Squamous Cell Carcinoma of the Lip—A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction

Bota, James; Lyons, Alexis B.; Carroll, Bryan T.

doi:10.1097/dss.0000000000001020

Cited by 31 publications

(28 citation statements)

References 87 publications

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“…A pesar de englobarse dentro de los tumores de la cavidad oral, según American Joint Committee on Cancer, el carcinoma del labio muestra unas características epidemiológicas, diagnósticas y pronosticas distintas, que hace que pueda ser derivado a diversas especialidades. Se suele presentar con mayor frecuencia en pacientes de edad avanzada [2] y con una incidencia ligeramente superior en varones de 2-3 a 1 [3], aunque la tendencia está variando progresivamente. Presenta unos factores de riesgo bien definidos, entre los que se encuentran el tabaco, la exposición solar y determinadas lesiones premalignas como la queilitis actínica, la eritroplasia de Queyrat, lesiones liquenoides crónicas, el lupus crónico o la radiodermitis [4].…”

Section: Introductionunclassified

Carcinoma de labio. Nuestra experiencia

et al. 2019

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Conflicto de intereses: Los autores declaran no tener conflictos de intereses Imágenes: Los autores declaran haber obtenido las imágenes con el permiso de los pacientes Política de derechos y autoarchivo: se permite el autoarchivo de la versión post-print (SHERPA/RoMEO) Licencia CC BY-NC-ND. Licencia Creative Commons Atribución-NoComercial-SinDerivar 4.0 Internacional Universidad de Salamanca. Su comercialización está sujeta al permiso del editor

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Section: Introductionunclassified

Carcinoma de labio. Nuestra experiencia

et al. 2019

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Section: Introductionmentioning

confidence: 99%

“…The lip represents an anatomical area of the interface between the skin and oral mucosa [ 1 ]. It is, therefore, not entirely surprising that SCC of the lip exhibits mixed features between cutaneous and oral mucosal SCC, namely regarding risk factors and biological behaviour [ 1 ]. The main risk factors for lip SCC include ultraviolet radiation exposure, low phototype, tobacco and alcohol use, and immunosuppression [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…It is, therefore, not entirely surprising that SCC of the lip exhibits mixed features between cutaneous and oral mucosal SCC, namely regarding risk factors and biological behaviour [ 1 ]. The main risk factors for lip SCC include ultraviolet radiation exposure, low phototype, tobacco and alcohol use, and immunosuppression [ 1 ]. Poor oral hygiene and dental status are also very frequent findings in patients with this neoplasm [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Neglected Under Lip Cancer

Tchernev¹,

Cardoso²,

Pidakev³

et al. 2018

Open Access Maced J Med Sci

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The lip represents an anatomical area of the interface between the skin and oral mucosa. It is, therefore, not entirely surprising that SCC of the lip exhibits mixed features between cutaneous and oral mucosal SCC, namely regarding risk factors and biological behaviour. The main risk factors for lip SCC include ultraviolet radiation exposure, low phototype, tobacco and alcohol use, and immunosuppression. Lip SCC usually presents clinically as a nodule or a tumour with a keratotic surface that commonly ulcerates. There is often a background of actinic cheilitis. The particularly exuberant presentation of our case can most probably be explained by the long evolution of a tumour before the patient reached medical attention. Patients with regional lymph node metastasis are usually offered regional lymph node dissection (usually of the neck). Radiotherapy and/or chemotherapy may be used in advanced cases, particularly in unresectable tumours, tumours with high-risk features and metastatic disease. The large size of a tumour in our case, most probably due to its long evolution, highlights the importance of timely diagnosis to avoid such extreme presentations and the consequent need for more aggressive treatment.

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“…The lips are a unique and principal feature on the face as a junctional area between keratinizing skin and oral mucosa . The lips are a unique feature in terms of histology; they have a thinner cellular layer and fewer melanocytes than typical facial skin, as well as no hair structures or sweat glands.…”

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Dermatologist‐level classification of malignant lip diseases using a deep convolutional neural network

et al. 2019

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Lip cancers are relatively rare, but early diagnosis is important for a good outcome. Unfortunately, many patients experience a delay in diagnosis. A new machine learning method, deep convolutional neural networks (DCNNs), uses algorithms which can reportedly be used to classify dermatological diseases at the same standard as board-certified dermatologists. However, this has not been verified for locations such as the lips, scalp, and genitals.A DCNN was used to classify malignant (cancerous) and benign (non-cancerous) lip disorders and its performance was evaluated. The images in this study were taken from the photo database of Seoul National University Hospital (SNUH) in South Korea. To validate the results, additional images were collected from two other affiliated hospitals. A total of 1973 lip images from SNUH were used including 853 malignant and 1120 benign diseases.The DCNN was trained with 1629 images (743 malignant, 886 benign) and its performance was evaluated using testing and external validation sets containing 344 and 281 images, respectively. For comparison, 44 participants with different levels of training were asked to classify the images.The study found that the DCNN's performance was equivalent to the dermatologists, and was superior to the nondermatologists when classifying malignancy. When they referenced the DCNN result, non-dermatologists performed significantly better.Thus, DCNNs can be used to classify lip diseases at a standard equivalent to a board-certified dermatologist and they can help unskilled physicians to discriminate between benign and malignant lip diseases. DCNNs could therefore be used to improve diagnosis and consequent patient outcomes for those with suspected lip cancers. This is a summary of the study: Dermatologist-level classification of malignant lip diseases using a deep convolutional neural network This summary relates to https://doi.

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Squamous Cell Carcinoma of the Lip—A Review of Squamous Cell Carcinogenesis of the Mucosal and Cutaneous Junction

Abstract: Lip SCC is an overlapping entity that poses many challenges to clinicians. Specialists should be aware of current staging modalities as well as imaging and treatment recommendations to optimize patient outcomes.

Cited by 31 publications

References 87 publications

Carcinoma de labio. Nuestra experiencia

Carcinoma de labio. Nuestra experiencia

Neglected Under Lip Cancer

Dermatologist‐level classification of malignant lip diseases using a deep convolutional neural network

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