Squamous cell carcinoma of the uterine cervix metastasising to the thyroid gland: a case report

Abstract

Background Carcinoma of the uterine cervix (cervical cancer) metastasising to the thyroid gland is a rare phenomenon and only a few cases have been reported. We discuss a patient with cervical cancer presenting with thyroid and cervical lymph node metastasis, exploring the diagnostic difficulty, evaluation and treatment options. Case presentation A previously well 56-year-old female presented with multiple neck lumps for 4 months duration. Examination of the neck revealed multiple firm/hard left cervical lymph nodes with a hard thyroid nodule. There were no abdominal masses however, vaginal examination revealed a hard, unhealthy cervix. Contrast enhanced computed tomography revealed a growth in the uterine cervix with lymph node enlargement in the abdomen, chest and neck along with multiple thyroid nodules. Biopsy of the cervix and cervical lymph node and fine needle aspiration cytology of the thyroid nodules were performed, all revealing a squamous cell carcinoma. Pan-endoscopy performed to rule out any concurrent cancer of the upper aerodigestive tract was negative. The patient was started on palliative therapy, but succumbed to the disease after 6 months. Discussion and conclusion Patients who present with a thyroid nodule along with multiple cervical lymph nodes should be thoroughly assessed for possible metastatic cancers. Metastasis to the thyroid gland indicates a poor prognosis in the background of carcinoma or the uterine cervix. More awareness among the public and primary care providers is necessary regarding freely available screening programmes for early detection of cervical cancer.

Thyroid metastasis from cervical carcinoma

“…Metastasis of cervical cancer to the thyroid gland is rare, with only 14 cases having been reported, including our case ( Table 1 ) 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 . The mean age of the reported patients was 55 years (range: 36–72 years; n = 14).…”

Relapsed Carcinoma Cervix Presented with Multiple Rare Visceral Metastases

“…[ 11 ] Metastases to the thyroid gland are rare and seldom reported. [ 12 13 ] Similarly, renal metastasis is rare. They are usually incidentally diagnosed.…”