Squamous cell carcinoma originating from cutaneous cysts: The Henry Ford Experience and review of the literature

Abstract

Given the extremely low incidence, propensity of malignant lesions to become symptomatic and efficacy of treatment, we do not recommend routine excision of all epidermal cysts. Instead, we recommend excision and pathology for all symptomatic epidermal cysts, or those that rapidly grow, or do not respond to medical therapy.

Incidental Squamous Cell Carcinoma in an Epidermal Inclusion Cyst: A Case Report and Review of the Literature

“…The incidence of SCC developing from an epidermal inclusion cyst has been estimated to range from 0.011 to 0.045% [ 1 ]. After a review of the literature, we found 41 well-documented cases of SCC arising from cutaneous epidermal inclusion cysts [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. Our findings are summarized in Table 1 and Table 2 , which shows an increase in the number of reported cases of SCC arising from epidermal inclusion cysts since 2010.…”

Squamous cell carcinoma associated with trichilemmal cyst: A rare collision tumor

“…The keratin produced by these cysts is similar to keratin derived from human hair isthmus (Kaya & Saurat, 2018). The combination of trichilemmal cysts and SCC is a very rare occasion (Veenstra, Choudhry, Krajenta, & Eide, 2016). Table 1.…”

“…During 6 months of follow-up, no relapse of the lesions was observed.Cutaneous collision tumors with SCC are uncommon. Reports described combinations of SCC with epidermal cysts(Veenstra, Choudhry, Krajenta, & Eide, 2016), melanoma(Scruggs, Rensvold, Parekh, & Butler, 2011), and apocrine carcinoma(Lorusso, Sarma, Fazekas-May, Roth, & Sarwar, 2004). A collision of SCC with trichilemmal cysts is exceptionally rare.…”

Squamous cell carcinoma arising from a nasojugal cyst

“…The lesion was excised with 0.1 mm margins and the patient underwent radiotherapy after the operation. SCCs arising within pre‐existing cysts are extremely rare and have an unknown transformation mechanism . Chronic inflammation, immunosuppression and trauma are recognised risk factors .…”

“…SCCs arising within pre‐existing cysts are extremely rare and have an unknown transformation mechanism . Chronic inflammation, immunosuppression and trauma are recognised risk factors . A history of rapid growth and a failure to medically treat a suspected infected cyst should raise suspicion for malignancy …”