Squamous Cell Carcinoma of the Kidney – Rarity Redefined: Case Series with Review of Literature

Singh, Vishwajeet; Sinha, Rahul Janak; Sankhwar, SN; Mehrotra, ana; Ahmed, Nisar; Mehrotra, Seema

doi:10.4172/1948-5956.1000028

Cited by 24 publications

(43 citation statements)

References 12 publications

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“…There are only isolated case reports and scant case series of such cases in the English literature [1–8]. Herein we report four cases of incidentally detected renal pelvis squamous cell carcinomas in patients having a history of staghorn renal calculi with hydronephrosis.…”

Section: Introductionmentioning

confidence: 95%

Incidentally Detected Squamous Cell Carcinoma of Renal Pelvis in Patients with Staghorn Calculi: Case Series with Review of the Literature

et al. 2011

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Squamous cell carcinoma of the renal pelvis is a rare neoplasm, often unsuspected clinically due to its rarity and ambiguous clinical and radiological features, and hence patients present at advanced stages resulting in poor prognosis. We report here four cases of incidentally diagnosed primary renal squamous cell carcinoma, treated at our hospital over a short span of one year, and review the relevant literature. Mean age of the patients (3 males, 1 female) was 60 years. All suffered from staghorn stones. Interestingly, renal carcinoma was unsuspected clinically in all patients. In one case, a computerised tomography scan showed a suspicious nodule. All underwent nephrectomy for nonfunctioning kidney. In just two cases, tumor was identified on gross examination, while the other two only showed thickened pelvis. Our series emphasises the need for pelvicalyceal biopsy during treatment for long-standing nephrolithiasis, and thorough sampling of the renal pelvis in nephrectomy specimen of such patients.

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Section: Introductionmentioning

confidence: 95%

Incidentally Detected Squamous Cell Carcinoma of Renal Pelvis in Patients with Staghorn Calculi: Case Series with Review of the Literature

et al. 2011

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“…[11] Metastatic disease survey is more shorter with reported median survival of 5 months. [12] In our case, the survival was only 6 months.…”

Section: Dıscussıonmentioning

confidence: 48%

Primary renal squamous cell carcinoma: a case report

CETINDAG¹

2015

TJ Oncol

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Böbreğin skuamöz hücreli karsinom patolojik tanısı literatür-de nadiren yer alır. Hastalık agresif tabiatlı, beş yıllık yaşam %10'dan az ve prognoz kötüdür. Yetmiş dört yaşında erkek hasta karın ağrısı ve kilo kaybı şikayetleri ile başvurdu. Sağ nefrektomi yapıldı. Patoloji raporu orta derece diferansiye skuamöz hücreli böbrek karsinomu varlığını gösterdi. Pozitron emisyon tomografi görüntülerinde kalıntı hastalık ve metastatik lenfadenopatiler izlendi. Adjuvan kemoterapi ve radyoterapi uygulandı ancak hastalık ilerledi ve patolojik tanıdan altı ay sonra hasta kaybedildi. Primer skuamöz hüc-reli karsinom agresif bir tümördür ve böbrek taşı ile güçlü bir ilişkisi vardır. Tümörün erken tespiti için böbrek taşı ve nonfonksiyone böbreği olan hastalar, yeni görüntüleme teknikleri ile incelenmeli ve daha iyi sonuçlar için cerrahi sonrası adjuvan kemoterapi-radyoterapi kombinasyonları ile agresif tedaviler uygulanmalıdır.Anahtar sözcükler: Kemoterapi; yoğunluk ayarlı radyoterapi; radyoterapi; böbrek skuamöz hücreli karsinomu.Pathologic diagnosis of squamous cell carcinoma (SCC) of the kidney is rarely reported in the literature. The disease is aggressive in nature and the prognosis is dismal with a 5-year survival rate of less than %10. A 74-year-old man admitted with abdominal pain and weight loss. Right nephrectomy was performed. Pathology report delineated moderately differentiated SCC of the kidney. Positron emission tomography demonstrated residual mass and metastatic lymph nodes. Adjuvant treatments with chemotherapy and radiotherapy were applied but the disease was progressed and the patient was dead six months after pathologic diagnosis. Primary SCC is an aggressive tumor and these tumors are strongly associated with renal stones, the patients with renal stones and non-functioning kidney should be carefully examined with newer imaging modalities for early detection of the tumor, and warrants aggressive treatment with surgery followed by adjuvant aggressive combination chemotherapy-radiotherapy that may provide a better outcome.

