Squamous Cell Carcinoma of the Oropharynx-<i>An Analysis of Treatment Results in 289 Consecutive Patients</i>

Johansen, Lars Vendelbo; Grau, Cai; Overgaard, Jens

doi:10.1080/02841860050215981

Cited by 38 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rise in number of patients with oropharyngeal cancer per year, here shown in our population, is in accordance with the reports by others [5, 13, 14]. Hammarstedt et al [13] found a parallell rise in HPV positive tumors with time, based on re-evaluation of the histopathology, indicating a probable cause for the sharp rise in incidence.…”

Section: Discussionsupporting

confidence: 92%

“…There are very few studies in the literature with control over the non-treated group in the patient material. In the few studies where this has been documented, we find a surprisingly large difference in the size of this group, from the Danish study [5] where only 6% of the patients did not receive curative intended treatment, to the Dutch study [4] where 22% of the patients did not receive curative intended treatment. By increasing the non-treatment group, the danger, from a clinical point of view, is that the overall survival will decrease (and the result in the treated group will theoretically go up, which is of no clinical importance).…”

Section: Discussionmentioning

confidence: 74%

“…They found a 2 years’ OS of 48.7% and a 5 years’ OS of 27.8%. Other results from studies including population-based patient material are: The Dutch multi-institutional study of tonsillar cancer by Mak-Kregar et al [4] with a 5 years’ OS of 32%, the Danish study of oropharyngeal cancers by Johansen et al [5] with a 5 years’ OS of 31%, the Finnish study on oropharyngeal cancer by Makitie et al [6] with a 3 years’ OS of 58% and a 5 years OS of 45%, and the study from Oslo by Hannisdal et al [7] of tonsillar cancer with a 5 years’ OS of 34% (Table 1). We have not found any population-based study based on modern chemo-radiation treatment.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma

Lybak

Liavaag

Olofsson

2010

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

Since 1992 we have prospectively included all head and neck cancer patients in our health region in a departmental based register. Our hospital takes care of all head and neck cancer patients in our health region consisting of approximately 1 million people. In 1997, we evaluated the results of the treatment of oropharyngeal cancer in the 1992–1997 period. On the basis of this evaluation, we changed our treatment policy for tonsillar and base of tongue carcinoma. We first changed the treatment for the lesions with worst prognosis, i.e., those with T3–T4 carcinomas, from radiotherapy only, to radical surgery and postoperative radiotherapy. We have since that time increasingly also operated the smaller oropharyngeal carcinomas. The 2 years’ overall survival and disease-specific survival for all patients diagnosed in the 1992–1997 period was 56 and 63%, respectively. The results from a similar group of patients in the 6 years’ period from 2000 to 2005, after the change in treatment, have increased to 83 and 88%. When we looked at the subgroup of patients in the 2000–2005 period treated with surgery and postoperative radiotherapy, 45 out of 69 patients (65%) presenting with an oropharyngeal cancer were fit for operation. With radical surgery and postoperative radiation therapy, the 2 years overall survival is now 91%. The 2-year disease-specific survival is 96% and the locoregional control is 98%. This is a marked improvement as compared to radiotherapy alone and definitely competitive with modern radiochemotherapy.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma

Lybak

Liavaag

Olofsson

2010

Eur Arch Otorhinolaryngol

View full text Add to dashboard Cite

show abstract

“…Agarwal et al [60] found advanced nodal disease independently prognostic for inferior LRC and DFS. N stage was found to be an independent significant factor for local, regional, LRC, DFS and OS in the study of Johansen et al [61]. Similarly, Perez et al [62] also showed that N stage was one of the most significant independent factors affecting local and/or regional tumour control and DFS.…”

Section: Discussionmentioning

confidence: 93%

“…In the study of Johansen et al [61], haemoglobin level was found to be significant only for local tumour control. Multivariate analysis in the study of Denis et al [24] revealed low haemoglobin level as the most negative factor for LRC, DFS, and OS.…”

Section: Discussionmentioning

confidence: 99%

Concurrent radiochemotherapy in locally-regionally advanced oropharyngeal squamous cell carcinoma: analysis of treatment results and prognostic factors

