Squamous cell carcinoma of the prostate with concomitant adenocarcinoma in the absence of prior androgen deprivation therapy

Abstract

We present a case of squamous cell carcinoma of the prostate, unique in that it was accompanied by a spatially separate focus of high-grade adenocarcinoma. Unlike previous case reports, the patient had no history of prior prostatic adenocarcinoma and had no history of treatment with antiandrogen or radiation therapy. Prostate carcinomas with squamous differentiation, while exceedingly rare, carry a poor prognosis compared to adenocarcinomas and should be considered in male patients with obstructive urinary symptoms without increased serum prostate specific antigen.

Transformation of adenocarcinoma of prostate to squamous cell carcinoma following hormonal treatment: A case report and review of the literature

“…Squamous differentiation of prostate cancer can be encountered in pure form or associated with adenocarcinoma [11]. Most case reports of squamous transformation occurring after radiation or hormonal treatment tended to be associated with high grade adenocarcinoma, such as in our case [4], [13]. Arva et al [11] reviewed 66 cases of prostate cancer with squamous differentiation, 27 (41%) were pure SCCs and 39 (59%) were associated with adenocarcinoma.…”

“…The penile metastasis, extensive pelvic lymphadenopathy, and bony metastasis were also observed. In the third [13] and fourth [15] cases, the lesions showed extracapsular extension and bladder base invasion, respectively. These features were very similar to our patient.…”