Squamous Cell Carcinoma of the Palatine Tonsils: FDG Standardized Uptake Value Ratio as a Biomarker to Differentiate Tonsillar Carcinoma from Physiologic Uptake

Abstract

The SUV(max) ratio represents an accurate imaging biomarker for differentiating tonsillar SCC from physiologic (18)F-FDG uptake.

Liver SULmeanat FDG PET/CT: Interreader Agreement and Impact of Placement of Volume of Interest

“…Institutional review board approval was obtained for this Health Insurance Portability and Accountability P ositron emission tomography (PET) is a valuable tool in diagnosis, staging, therapy assessment, and follow-up in various human solid tumors (1)(2)(3)(4)(5). PET studies for diagnosis and staging of cancer in clinical practice are typically interpreted by using qualitative methods in which the distribution and intensity of fluorine 18 fluorodeoxyglucose (FDG) uptake in potential tumor foci are compared with FDG uptake in normal structures such as the blood pool, muscle, brain, and liver (6).…”

18F-FDG Metabolic Tumor Volume and Total Glycolytic Activity of Oral Cavity and Oropharyngeal Squamous Cell Cancer: Adding Value to Clinical Staging

“…Despite sharing a common histologic classification, HNSCC includes a heterogeneous mix of cancers with different natural histories that are historically defined best by site of origin and TNM staging (2). PET/CT has become increasingly important in localizing and staging HNSCC, identifying unknown primaries, detecting synchronous primaries, assessing therapy response, and monitoring for cancer recurrence (3)(4)(5).…”

“…Identification of novel pretreatment imaging biomarkers that potentially predict long-term outcome is of great interest. PET/CT standardized uptake value (SUV) measurements are reproducible imaging biomarkers that have diagnostic and prognostic value in HNSCC in general (5,6) and in oral and oropharyngeal SCC specifically (7). Recently, 18 F-FDG metabolic tumor volume (MTV) and total glycolytic activity (TGA) have been reported as additional diagnostic and prognostic imaging biomarkers in various human solid tumors (8)(9)(10)(11).…”

PET/CT Imaging and Human Papilloma Virus–Positive Oropharyngeal Squamous Cell Cancer: Evolving Clinical Imaging Paradigm

“…PET/CT is a useful imaging test in staging, therapy response assessment, and follow-up of patients with many human solid tumors (7)(8)(9)(10)(11)(12), including head and neck cancers (13)(14)(15)(16)(17). The objective of this article is to review the evolving role of PET/ CT in staging, therapy response assessment, and follow-up of patients with HPV-positive OPSCC.…”