2012

View full text Add to dashboard Cite

BackgroundConcurrent radiochemotherapy is a recommended treatment option for patients with locally advanced squamous cell head and neck carcinomas with recent data showing the most significant absolute overall and event-free survival benefit achieved in patients with oropharyngeal tumours. The aim of this study was to analyse the results of three-dimensional conformal radiotherapy given with concomitant weekly cisplatin in patients with advanced oropharyngeal carcinoma and to identify prognostic factors influencing outcomes of this patients category.MethodsSixty-five patients with stage III or IV squamous cell carcinoma of the oropharynx who underwent concurrent radiochemotherapy between January 2005 and December 2010 were retrospectively analyzed. All patients received radiotherapy to 70 Gy/35 fractions/2 Gy per fraction/5 fractions per week. Concurrent chemotherapy consisted of weekly cisplatin (30 mg/m2) started at the first day of radiotherapy.ResultsMedian age was 57 years (range, 36 to 69 years) and 59 (90.8%) patients were male. Complete composite response was achieved in 47 patients (72.3%). Local and/or regional recurrence was the most frequent treatment failure present in 19 out of 25 patients (76.0%). At a median follow-up of 14 months (range, 5 to 72 months), 2-year local relapse-free, regional relapse-free, locoregional relapse-free, disease-free, and overall survival rates were 48.8%, 57.8%, 41.7%, 33.2% and 49.7%, respectively.On multivariate analysis the only significant factor for inferior regional relapse-free survival was the advanced N stage (p = 0.048). Higher overall stage was independent prognostic factor for poorer local relapse-free survival, locoregional relapse-free survival and disease-free survival (p = 0.022, p = 0.003 and p = 0.003, respectively). Pre-treatment haemoglobin concentration was an independent prognostic factor for local relapse-free survival, regional relapse-free survival, locoregional relapse-free survival, disease-free survival, and overall survival (p = 0.002, p = 0.021, p = 0.001, p = 0.002 and p = 0.002, respectively).ConclusionsPoor treatments results of this study suggested that introduction of intensity-modulated radiotherapy, use of induction chemotherapy followed by concurrent radiochemotherapy, accelerated radiotherapy regimens, and molecular targeted therapies could positively influence treatment outcomes. The incorporation of reversal of anaemia should be also expected to provide further improvement in locoregional control and survival in patients with advanced squamous cell carcinoma of the oropharynx.

show abstract

Analysis of Prognostic Factors in Patients With Oropharyngeal Squamous Cell Carcinoma Treated With Radiotherapy Alone or in Combination With Systemic Chemotherapy

Pedruzzi¹,

Kowalski²,

Nishimoto³

et al. 2008

Arch Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Interventions: Radiotherapy alone or with chemotherapy. Main Outcome Measures: Disease-free survival, overall survival, and treatment response. Results: Most tumors were located at the tonsil (46.8%) or base of the tongue (28.0%) and were at clinical stage III or IV (92.8%). Treatment response was associated with Zubrod scale score, weight loss, number of comorbidities, symptom-severity and Piccirillo stages, hemoglobin level, tumor site, macroscopic appearance of the tumor, and clinical stage. The 5-year overall survival rate was 17.6% and disease-free survival rate was 16.2%. The significant prognostic variables were age; Zubrod scale score; weight loss; comorbidities; Berg, Piccirillo, and symptom-severity staging; involvement of adjacent softtissue areas and bone; lymph node mobility; clinical stage; and radiotherapy doses. The multivariate analysis showed Zubrod scale score, symptom-severity staging system, Berg staging system, comorbidities, and radiotherapy dose as independent prognostic factors. Conclusion: A combination of clinical factors, such as symptoms, patients' general status, weight loss, and comorbidities, leads to a relevant stage of clinical severity that can be associated with the TNM stage as predictors of survival in oropharyngeal carcinoma.

show abstract

Squamous Cell Carcinoma of the Oropharynx-An Analysis of Treatment Results in 289 Consecutive Patients

Cited by 38 publications

References 32 publications

Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma

Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma

Concurrent radiochemotherapy in locally-regionally advanced oropharyngeal squamous cell carcinoma: analysis of treatment results and prognostic factors

Analysis of Prognostic Factors in Patients With Oropharyngeal Squamous Cell Carcinoma Treated With Radiotherapy Alone or in Combination With Systemic Chemotherapy

Contact Info

Product

Resources

About