Squamous cell carcinoma of the colon: evaluation of treatment modalities and survival

Larkins, Michael C.; Bhatt, Arjun; Irish, William; Kennedy, Katie N.; Burke, Aidan; Armel, Kristen; Honaker, Michael D.

doi:10.1016/j.gassur.2024.05.007

Journal of Gastrointestinal Surgery

2024

DOI: 10.1016/j.gassur.2024.05.007

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Squamous cell carcinoma of the colon: evaluation of treatment modalities and survival

Michael C. Larkins,

Arjun Bhatt,

William Irish

et al.

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2024

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Cited by 1 publication

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Colonic Adenosquamous Carcinoma: A Single-Center Review of Patient Clinicopathologic Characteristics, Genetics, and Clinical Outcomes

Lieb,

M. Thompson,

Verheij

et al. 2024

Cancers

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(1) Background: Adenosquamous carcinoma (ASC) is a rare subtype of colon cancer. Its rarity makes characterization challenging, although colonic ASC is believed to present at more advanced stages and have worse outcomes versus adenocarcinoma. This study aims to characterize the clinicopathological characteristics and clinical outcomes of colonic ASC. (2) Methods: This is a single-center, retrospective review of patients diagnosed with colonic ASC from 2000 to 2020. Data extracted included patient demographics, staging at diagnosis, tumor clinicopathologic and genetic characteristics, and clinical outcomes. (3) Results: Among 61,126 patients with colorectal cancer, 13 (0.02%) had colonic ASC, with a mean age at diagnosis of 48.7 years. The cecum/ascending colon was the most common primary site (6/13, 46.2%), and all except one patient was diagnosed with Stage III or IV disease. Among the eight patients with mismatch repair genetics available, only one was mismatch repair deficient. Eleven patients (84.6%) underwent surgery, and 11 likewise received some form of chemotherapy. Recurrence occurred in 7 of 13 patients (53.8%), and the overall five-year survival rate was 38.5%. The median survival rate was 39.4 months overall (30.5 months for Stage III, 23.7 months for Stage IV). (4) Conclusions: Overall, colonic ASC is rare, and this cohort of colonic ASC patients demonstrated advanced stage at diagnosis, frequent recurrence, and poor overall survival. Additional research remains to compare these characteristics with those of comparably staged adenocarcinoma and to develop specific management recommendations.

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Colonic Adenosquamous Carcinoma: A Single-Center Review of Patient Clinicopathologic Characteristics, Genetics, and Clinical Outcomes

Lieb,

M. Thompson,

Verheij

et al. 2024

Cancers

View full text Add to dashboard Cite

show abstract

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Squamous cell carcinoma of the colon: evaluation of treatment modalities and survival

Cited by 1 publication

References 15 publications

Colonic Adenosquamous Carcinoma: A Single-Center Review of Patient Clinicopathologic Characteristics, Genetics, and Clinical Outcomes

Colonic Adenosquamous Carcinoma: A Single-Center Review of Patient Clinicopathologic Characteristics, Genetics, and Clinical Outcomes

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