Squamous cell carcinoma of the lip: is there a role for adjuvant radiotherapy in improving local control following incomplete or inadequate excision?

Babington, Scott; Veness, Michael J.; Çakır, Burcu; Gebski, Val; Morgan, Gary J.

doi:10.1046/j.1445-2197.2003.t01-1-02710.x

Cited by 63 publications

(68 citation statements)

References 24 publications

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“…14,15,17,18 Although lip cancer is known to be curable especially at the early stages of the disease, it has tremendous adverse individual and public health effects related to high medical costs and, in advanced or aggressive cases, lower survival rates and diminished quality of life due to devastating aesthetic and psychosocial sequel, functional impairment, and other serious consequences. 19 Reports regarding survival after lip cancers in the developing countries are rare.…”

Section: Resultsmentioning

confidence: 99%

The Helical Arcade

Erdmann

Bruno²,

Follmar³

et al. 2009

Journal of Craniofacial Surgery

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Survival of the ear based on a single vascular pedicle has been previously documented. The anatomic basis for this survival remains incompletely described. In the 3 clinical cases of inferior-to-superior near-total ear avulsion presented herein, the authors have observed that the ear can survive based on a narrow pedicle along the helical root. In an anatomic study to further investigate the relevant vascular anatomy, the common carotid artery system of 6 fresh human cadaver specimens was injected with latex. The superficial temporal artery and its branches located at the helical root were examined. This anatomic study showed that the upper auricular branch of the superficial temporal artery continues into the ear as the helical artery supplies an arterial arcade, which we have termed the helical arcade. This arcade seems to allow for communication between the anterior and posterior arterial systems of the ear and allows the helical artery to provide sufficient arterial supply to the entire ear.

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Section: Resultsmentioning

confidence: 99%

The Helical Arcade

Erdmann

Bruno²,

Follmar³

et al. 2009

Journal of Craniofacial Surgery

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“…Radiation treatment in these cases is important in order to prevent local failure [14]. One issue with PDR brachytherapy is that the patient must have a stable and non-kinking flexible tube implant for 6 days.…”

Section: Discussionmentioning

confidence: 99%

Clinical Investigations Long term results of PDR brachytherapy for lip cancer

Johansson¹,

Karlsson²,

Hardell³

et al. 2011

jcb

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PurposeTo evaluate the long time outcome with regard to local tumour control and side effects of a pulsed dose rate (PDR) monobrachytherapy of primary or recurrent cancer of the lip.Material and methodsBetween 1995 and 2007 we treated 43 patients with primary or recurrent clinical T1-T3N0 lip cancers. There were 22 T1 patients (51%), 16 T2 (37%) and 5 T3 cases (12%). A median dose of 60 (55-66) Gy was given, depending on the tumour volume. The PDR treatment was delivered with 0.83 Gy/pulse every second hour for 5.5-6.5 days. The patients were followed for a median of 55 (1-158) months.ResultsThe 2-, 5- and 10-year rates of actuarial local control were 97.6%, 94.5% and 94.5%, overall survival 88.0%, 58.9% and 39.1%, disease free survival 92.7%, 86.4% and 86.4% respectively. The regional control rate was 93%. One patient (2%) developed distant metastases. A dosimetrical analysis showed a mean treated volume of 14.9 (3.0-56.2) cm3. Long-term side effects were mild and the cosmetic outcome excellent, except for 1 case (2%) of soft tissue necrosis and 1 case (2%) of osteoradionecrosis.ConclusionsLocal outcome is excellent and similar to other published studies of continuous low dose rate (cLDR) brachytherapy.

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“…15,34 Indeed, several series reported improved local tumour control with the addition of radiation therapy to excision. 67,68 However, a recent systematic review of available literature showed no significant benefit of radiation therapy beyond surgery alone. 44 In practice, radiation therapy is mostly reserved for selected patients with contraindications to surgery, for palliative purposes, or as an adjunct to highrisk SCC treatment.…”

Section: Radiation Therapymentioning

confidence: 99%

Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma

et al. 2015

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Background Squamous cell carcinoma (SCC) is the second-most common form of non-melanoma skin cancer (NMSC). Objective To provide guidance to Canadian health care practitioners regarding management of SCCs. Methods Literature searches and development of graded recommendations were carried out as discussed in the accompanying introduction (chapter 1 of the NMSC guidelines). Results SCCs are sometimes confined to the epidermis, but they can also invade nearby tissues and, in some cases, metastasize to neighbouring lymph nodes or other organs. This chapter discusses the natural history, staging, prognosis, and management of SCC—a tumour type that is less common but typically more aggressive than BCC. For this reason, margin control is strongly preferred in treating SCCs. Conclusions Although approaches such as cryosurgery and radiation therapy may be considered for some patients, surgical excision—sometimes coupled with radiation—remains the cornerstone of SCC management. Patients with high-risk SCC may also be considered for referral to an appropriate multidisciplinary clinic.

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Squamous cell carcinoma of the lip: is there a role for adjuvant radiotherapy in improving local control following incomplete or inadequate excision?

Abstract: Incomplete or inadequate excision of some lip cancers results in local recurrence. If re-excision is not feasible -surgeons should consider the role of adjuvant radiotherapy in improving local control.

Cited by 63 publications

References 24 publications

The Helical Arcade

The Helical Arcade

Clinical Investigations Long term results of PDR brachytherapy for lip cancer

Non-melanoma Skin Cancer in Canada Chapter 5: Management of Squamous Cell Carcinoma

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