgical oncological treatment strategies not only improve overall survival rates but continually increase the importance of Health-Related Quality of Life (HRQOL). The purpose of this retrospective cross-sectional study was to analyze HRQOL of patients with oral squamous cell carcinoma after ablative surgery and to evaluate predictive factors for HRQOL outcome. Methods The study included 88 patients with histologically confirmed oral squamous cell carcinoma of whom 42 had undergone local reconstruction (LR) and 46 microvascular reconstruction (MVR). During follow-up, all patients completed the University of Washington Quality of Life Questionnaire (UW-QOL) containing 12 targeted questions about the head and neck. Descriptive analyses were made for the tumor site, the T-stage, and adjuvant therapies. HRQOL was compared between the LR and the MVR group with parametric tests. Further analyses were impact of the tumor site, the T-status, and the time from surgery to survey on HRQOL. Statistics also included multivariate correlations and different interaction effects. Results HRQOL in the LR group was ‘very good’ with 84.3 ± 13.7 and ‘good’ in the MVR group with 73.3 ± 16.5 points. The physical domains swallowing ( p = 0.00), chewing ( p = 0.00), speech ( p = 0.01), taste ( p = 0.01), and pain ( p = 0.04) were significantly worse in the MVR group. An increase in the T-status had a significant negative effect on swallowing ( p = 0.01), chewing ( p = 0.01), speech ( p = 0.03), recreation ( p = 0.05), and shoulder ( p = 0.01) in both groups. Regarding the tumor site and subsequent loss of HRQOL, patients with squamous cell carcinoma on the floor of the mouth had significantly worse results in the categories pain ( p = 0.002), speech ( p = 0.002), swallowing ( p = 0.03), activity ( p = 0.02), and recreation ( p = 0.01) than patients with tumors in the buccal mucosa. Speech ( p = 0.03) and pain ( p = 0.01) had improved 1 year after surgery. Conclusion Patients with flap reconstruction because of oral squamous cell carcinoma showed very good overall HRQOL. Outcomes for microvascular reconstruction were good, even in the case of larger defects. The T-status is a predictor for HRQOL. Swallowing, chewing, speaking, taste, and pain were the most important issues in our cohort. Implementing HRQOL questionnaires for the assessment of quality of life could further increase the treatment quality of patients with oral cancer.

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Squamous cell carcinoma of the buccal mucosa involving the masticator space: a case report

Cited by 17 publications

References 25 publications

Statistical profiling of oral cancer and the prediction of outcome

Statistical profiling of oral cancer and the prediction of outcome

Primary Surgical Treatment in Very Advanced (T4b) Oral Cavity Squamous Cell Carcinomas

Health-related quality of life: a retrospective study on local vs. microvascular reconstruction in patients with oral cancer

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