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“…Radiotherapy, chemotherapy or immunotherapy could be adopted, but the effect is limited and no survival benefit has been demonstrated from these treatments. 9 Furthermore, the prognosis of renal SCC is so poor that the 5-year survival rate is no more than 10% and most patients die within 1 year of surgery. 10 Therefore, early diagnosis is necessary.…”

Section: Xiao Et Almentioning

confidence: 99%

Renal calculus complicated with squamous cell carcinoma of renal pelvis: Report of two cases

Xiao¹,

Lei²,

He³

et al. 2015

CUAJ

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Longstanding renal calculus is a risk factor of squamous cell carcinoma (SCC) of the renal pelvis. It is highly aggressive and usually diagnosed at advanced stages with a poor prognosis. We present two cases of kidney stone complications with renal pelvic SCC. These two patients had a radical nephrectomy and the dissected tissues were renal pelvic SCC. Our cases further emphasize that renal pelvic SCC should be considered in patients with longstanding renal calculus. These cases contribute greatly to an early diagnosis and early treatment, both of which will significantly minimize the damage of, and markedly improve the prognosis of, renal pelvic SCC. IntroductionPrimary renal squamous cell carcinoma (SCC) affects less than 1% of all urinary tract neoplasms.1 SCC occurs more often in the urethra and urinary bladder than in the renal pelvis in males. This cancer is highly aggressive and usually progresses at the first diagnosis, leading to a poor prognosis. We present two cases of kidney stones with SCC of the renal pelvis. Case 1A 55-year-old female was hospitalized because of dull pain at the bilateral lumbar regions, worse on the right side for 1 month. She underwent two ureterolithotomies on both sides to remove ureteral calculus 10 years before. A palpable lump was found on the right loin. The urine examination showed hematuria (occult blood 3+) and infection (white blood cell 2+). The blood urea and serum creatine were 8.15 mmol/L and 101 umol/L, respectively. The total glomerular filtration rate (GFR) was 77.22 mL/min with 25% on the right kidney and 75% on the left. The X-ray revealed multiple calculi in both kidneys. An ultrasound detected calculi in both renal hydronephrosis and a 3 × 3-cm mass in the right kidney with retroperitoneal lymph nodes enlargement. A computed tomography (CT) scan revealed a tumour in the right renal pelvis, as well as calculi in both renal hydronephrosis. This irregular mass was 3 × 3 cm in the renal pelvic region without renal and portal venous tumour thrombus (Fig. 1a). No distant metastasis was found on CT. The ureteroscopy showed that the right ureter was normal. The patient underwent a radical nephrectomy. The histopathology examination showed a well-differentiated SCC with a wide range of tissue necrosis. The cancer infiltrated the renal parenchyma, but not lymph nodes (Fig. 1b). This patient was therefore diagnosed with renal pelvic SCC at stage III (T3N0M0). The patient recovered from surgery without complication, but regretfully rejected chemotherapy. She died 1 year later from metastatic liver tumour. Case 2A 61-year-old male complained of bilateral flank pain, especially at the right side, which lasted for 3 months. He was diagnosed with bilateral kidney stones, but rejected any therapy 5 years before. The current urine test showed hematuria (occult blood 2+) and infection (white blood cell 2+). The urine culture was negative and the cancer cell was negative in the urine cytology. The blood urea and serum creatine were 12.15 mmol/L and 301μmol/L, respective...

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Squamous Cell Carcinoma of the Kidney – Rarity Redefined: Case Series with Review of Literature

Cited by 24 publications

References 12 publications

Incidentally Detected Squamous Cell Carcinoma of Renal Pelvis in Patients with Staghorn Calculi: Case Series with Review of the Literature

Incidentally Detected Squamous Cell Carcinoma of Renal Pelvis in Patients with Staghorn Calculi: Case Series with Review of the Literature

Primary renal squamous cell carcinoma: a case report

Renal calculus complicated with squamous cell carcinoma of renal pelvis: Report of two cases

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