Squamous cell carcinoma of the external ear: 170 cases treated with Mohs surgery

González, Andrés; Etchichury, Dardo; Rivero, Juan Mario; Adamo, Lucia

doi:10.1016/j.bjps.2021.03.060

Cited by 6 publications

(10 citation statements)

References 37 publications

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“…Unfortunately, owing to a large loss (22%) to follow‐up, only 87 tumours had ≥ 2 years of follow‐up, and the local recurrence rate in this group increased to 5.7% (5 of 87). González et al 35 . demonstrated a local recurrence rate of 4.1% (7 of 170) at a mean interval of 11.9 months following MMS for SSC‐E.…”

Section: Specific Site Outcomesmentioning

confidence: 99%

“…Cutaneous squamous cell carcinoma of the ear Mohs et al 33 reviewed outcomes for cSCC of the ear (cSCC-E) in 1988, and reported a 5-year recurrence rate of 7.7% (43 of 558 tumours); however, this included fresh tissue and fixed tissue processing. More recently, there have been three retrospective cohort studies assessing recurrence rate following MMS for SSC-E. 31,34,35 Silapunt et al 34 found that the recurrence rate for SSC-E following MMS was 4.1% (5 of 122) with a mean follow-up of 34.6 months. Unfortunately, owing to a large loss (22%) to follow-up, only 87 tumours had ≥ 2 years of follow-up, and the local recurrence rate in this group increased to 5.7% (5 of 87).…”

Section: Specific Site Outcomesmentioning

confidence: 99%

“…reviewed outcomes for cSCC of the ear (cSCC‐E) in 1988, and reported a 5‐year recurrence rate of 7.7% (43 of 558 tumours); however, this included fresh tissue and fixed tissue processing. More recently, there have been three retrospective cohort studies assessing recurrence rate following MMS for SSC‐E 31,34,35 …”

Section: Specific Site Outcomesmentioning

confidence: 99%

See 2 more Smart Citations

A review of Mohs micrographic surgery for skin cancer. Part 3: Squamous cell carcinoma

Hunt

Earp²,

Brown³

et al. 2022

Clinical and Experimental Dermatology

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This review presents and discusses the evidence for MMS to treat cutaneous squamous cell carcinoma (cSCC). The MEDLINE, Embase and Cochrane databases were searched; 39 papers were identified for recurrence and 2 papers for costeffectiveness. We included all clinical trials and observational studies, including retrospective reports, and excluded editorials and systematic reviews or meta-analyses. We categorized the evidence under the following headings: tumour recurrence, specific site outcomes (ear, lip, scalp and periocular), cSCC with perineural invasion, and cost-effectiveness. Although there are many observational studies indicating the potential benefits of MMS in the management of certain cSCCs, no randomized controlled trials (RCT) were identified. The evidence from comparitor studies suggests that MMS has a lower recurrence rate than that of other treatments for cSCC, including standard excision. Many studies identified were single-armed, but did demonstrate a low to very low recurrence rate of cSCC following MMS. A single recent study suggests MMS for intermediate cSCC is highly cost-effective compared with wide local excision when all-in costs are considered. Since the overall quality of included studies was mixed and highly heterogeneous, further methodologically robust studies with comparator arms or comprehensive long-term registry data would be valuable. It would be ideal to employ a definitive multicentre RCT but given the evidence to date and multiple advantages to MMS, the lack of clinical equipoise makes this difficult to justify. Comparison with current modalities would likely not be ethical/achievable on a like-for-like basis given MMS provides 100% margin assessment, enables histological clearance prior to reconstruction, and minimizes the removal of uninvolved tissue.

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Section: Specific Site Outcomesmentioning

confidence: 99%

Section: Specific Site Outcomesmentioning

confidence: 99%

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A review of Mohs micrographic surgery for skin cancer. Part 3: Squamous cell carcinoma

Hunt

Earp²,

Brown³

et al. 2022

Clinical and Experimental Dermatology

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“… Proportion of males with cSCC of the total head and neck region [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ...…”

Section: Figureunclassified

“… Proportion of males with cSCC of the ear [ 21 , 23 , 29 , 31 , 32 , 35 , 38 , 39 , 43 , 45 , 58 , 65 , 75 ]. …”

Section: Figurementioning

confidence: 99%

Sex Disparity for Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Systematic Review

Tan

Seth

Fischer

et al. 2022

Cancers

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The incidence of head and neck cutaneous squamous cell carcinoma (HNcSCC) is unevenly distributed between men and women. At present, the mechanism behind this disparity remains elusive. This study conducted a systematic review and meta-analysis of proportions to investigate the disparity between sexes for patients with HNcSCC. PubMed, Scopus, EMBASE, MEDLINE, Emcare and CINAHL were searched in November 2021 and June 2022 (N > 50, English, human), and studies which examined the association between sex and HNcSCC were included. Analysis was conducted using RStudio with data and forest plots displaying males as a proportion of total patients with HNcSCC. Two independent researchers performed study selection, data extraction, data analysis and risk of bias. Eighty-two studies (1948 to 2018) comprising approximately 186,000 participants (67% male, 33% female) from 29 countries were included. Significantly more males had HNcSCC overall (71%; CI: 67–74). Males were also significantly more affected by cSCC of the ear (92%; CI: 89–94), lip (74%; CI: 66–81), and eyelid (56%; CI: 51–62). This study found HNcSCC disproportionately affected males overall and across all subtypes. Improving our understanding of sex-specific mechanisms in HNcSCC will better inform our preventive, therapeutic and prognostic practices.

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Mohs micrographic surgery challenges and new technologies to optimize care of cutaneous malignancies of the ear

Colao,

Khachemoune

2024

Arch Dermatol Res

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Squamous cell carcinoma of the external ear: 170 cases treated with Mohs surgery

Cited by 6 publications

References 37 publications

A review of Mohs micrographic surgery for skin cancer. Part 3: Squamous cell carcinoma

A review of Mohs micrographic surgery for skin cancer. Part 3: Squamous cell carcinoma

Sex Disparity for Patients with Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Systematic Review

Mohs micrographic surgery challenges and new technologies to optimize care of cutaneous malignancies of the ear

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