Squamous cell carcinoma of the oral cavity and oropharynx in patients aged 18–45 years: A case–control study to evaluate the risk factors with emphasis on stress, diet, oral hygiene, and family history

Dholam, KP; Chouksey, GC

doi:10.4103/0019-509x.197725

Cited by 16 publications

(7 citation statements)

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“…Shivappa et al [ 45 ] suggested a positive interaction between a proinflammatory diet with alcohol consumption and smoking in association with oral cancer. However, Dholam and Chouksey [ 46 ] found that a diet as a risk factor for oral cancer was not statistically significant. Moreover, this study agrees with Scully's [ 5 ] research that randomized clinical trials are needed to explore the effectiveness of dietary supplementation as chemoprevention to reduce the risk of oral cancer.…”

Section: Discussionmentioning

confidence: 99%

“…A recent study found an increased risk of oral cancer in patients who had suffered emotional stress. However, according to Dholam and Chouksey [ 46 ], emotional stress is a modern life symptom, and it may be responsible for delays in diagnosis due to work and family-related commitments, which probably generate patients' negligence toward their symptoms, but emotional stress would not be the core cause of oral cancer. Prospective studies with oral cancer patients would be necessary, excluding those who have scientifically proven risk factors, such as tobacco and alcohol consumption, and/or genetic factors, to show whether emotional stress alone could cause the disease.…”

Section: Discussionmentioning

confidence: 99%

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Oral Cancer Knowledge Assessment: Newly Graduated versus Senior Dental Clinicians

Spaulonci

Souza

Pecorari

et al. 2018

International Journal of Dentistry

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The present study assessed the level of dentists' knowledge regarding oral cancer in the city of São Paulo, Brazil. A questionnaire was used to compare the level of knowledge among newly graduated and senior clinicians. A total of 20,154 e-mails were correctly delivered to the dentists registered in the database of the Regional Dentistry Council of São Paulo, and 477 (2.36%) responses were received. This sample consisted of 84 newly graduated clinicians and 105 senior clinicians. For the statistical analysis, the chi-square test and the logistic regression analysis were performed with α = 0.05, and the results were described herein. According to their knowledge level, the results were statistically different between the groups, since 19% of the newly graduated clinicians were evaluated with knowledge grade A (excellent) in comparison to 6.7% of the senior clinicians. In spite of the results indicated that newly graduated clinicians' knowledge regarding oral cancer was 2.1 times higher, 34.5% of the professionals in this group had regular or poor knowledge on the subject, and several questions relating to clinical characteristics and risk factors indicated that there still exist some knowledge gaps, demonstrating that there is a need for further studies and information activities addressing oral cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral Cancer Knowledge Assessment: Newly Graduated versus Senior Dental Clinicians

Spaulonci

Souza

Pecorari

et al. 2018

International Journal of Dentistry

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“…Shivappa et al [ 55 ] investigated the inflammatory potential of diet and risk of oropharyngeal cancer in the Italian population, finding that a proinflammatory diet and tobacco/alcohol use correlated positively with OC. However, Dholam and Chouksey [ 56 ] found no significant correlation between diet and OC. Another study by Scully [ 57 ] concluded that further randomized clinical trials were needed to elucidate the effectiveness of dietary supplementation in minimizing OC risk and eliminating the need for chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Comparison of knowledge, awareness, and behaviors toward oral cancer among dental students and dentists: an online cross-sectional questionnaire in Türkiye

Tunç,

Toprak,

Yüce

et al. 2024

BMC Oral Health

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Objective This cross-sectional online questionnaire-based study evaluated the knowledge, awareness, and behaviors of dentists and senior dental students regarding oral cancer (OC). Materials and methods This study included 168 dentists and senior dental students who had completed all theoretical educations and clinical practices. An online survey was administered to all participants to assess their awareness of the risk factors for OC, clinical knowledge, and behaviors. The participants’ demographic characteristics and knowledge of OC were analyzed. Results Of the participants, 48.8% were female and 51.2% were male. Their mean age was 27.04 ± 5.56 years (range: 21–51). In addition, 59.5% were dentists, and 40.5% were senior dental students. The dentists’ mean time since graduation was 6.38 ± 5.64 years (range: 1–27). Routine oral mucosa examination for OC was significantly more frequent among the dentists than the senior dental students (p < 0.05). Among all participants, 33% of dentists and 51.5% of senior dental students had poor knowledge of OC-related or possibly predisposing factors. Routine evaluation of OC-related and predisposing risk factors, including human papillomavirus infection, smoking, alcohol use, trauma-related non-healing oral lesions caused by long-term incompatible prostheses, and poor oral hygiene, was significantly more frequent among the dentists than the senior dental students (p < 0.05). Conclusion Educating dental students about a more comprehensive oral examination and early diagnosis of OC would help overcome the current lack of adequate knowledge and attitudes in OC prevention and early detection. A core curriculum compatible with the global standards on OC should be provided to dental students.

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“…Poor oral hygiene is strongly associated with oral cancer, especially in association with other risk factors, such as tobacco and alcohol. A case-control study of Indian patients aged 18-45 years reported poor hygiene for 79% of the patients with oral cavity and oropharynx cancer [141]. The risk for the development of oral cancer is decreased by 26% by dental visits [142].…”

Section: Poor Oral Healthmentioning

confidence: 99%

The World of Oral Cancer and Its Risk Factors Viewed from the Aspect of MicroRNA Expression Patterns

Aghiorghiesei

Zănoagă

Nuțu

et al. 2022

Genes

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Oral cancer is one of the leading causes of death worldwide, with a reported 5-year survival rate of around 50% after treatment. Epigenetic modifications are considered to have a key role in oral carcinogenesis due to histone modifications, aberrant DNA methylation, and altered expression of miRNAs. MicroRNAs (miRNAs) are small non-coding RNAs that have a key role in cancer development by regulating signaling pathways involved in carcinogenesis. MiRNA deregulation identified in oral cancer has led to the idea of using them as potential biomarkers for early diagnosis, prognosis, and the development of novel therapeutic strategies. In recent years, a key role has been observed for risk factors in preventing and treating this malignancy. The purpose of this review is to summarize the recent knowledge about the altered mechanisms of oral cancer due to risk factors and the role of miRNAs in these mechanisms.

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Squamous cell carcinoma of the oral cavity and oropharynx in patients aged 18–45 years: A case–control study to evaluate the risk factors with emphasis on stress, diet, oral hygiene, and family history

Abstract: An increased risk of oral and pharyngeal cancer was seen in cases who had poor oral hygiene, stress, dental trauma, low BMI, family history of cancer, exposure to environmental carcinogens, and habit of placement of quid.

Cited by 16 publications

References 0 publications

Oral Cancer Knowledge Assessment: Newly Graduated versus Senior Dental Clinicians

Oral Cancer Knowledge Assessment: Newly Graduated versus Senior Dental Clinicians

Comparison of knowledge, awareness, and behaviors toward oral cancer among dental students and dentists: an online cross-sectional questionnaire in Türkiye

The World of Oral Cancer and Its Risk Factors Viewed from the Aspect of MicroRNA Expression Patterns

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